Tick-borne encephalitis virus in Eastern Siberia: complete genome characteristics

Determined is the complete genome sequence of Kolarovo-2008 strain (Siberia subtype) of Tick-borne encephalitis virus (TBEV), isolated from a tick in the suburbs of the Tomsk city. Nucleotide sequence analysis testifies of the fact that the level of genetic differences within the Siberian subtype of TBEV amounts to 10 % of the nucleotide sequence and to 7 % of amino-acid sequence for certain virus genes. 3'-HTO of the genome of Siberian subtype has the highest rate of variability and the homology level ranging from 65 to 97 %. Kolarovo-2008 and Vasilchenko (isolated in Novosibirsk in 1969) strains have the highest level of genome homology. The level of dissimilarity between the two Tomsk strains is substantially higher: the total number of amino-acid substitutions in Tomsk Zausaev and Kolarovo-2008 strains equals to 124, and 3'HTO level of homology is 79 %. Identified genetic variability of the Siberian subtype of TBEV is of a great importance for further development and enhancement of tick-borne encephalitis virus diagnostics.

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THE DISTRIBUTION OF TICK-BORNE ENCEPHALITIS VIRUS GENOTYPES IN DIFFERENT TYPES OF LANDSCAPES OF EASTERN SIBERIA

Acta biomedica scientifica ◽

10.12737/article_59e8bd10164039.21079786 ◽

2017 ◽

Vol 2 (5) ◽

pp. 69-75

Author(s):

Марина Верхозина ◽

Marina Verkhozina ◽

Ирина Козлова ◽

Irina Kozlova ◽

Елена Дорощенко ◽

...

Keyword(s):

Encephalitis Virus ◽

Eastern Siberia ◽

Tick Borne Encephalitis ◽

Different Types ◽

Virus Genotypes ◽

Tick Borne Encephalitis Virus

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Reporting of New tick-borne encephalitis virus strains isolated in Eastern Siberia (Russia) in 1960-2011 and explaining them in an evolutionary context using Bayesian phylogenetic inference

Ticks and Tick-borne Diseases ◽

10.1016/j.ttbdis.2020.101496 ◽

2020 ◽

Vol 11 (5) ◽

pp. 101496 ◽

Cited By ~ 1

Author(s):

Artem N. Bondaryuk ◽

Elena A. Sidorova ◽

Renat V. Adelshin ◽

Evgeny I. Andaev ◽

Sergey V. Balakhonov

Keyword(s):

Phylogenetic Inference ◽

Encephalitis Virus ◽

Eastern Siberia ◽

Tick Borne Encephalitis ◽

Evolutionary Context ◽

Tick Borne Encephalitis Virus ◽

Bayesian Phylogenetic Inference ◽

Virus Strains

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Complete Genome Sequence of a Low-Virulence Tick-Borne Encephalitis Virus Strain

Genome Announcements ◽

10.1128/genomea.01145-16 ◽

2016 ◽

Vol 4 (5) ◽

Cited By ~ 8

Author(s):

G. Dobler ◽

M. Bestehorn ◽

M. Antwerpen ◽

A. Överby-Wernstedt

Keyword(s):

Genome Sequence ◽

Ixodes Ricinus ◽

Virus Strain ◽

Complete Genome Sequence ◽

Neurological Disease ◽

Complete Genome ◽

Encephalitis Virus ◽

Natural Focus ◽

Tick Borne Encephalitis ◽

Tick Borne Encephalitis Virus

We report here the complete genome sequence (GenBank accession no. KX268728) of tick-borne encephalitis strain HB171/11, isolated from an Ixodes ricinus tick from a natural focus where human neurological disease is rare. The strain shows unique characteristics in neuroinvasiveness and neurovirulence.

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