A dose-response study in mice of a tetravalent vaccine candidate composed of domain III-capsid proteins from dengue viruses

2017 ◽  
Vol 162 (8) ◽  
pp. 2247-2256 ◽  
Author(s):  
Iris Valdés ◽  
Ernesto Marcos ◽  
Edith Suzarte ◽  
Yusleidi Pérez ◽  
Enma Brown ◽  
...  
Keyword(s):  
Dose Response ◽  
Vaccine Candidate ◽  
Capsid Proteins ◽  
Dengue Viruses ◽  
Tetravalent Vaccine ◽  
Domain Iii ◽  
Dose Response Study

scholarly journals A novel tetravalent formulation combining the four aggregated domain III-capsid proteins from dengue viruses induces a functional immune response in mice and monkeys

2015 ◽  
Vol 27 (8) ◽  
pp. 367-379 ◽  
Author(s):  
Edith Suzarte ◽  
Lázaro Gil ◽  
Iris Valdés ◽  
Ernesto Marcos ◽  
Laura Lazo ◽  
...  
Keyword(s):  
Immune Response ◽  
Capsid Proteins ◽  
Dengue Viruses ◽  
Domain Iii

scholarly journals A dose-response study in mice of a tetravalent recombinant dengue envelope domain III protein secreted from insect cells

2020 ◽  
Author(s):  
Lijun Shao ◽  
Zheng Pang ◽  
Yu Bi ◽  
Zhenhua Li ◽  
Weiping Lin ◽  
...  
Keyword(s):  
Immune Responses ◽  
Humoral Immunity ◽  
Insect Cells ◽  
Vaccine Development ◽  
Vaccine Candidate ◽  
Potential Vaccine ◽  
Domain Iii ◽  
Dose Response Study ◽  
Development Methods ◽  
Medium Dose

Abstract Background: DENV is the most globally prevalent mosquito-transmitted virus. Induction of a broadly and potently immune response is desirable for dengue vaccine development. Methods: We constructed a secreted tetravalent EDⅢ protein from eukaryotic cells and established a MAC-ELISA method for DENV diagnosis. This work aimed to evaluate the immune responses in mice of several formulations of rEDIII containing different amounts of the tetravalent protein. Results: We demonstrated that the tetravalent protein induced humoral immunity against all four serotypes of DENV, even at the lowest dose assayed. Besides, cellular immunities against DENV-1 and DENV-2 were elicited by medium dose group. Importantly, the immune responses induced by the tetravalent formulation were functional in clearing DENV-2 in circulation of mice. Conclusions: We believe that the tetravalent formulation of secreted EDⅢ protein is a potential vaccine candidate against DENV and suggest further detailed studies of this formulation in nonhuman primates. Keywords: Dengue virus; Tetravalent; Humoral immunity; Cellular immunity; Vaccine

scholarly journals A dose-response study in mice of a tetravalent recombinant dengue envelope domain III protein secreted from insect cells

2020 ◽  
Vol 85 ◽  
pp. 104427
Author(s):  
Lijun Shao ◽  
Zheng Pang ◽  
Yu Bi ◽  
Zhenhua Li ◽  
Weiping Lin ◽  
...  
Keyword(s):  
Dose Response ◽  
Insect Cells ◽  
Domain Iii ◽  
Dose Response Study

Reduction of insulin clearance during hyperglycemic clamp. Dose-response study in normal humans

Diabetes ◽  
1988 ◽  
Vol 37 (10) ◽  
pp. 1351-1357 ◽  
Author(s):  
H. Tillil ◽  
E. T. Shapiro ◽  
A. H. Rubenstein ◽  
J. A. Galloway ◽  
K. S. Polonsky
Keyword(s):  
Dose Response ◽  
Insulin Clearance ◽  
Hyperglycemic Clamp ◽  
Normal Humans ◽  
Dose Response Study

Dose–response study of myo-inositol as an inhibitor of lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

2001 ◽  
Vol 167 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Stephen S. Hecht ◽  
Patrick M.J. Kenney ◽  
Mingyao Wang ◽  
Pramod Upadhyaya
Keyword(s):  
Dose Response ◽  
Lung Tumorigenesis ◽  
Dose Response Study

scholarly journals A randomized, fixed-dose, dose–response study of ropinirole prolonged release in advanced Parkinson's disease

2017 ◽  
Vol 7 (1) ◽  
pp. 61-72 ◽  
Author(s):  
Theresa A Zesiewicz ◽  
Stephen Chriscoe ◽  
Theresa Jimenez ◽  
James Upward ◽  
Maria Davy ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dose Response ◽  
Fixed Dose ◽  
Prolonged Release ◽  
Advanced Parkinson’S Disease ◽  
Dose Response Study
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