Experimental Treatment of Vascular Graft Infection due to Staphylococcus epidermidis by In Situ Replacement with a Rifampin-bonded Polyester Graft

ABSTRACT The efficacy of linezolid and temporin A in the prevention of prosthetic graft infection due to methicillin-resistant Staphylococcus epidermidis with intermediate resistance to glycopeptides was investigated in a subcutaneous rat pouch model. Linezolid and temporin A, alone or combined, greatly reduced the bacterial numbers compared to the effect with control drugs.

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Linezolid Alone and in Combination with Rifampicin Prevents Experimental Vascular Graft Infection Due to Methicillin-Resistant Staphylococcus aureus and Staphylococcus epidermidis

Journal of Surgical Research ◽

10.1016/j.jss.2006.10.003 ◽

2007 ◽

Vol 139 (2) ◽

pp. 170-175 ◽

Cited By ~ 17

Author(s):

Mustafa Sacar ◽

Suzan Sacar ◽

Ilknur Kaleli ◽

Gokhan Onem ◽

Huseyin Turgut ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Staphylococcus Epidermidis ◽

Vascular Graft ◽

Methicillin Resistant Staphylococcus Aureus ◽

Graft Infection ◽

Vascular Graft Infection ◽

Methicillin Resistant

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Silver-coated dacron prosthesis in the treatment of infection in arterial surgery: Case reports

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh0808410n ◽

2008 ◽

Vol 136 (7-8) ◽

pp. 410-413 ◽

Cited By ~ 2

Author(s):

Dragoslav Nenezic ◽

Predrag Matic ◽

Predrag Gajin ◽

Nenad Ilijevski ◽

Petar Popov ◽

...

Keyword(s):

Conservative Treatment ◽

Vascular Graft ◽

Graft Infection ◽

Artery Aneurysm ◽

Ptfe Graft ◽

Vascular Graft Infection ◽

Left Groin ◽

Anastomotic Pseudoaneurysm ◽

Number Of Patients

INTRODUCTION Although the incidence is low, infection of prosthetic vascular graft bears a high incidence of serious complications including 25-75% mortality rate and 40-75% limb loss. The standard treatment of vascular graft infection consists of excision of the prosthesis, wound debridement and extraanatomic revascularization. Conservative treatment might be an option in a limited number of patients. We present three cases of surgical and conservative treatment of vascular graft infection. CASE OUTLINE Case 1: A patient developed silver-coated graft infection after femorodistal arterial reconstruction performed because of critical limb ischemia. In the early postoperative period, massive skin and subcutaneous tissue necrosis developed, with the graft being exposed. After two months of persistent debridement and wound toilette, the defect was covered with a Thiersch skin graft. Case 2: PTFE graft infection in the right groin followed reconstruction of the isolated common femoral artery aneurysm. This graft was replaced with a silver-coated graft in situ. Reinfection of the proximal end of the implanted silver-coated graft occurred and the graft was exposed. After repeated debridement and wound toilette, the exposed prosthesis was covered with granulomatous tissue, and the wound healed. Case 3: A year after anastomotic pseudoaneurysm resection in the left groin, prosthesis was exposed following wound infection. This graft was substituted with a silver-coated graft in situ. The wound healed primarily. CONCLUSION These three cases demonstrate that under some circumstances vascular prosthesis infection can be successfully treated conservatively without graft removal, and also by in situ replacement using silver-coated graft.

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