Consistency of Isochromosome 7q and Trisomy 8 in Hepatosplenic γδ T-cell Lymphoma: Detection by Fluorescence in Situ Hybridization of a Splenic Touch-Preparation from a Pediatric Patient

1999 ◽  
Vol 2 (5) ◽  
pp. 478-483 ◽  
Author(s):  
Susan Coventry ◽  
Hope H. Punnett ◽  
Ewa Z. Tomczak ◽  
Danielle Casher ◽  
Maria Koehler ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
T Cell ◽  
Fluorescence In Situ Hybridization ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Γδ T Cell ◽  
Trisomy 8 ◽  
Touch Preparation ◽  
Isochromosome 7Q

Hepatosplenic gamma-delta (γδ) T-cell lymphoma is a rare but increasingly recognized lymphoid malignancy predominantly affecting young adult males. It is not well appreciated in the pediatric population. We report the third case of this aggressive lymphoma in a child as well as additional support for the consistency of the recently discovered cytogenetic abnormalities, isochromosome 7q and trisomy 8, which in this case were documented using fluorescence in situ hybridization (FISH) of a touch-preparation of the spleen.

Sinonasal T-cell Lymphoma and Wegener's Granulomatosis: Aspects in Early Differential Diagnosis

1996 ◽  
Vol 10 (4) ◽  
pp. 239-246
Author(s):  
Anders Cervin ◽  
Michael Dictor ◽  
Olof Kalm
Keyword(s):  
Differential Diagnosis ◽  
In Situ Hybridization ◽  
T Cell ◽  
Wegener’S Granulomatosis ◽  
Cell Lymphoma ◽  
Wegener's Granulomatosis ◽  
T Cell Lymphoma ◽  
Upper Airways ◽  
Gastrointestinal Complications

The clinical course of 12 patients with sinonasal T-cell lymphoma retrospectively diagnosed using in situ hybridization for Epstein-Barr virus RNA was compared with that of 10 recently treated patients with Wegener's granulomatosis (WG) in the upper airways. In particular, we studied the presenting signs and symptoms of both diseases, which commonly offer a problem in differential diagnosis at the clinical and pathological level. A bimodal age distribution was suggested in both T-cell lymphoma and WG; five patients with T-cell lymphoma developed disease prior to 40 years of age. Four of the 12 lymphoma patients had a history of “chronic rhinitis” for several years before developing mucosal ulcerations, which were initially unilateral, as opposed to the bilateral ulcerations in early sinonasal WG. Two lymphoma patients had swelling of the nasal dorsum and cheek. In contrast to the WG patients, cases of T-cell lymphoma did not exhibit associated clinical signs of arthritis, conjunctivitis, pulmonary lesions, or nephritis in the early stage of the disease. Nine of the patients with T-cell lymphoma presenting as a sinonasal lesion developed disseminated disease, variably including infiltrates in intestine, lung, CNS, and skin. Four of these patients died from gastrointestinal complications of their disease. We conclude that unilateral ulcerative or hemorrhagic polypoid mucosal lesions in the sinonasal area are suggestive of lymphoma rather than WG, and nonspecific symptoms, at least in Western patients, may be present as early as the second or third decade of life. A biopsy specimen containing T lymphocytes positive for the EBV ribonucleoprotein EBER1 on in situ hybridization offers reliable confirmation of T-cell lymphoma and is of differential diagnostic value against WG.

Nasal T-cell lymphoma associated with Epstein-Barr virus infection

1993 ◽  
Vol 107 (5) ◽  
pp. 468-470 ◽  
Author(s):  
J. Dhaliwal ◽  
D. C. Rowlands ◽  
G. Niedobitek ◽  
A. Williams ◽  
A. Das Gupta ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
T Cell ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection

A case of nasal T-cell lymphoma in a Caucasian male is reported, in which the presence of Epstein-Barr virus within tumour cells was demonstrated by in situ hybridization to the Epstein-Barr virus encoded RNAs EBER-1 and EBER-2.

scholarly journals Isochromosome 7q: the primary cytogenetic abnormality in hepatosplenic γδ T cell lymphoma

Leukemia ◽  
1997 ◽  
Vol 11 (8) ◽  
pp. 1367-1372 ◽  
Author(s):  
ELC Alonsozana ◽  
J Stamberg ◽  
D Kumar ◽  
ES Jaffe ◽  
LJ Medeiros ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cytogenetic Abnormality ◽  
Γδ T Cell ◽  
Isochromosome 7Q

Hepatosplenic γδ T-cell lymphoma with ring chromosome 7, an isochromosome 7q equivalent clonal chromosomal aberration

2006 ◽  
Vol 449 (4) ◽  
pp. 479-483 ◽  
Author(s):  
Julia Tamaska ◽  
Emma Adam ◽  
Andras Kozma ◽  
Laszlo Gopcsa ◽  
Hajnalka Andrikovics ◽  
...  
Keyword(s):  
T Cell ◽  
Chromosomal Aberration ◽  
Cell Lymphoma ◽  
Ring Chromosome ◽  
T Cell Lymphoma ◽  
Chromosome 7 ◽  
Γδ T Cell ◽  
Isochromosome 7Q ◽  
Ring Chromosome 7

A rare case of hepatosplenic γδ T-cell lymphoma expressing CD19 with ring chromosome 7 and trisomy 8

2018 ◽  
Vol 228-229 ◽  
pp. 17-20 ◽  
Author(s):  
Hemani Jain ◽  
Dhanlaxmi Shetty ◽  
Hasmukh Jain ◽  
Manju Sengar ◽  
Navin Khattry ◽  
...  
Keyword(s):  
T Cell ◽  
Rare Case ◽  
Cell Lymphoma ◽  
Ring Chromosome ◽  
T Cell Lymphoma ◽  
Chromosome 7 ◽  
Γδ T Cell ◽  
Trisomy 8 ◽  
Ring Chromosome 7
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