Peripheral blood lymphocyte apoptosis and circulating dendritic cells in patients with systemic lupus erythematosus: correlation with immunological status and disease-related symptoms

2006 ◽  
Vol 25 (2) ◽  
pp. 225-233 ◽  
Author(s):  
Ewa Robak ◽  
Anna Sysa-Jędrzejowska ◽  
Tadeusz Robak ◽  
Piotr Smolewski
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dendritic Cells ◽  
Peripheral Blood Lymphocyte ◽  
Lupus Erythematosus ◽  
Peripheral Blood ◽  
Blood Lymphocyte ◽  
Lymphocyte Apoptosis ◽  
Systemic Lupus ◽  
Immunological Status

scholarly journals Tolerogenic versus Inflammatory Activity of Peripheral Blood Monocytes and Dendritic Cells Subpopulations in Systemic Lupus Erythematosus

2012 ◽  
Vol 2012 ◽  
pp. 1-14 ◽  
Author(s):  
Tiago Carvalheiro ◽  
Ana Rodrigues ◽  
Ana Lopes ◽  
Luís Inês ◽  
Isabel Velada ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dendritic Cells ◽  
Mrna Expression ◽  
Lupus Erythematosus ◽  
Peripheral Blood ◽  
Inflammatory Activity ◽  
Inactive Disease ◽  
Blood Monocytes ◽  
Systemic Lupus ◽  
Peripheral Blood Monocytes

Abnormalities in monocytes and in peripheral blood dendritic cells (DC) subsets have been reported in systemic lupus erythematosus (SLE). We aim to clarify the tolerogenic or inflammatory role of these cells based on ICOSL or IFN-αand chemokine mRNA expression, respectively, after cell purification. The study included 18 SLE patients with active disease (ASLE), 25 with inactive disease (ISLE), and 30 healthy controls (HG). In purified plasmacytoid DC (pDC) was observed a lower ICOSL mRNA expression in ASLE and an increase in ISLE; similarly, a lower ICOSL mRNA expression in monocytes of ALSE patients was found. However, a higher ICOSL mRNA expression was observed in ASLE compared to HG in myeloid DCs. Interestingly, clinical parameters seem to be related with ICOSL mRNA expression. Regarding the inflammatory activity it was observed in purified monocytes and CD CD16+DCs an increase of CCL2, CXCL9, and CXCL10 mRNA expression in ASLE compared to HG. In myeloid DC no differences were observed regarding chemokines, and IFN-αmRNA expression. In pDC, a higher IFN-αmRNA expression was observed in ASLE. Deviations in ICOSL, chemokine, and IFN-αmRNA expression in peripheral blood monocytes and dendritic cells subpopulations in SLE appear to be related to disease activity.

scholarly journals Functional characterization of peripheral blood dendritic cells and monocytes in systemic lupus erythematosus

2011 ◽  
Vol 32 (4) ◽  
pp. 863-869 ◽  
Author(s):  
Ana Henriques ◽  
Luís Inês ◽  
Tiago Carvalheiro ◽  
Maura Couto ◽  
Ângela Andrade ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dendritic Cells ◽  
Lupus Erythematosus ◽  
Peripheral Blood ◽  
Functional Characterization ◽  
Systemic Lupus

AB0217 Dendritic cells and apoptosis in peripheral blood of patients with systemic lupus erythematosus

2013 ◽  
Vol 71 (Suppl 3) ◽  
pp. 649.18-649
Author(s):  
S.M. Rashad ◽  
E.A. Abbda ◽  
M.S. Abdelrahman ◽  
D.M. Sayed ◽  
A.S. Mohamed
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dendritic Cells ◽  
Lupus Erythematosus ◽  
Peripheral Blood ◽  
Systemic Lupus
Sign in / Sign up

Export Citation Format

Share Document