The role of interferon-gamma release assays in predicting the emergence of active tuberculosis in the setting of biological treatment: a case report and review of the literature

2014 ◽  
Vol 35 (5) ◽  
pp. 1383-1388 ◽  
Author(s):  
Rossana Scrivo ◽  
Ilaria Sauzullo ◽  
Fabio Mengoni ◽  
Valeria Riccieri ◽  
Alfonso Maria Altieri ◽  
...  
2021 ◽  
Vol 6 (1) ◽  
pp. e000663
Author(s):  
Samra Rahman ◽  
Muhammad Irfan ◽  
M A Rehman Siddiqui

Tuberculosis (TB)-associated uveitis is a common cause of infectious uveitis in the developing world. Diagnosis of TB uveitis remains a challenge. The role of interferon gamma release assays (IGRAs) is uncertain. Herein we summarise the available literature on the utility of IGRAs in the diagnosis and management of TB uveitis. We searched PubMed database from 1 August 2010 to 31 July 2020 using the following keywords alone and in combination: ‘interferon-gamma release assay’, ‘QuantiFERON’, ‘T-SPOT.TB’, ‘TB uveitis’, ‘serpiginous like choroiditis’, ‘tuberculoma’, ‘TB vasculitis’, ‘TB panuveitis’ and ‘ocular tuberculosis’. Data from 58 relevant studies were collated. The review is focused on currently marketed versions of IGRA tests: QuantiFERON-TB Gold In-Tube assay, QuantiFERON-TB Gold Plus assay (QFT-Plus) and T-SPOT.TB. We found limited evidence regarding the diagnostic utility of IGRA in patients with uveitis. No study was identified evaluating the newer QFT test—the QFT-Plus—in patients with uveitis. Similarly, there is lack of data directly comparing QFT-Plus with T-SPOT.TB specifically for the diagnosis of TB uveitis.


2014 ◽  
Vol 9 (1) ◽  
pp. 227-230 ◽  
Author(s):  
GAO-YI YANG ◽  
DAN ZHAO ◽  
WEN-ZHI ZHANG ◽  
JUN MENG ◽  
JUN LI ◽  
...  

2016 ◽  
Vol 266 ◽  
pp. e64-e67 ◽  
Author(s):  
Siobhan McLaughlin ◽  
Kirsten Kind ◽  
Lynne Thomson ◽  
Ralph Bouhaidar

Author(s):  
Jose F. Dominguez ◽  
Smit Shah ◽  
Eric Feldstein ◽  
Christina Ng ◽  
Boyi Li ◽  
...  

AbstractSinus pericranii (SP) are abnormal vascular connections between extracranial scalp venous channels and intracranial dural sinuses. This vascular abnormality rarely results in significant sequelae, but in select cases, it can be symptomatic. We describe the case of a 7-year-old girl with an SP who experienced intermittent visual, motor, and sensory symptoms not previously described in the literature. Her symptoms resolved after surgical treatment of the SP. We propose a mechanism for her symptoms and the rationale for the role of neurosurgical intervention along with a review of the literature.


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