scholarly journals Risk factors for progression of interstitial lung disease in Sjögren’s syndrome

2022 ◽  
Author(s):  
Tomoyuki Kawada
Keyword(s):  
Risk Factors ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Sjögren‘S Syndrome

A Case of Sjogren's Syndrome with Interstitial Lung Disease and Multiple Cystic Lung Disease

2001 ◽  
Vol 51 (6) ◽  
pp. 597 ◽  
Author(s):  
Dai Yong Jang ◽  
Byung Chul Shin ◽  
Ki Young Jung ◽  
Jong O Kim ◽  
Jong Tae Yang ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Cystic Lung ◽  
Cystic Lung Disease ◽  
Sjögren‘S Syndrome

scholarly journals THU0600 QUANTITATIVE INDEXES TO ASSESS THE INTERSTITIAL LUNG DISEASE, AND ITS EXTENSION, IN SJÖGREN’S SYNDROME

2019 ◽  
Author(s):  
Pablo Guisado-Vasco ◽  
Mario Silva ◽  
Miguel Angel Duarte-Millán ◽  
Gianluca Sambataro ◽  
Chiara Bertolazzi ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Quantitative Indexes ◽  
Sjögren‘S Syndrome

Sjögren's syndrome-associated interstitial lung disease: A multicenter study

2016 ◽  
Vol 12 (4) ◽  
pp. 201-205
Author(s):  
Delia Reina ◽  
Daniel Roig Vilaseca ◽  
Vicenç Torrente-Segarra ◽  
Dacia Cerdà ◽  
Ivan Castellví ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Sjögren’S Syndrome ◽  
Multicenter Study ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Sjögren‘S Syndrome

scholarly journals Quantitative assessment of interstitial lung disease in Sjögren’s syndrome

PLoS ONE ◽  
2019 ◽  
Vol 14 (11) ◽  
pp. e0224772 ◽  
Author(s):  
Pablo Guisado-Vasco ◽  
Mario Silva ◽  
Miguel Angel Duarte-Millán ◽  
Gianluca Sambataro ◽  
Chiara Bertolazzi ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Sjögren’S Syndrome ◽  
Quantitative Assessment ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Sjögren‘S Syndrome

FRI0537 INTERSTITIAL LUNG DISEASE IN PATIENTS WITH PRIMARY SJÖGREN’S SYNDROME—AN OVERVIEW OF CLINICAL CHARACTERISTICS AND TREATMENT IN A TERTIARY CENTER IN TAIWAN

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 869-869
Author(s):  
H. T. Huang
Keyword(s):  
Overall Survival ◽  
Respiratory Failure ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Treatment Groups ◽  
Sjögren‘S Syndrome

Background:Interstitial lung disease(ILD) is one of the major contributor to morbidity and mortality in primary Sjögren’s syndrome(pSS)1. However, the clinical features and prognosis were various in literatures1-3; and the optimal management were still under investigationObjectives:To characterize the clinical feature, treatment and prognosis predictor of ILD of pSS in a tertiary medical center in Taiwan.Methods:Patients who had pSS and ILD confirmed with HRCT of lung between 1999-2019 were retrospectively identified. Demographic data, autoimmune feature, complementary examinations and treatments were recorded. Change in pulmonary function tests compared with pre-rituximab or pre-cyclophosphamide levels was assessed at 6–12 months post-treatment. Secondary analyses included acute exacerbation(AE), infection, and survival between different treatment groups.Results:112 patients (mean age 68(56-80); 67% female) were analyzed with the median pSS duration 3.1 (0.8-8.0) years. Most patients presented dyspnea and cough. NSIP was the most common radiological pattern (42.9%), followed by UIP (31.3%). Rituximab was used in 11(9.8%) patients, cyclophosphamide(CYC) was used in 28(25%) patients, and combination was used in 20(17.9%) patients. The FVC level and DLCO% were stable after 6-12month post-treatment in these groups. During the median 3.4(1.3-7.7) years ILD follow up, 88 patients (78.6%) had been hospitalized because of AE or infection; with 34(30.4%) of them experiencing respiratory failure. 1-year and 5-year survival was 88.6% and 67.1%. No significant overall survival was distinguished between different treatment groups(p=0.36). Frequent AE (HR=2.17, 95% CI: 1.36-3.5) and respiratory failure (HR=29, 95% CI: 4.61-191) contributed to mortality, while UIP pattern did not (HR=1.6, 95% CI: 0.77-3.3).Figure 1.Kaplan-Meier survival plot of different treatment group: R, E+R, EConclusion:Rituximab or CYC may stabilize pulmonary function but may not benefit on overall survival. Frequent ILD AE and respiratory failure are risk factors of mortality in pSS-ILD.References:[1] McCoy SS, Sandbo N. Sjögren’s Syndrome-Associated Lung Disease.Clinical Pulmonary Medicine.2017;24(6):232-238.[2] Parambil JG, Myers JL, Lindell RM, Matteson EL, Ryu JH. Interstitial Lung Disease in Primary Sjögren Syndrome.Chest.2006;130(5):1489-1495.[3] Flament T, Bigot A, Chaigne B, Henique H, Diot E, Marchand-Adam S. Pulmonary manifestations of Sjögren’s syndrome.European Respiratory Review.2016;25:110-123.Acknowledgments:Thanks to Dr. Ting-Yuan Lan, Dr. Ko-Jen Li, Dr. Hsieh Song-Chou, Dr. I-Hsien Lee, Dr. Chen-Yen Lin, Dr. Wang Hao ChienDisclosure of Interests:None declared

Progressive fibrosis is common in patients with Sjögren’s syndrome and Interstitial lung disease

2021 ◽  
Author(s):  
Caroline Diou ◽  
Marie-Pierre Debray ◽  
Catherine Bancal ◽  
Karim Sacré ◽  
Camille Taillé ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Sjögren‘S Syndrome
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