The efficacy of lymphatic drainage and traditional massage in the prophylaxis of migraine: a randomized, controlled parallel group study

2016 ◽  
Vol 37 (10) ◽  
pp. 1627-1632 ◽  
Author(s):  
Svenja Happe ◽  
Andreas Peikert ◽  
Rudolf Siegert ◽  
Stefan Evers
Keyword(s):  
Lymphatic Drainage ◽  
Randomized Controlled ◽  
Parallel Group Study ◽  
Parallel Group

scholarly journals SP736CCR4HIGHCD4+ CELL POPULATIONS IN KIDNEY GRAFT BLOOD AFTER STEROID WITHDRAWAL: A PROSPECTIVE, RANDOMIZED, CONTROLLED, PARALLEL GROUP STUDY. PRELIMINARY RESULTS

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii390-iii390
Author(s):  
Juana Alonso-Titos ◽  
Pedro Ruiz-Esteban ◽  
Eulalia Palma ◽  
Abelardo Caballero ◽  
Veronica Lopez ◽  
...  
Keyword(s):  
Cell Populations ◽  
Kidney Graft ◽  
Steroid Withdrawal ◽  
Preliminary Results ◽  
Randomized Controlled ◽  
Parallel Group Study ◽  
Parallel Group

scholarly journals Comparative Effects of Metamizole (Dipyrone) and Naproxen on Renal Function and Prostacyclin Synthesis in Salt-Depleted Healthy Subjects - A Randomized Controlled Parallel Group Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Lea S Blaser ◽  
Urs Duthaler ◽  
Jamal Bouitbir ◽  
Anne B Leuppi-Taegtmeyer ◽  
Evangelia Liakoni ◽  
...  
Keyword(s):  
Renal Function ◽  
Urinary Excretion ◽  
Healthy Subjects ◽  
Pharmacokinetic Parameters ◽  
Short Term Treatment ◽  
Randomized Controlled ◽  
Parallel Group Study ◽  
Parallel Group ◽  
Repeated Dosing ◽  
Prostacyclin Synthesis

Aim: The objective was to investigate the effect of metamizole on renal function in healthy, salt-depleted volunteers. In addition, the pharmacokinetics of the four major metamizole metabolites were assessed and correlated with the pharmacodynamic effect using urinary excretion of the prostacyclin metabolite 6-keto-prostaglandin F1α.Methods: Fifteen healthy male volunteers were studied in an open-label randomized controlled parallel group study. Eight subjects received oral metamizole 1,000 mg three times daily and seven subjects naproxen 500 mg twice daily for 7 days. All subjects were on a low sodium diet (50 mmol sodium/day) starting 1 week prior to dosing until the end of the study. Glomerular filtration rate was measured using inulin clearance. Urinary excretion of sodium, potassium, creatinine, 6-keto-prostaglandin F1α, and pharmacokinetic parameters of naproxen and metamizole metabolites were assessed after the first and after repeated dosing.Results: In moderately sodium-depleted healthy subjects, single or multiple dose metamizole or naproxen did not significantly affect inulin and creatinine clearance or sodium excretion. Both drugs reduced renal 6-keto-prostaglandin F1α excretion after single and repeated dosing. The effect started 2 h after intake, persisted for the entire dosing period and correlated with the concentration-profile of naproxen and the active metamizole metabolite 4-methylaminoantipyrine (4-MAA). PKPD modelling indicated less potent COX-inhibition by 4-MAA (EC50 0.69 ± 0.27 µM) compared with naproxen (EC50 0.034 ± 0.033 µM).Conclusions: Short term treatment with metamizole or naproxen has no significant effect on renal function in moderately sodium depleted healthy subjects. At clinically relevant doses, 4-MAA and naproxen both inhibit COX-mediated renal prostacyclin synthesis.

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