A comparison of daptomycin alone and in combination with ceftaroline fosamil for methicillin-resistant Staphylococcus aureus bacteremia complicated by septic pulmonary emboli

2020 ◽  
Vol 39 (11) ◽  
pp. 2199-2203 ◽  
Author(s):  
Taylor Morrisette ◽  
Abdalhamid M. Lagnf ◽  
Sara Alosaimy ◽  
Michael J. Rybak
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Pulmonary Emboli ◽  
Ceftaroline Fosamil ◽  
Methicillin Resistant ◽  
Staphylococcus Aureus Bacteremia

scholarly journals Ceftaroline Plus Daptomycin for Refractory Methicillin- Resistant Staphylococcus aureus Bacteremia in a Child

2018 ◽  
Vol 23 (6) ◽  
pp. 490-493 ◽  
Author(s):  
Alan M. Hall ◽  
Sean M. McTigue
Keyword(s):  
Staphylococcus Aureus ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Clinical Improvement ◽  
Pediatric Patient ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Pulmonary Emboli ◽  
Methicillin Resistant ◽  
Staphylococcus Aureus Bacteremia

Persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia can be difficult to treat, with growing adult literature supporting the combination of ceftaroline and daptomycin for these patients. Here, we report a pediatric patient with persistent MRSA bacteremia with associated cellulitis, fasciitis, myositis, and a deep venous thrombosis causing septic pulmonary emboli. After being unable to clear the bacteremia on vancomycin and then daptomycin monotherapy, the bacteremia cleared quickly with rapid clinical improvement after the addition of ceftaroline to daptomycin. In support of this case, we also review the adult literature supporting treatment with this combination of antibiotics.

scholarly journals Ceftaroline in Combination With Trimethoprim-Sulfamethoxazole for Salvage Therapy of Methicillin-Resistant Staphylococcus aureus Bacteremia and Endocarditis

2014 ◽  
Vol 1 (2) ◽  
Author(s):  
Valeria Fabre ◽  
Marcela Ferrada ◽  
Whitney R. Buckel ◽  
Edina Avdic ◽  
Sara E. Cosgrove
Keyword(s):  
Staphylococcus Aureus ◽  
Clinical Trials ◽  
Salvage Therapy ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Treatment Success ◽  
Ceftaroline Fosamil ◽  
Methicillin Resistant ◽  
Staphylococcus Aureus Bacteremia ◽  
Report Data

Abstract No clinical trials have investigated the use of ceftaroline fosamil for salvage therapy of methicillin-resistant Staphylococcus aureus bacteremia and endocarditis. We report data on 29 patients who received ceftaroline ± another antimicrobial for this indication. Ninety percent of patients had microbiologic cure and 31% had treatment success with a median follow-up of 6 months.

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