The Role of NO Synthase in the Cardioprotective Effect of Substances of Humic Origin on the Model of Ischemia and Reperfusion of Isolated Rat Heart

2019 ◽  
Vol 166 (5) ◽  
pp. 598-601 ◽  
Author(s):  
T. V. Lasukova ◽  
M. V. Zykova ◽  
M. V. Belousov ◽  
A. S. Gorbunov ◽  
L. A. Logvinova ◽  
...  
Keyword(s):  
Rat Heart ◽  
Isolated Rat Heart ◽  
No Synthase ◽  
Cardioprotective Effect ◽  
Ischemia And Reperfusion ◽  
Isolated Rat

scholarly journals ROLE OF SDF-1α/CXCR4 AXIS TO THE CARDIOPROTECTIVE EFFECT OF ISCHEMIC POST-CONDITIONING IN ISOLATED RAT HEART

2013 ◽  
Vol 61 (10) ◽  
pp. E217
Author(s):  
Jeong-Su Kim ◽  
Ju-Hyun Park ◽  
Kook-Jin Chun ◽  
Young-Ho Jang ◽  
June-Hong Kim ◽  
...  
Keyword(s):  
Rat Heart ◽  
Isolated Rat Heart ◽  
Cardioprotective Effect ◽  
Cxcr4 Axis ◽  
Isolated Rat

THE EFFECTS OF POTASSIUM-CYANIDE ON FUNCTIONAL RECOVERY OF ISOLATED RAT HEART AFTER ISCHEMIA AND REPERFUSION: ROLE OF OXIDATIVE STRESS

2018 ◽  
Vol 25 (3) ◽  
pp. 177 ◽  
Author(s):  
Vladimir Lj Jakovljevic ◽  
Anica Petkovic ◽  
Jovana Bradic ◽  
Jovana Jeremic ◽  
Tamara Nikolic Turnic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Functional Recovery ◽  
Rat Heart ◽  
Potassium Cyanide ◽  
Isolated Rat Heart ◽  
Ischemia And Reperfusion ◽  
Isolated Rat

scholarly journals Cardioprotective Effects of 9-Hydroxyellipticine on Ischemia and Reperfusion in Isolated Rat Heart

2002 ◽  
Vol 89 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Kazuhiko Saeki ◽  
Ichiro Obi ◽  
Noriko Ogiku ◽  
Munekazu Shigekawa ◽  
Toshiaki Imagawa ◽  
...  
Keyword(s):  
Rat Heart ◽  
Isolated Rat Heart ◽  
Ischemia And Reperfusion ◽  
Cardioprotective Effects ◽  
Isolated Rat

Evaluating the possible role of mitochondrial ATP-sensitive potassium channels in the cardioprotective effects of morin in the isolated rat heart

Life Sciences ◽  
2021 ◽  
Vol 264 ◽  
pp. 118659
Author(s):  
Maryam Rameshrad ◽  
Seyedeh Farzaneh Omidkhoda ◽  
Bibi Marjan Razavi ◽  
Hossein Hosseinzadeh
Keyword(s):  
Potassium Channels ◽  
Rat Heart ◽  
Isolated Rat Heart ◽  
Cardioprotective Effects ◽  
Isolated Rat

scholarly journals Cardioprotective effect of dehydrosilybin preconditioning in isolated rat heart

2018 ◽  
Vol 1859 ◽  
pp. e87-e88
Author(s):  
Eva Gabrielova ◽  
Lenka Bartosikova ◽  
Jiri Necas ◽  
Martin Modriansky
Keyword(s):  
Rat Heart ◽  
Isolated Rat Heart ◽  
Cardioprotective Effect ◽  
Isolated Rat

Mechanisms of antifibrillatory effect of acidic reperfusion: role of perfusate bicarbonate concentration

1993 ◽  
Vol 264 (3) ◽  
pp. H783-H790 ◽  
Author(s):  
C. Ibuki ◽  
D. J. Hearse ◽  
M. Avkiran
Keyword(s):  
Heart Rate ◽  
Ventricular Fibrillation ◽  
Rat Heart ◽  
Coronary Flow ◽  
Isolated Rat Heart ◽  
Acidic Ph ◽  
Bicarbonate Concentration ◽  
Left And Right ◽  
Isolated Rat

Transient (2 min) acidic (pH 6.6) reperfusion with low [HCO3-] solution suppresses reperfusion-induced ventricular fibrillation (VF) in the isolated rat heart. Using this preparation, we tested whether the effect was mediated by the high [H+] or the low [HCO3-] of perfusate. Left and right coronary beds were independently perfused with HCO3(-)-containing (25.0 mmol/l) solution at pH 7.4. Regional ischemia was then induced by stopping flow to the left coronary bed for 10 min. Hearts were subsequently assigned to four groups (n = 12 hearts/group), and the left coronary bed was reperfused with either HCO3(-)-containing (25.0 or 4.0 mmol/l) or HCO3(-)-free (5.0 mmol/l HEPES) solution, at pH 7.4 throughout (control reperfusion) or at pH 6.6 for the first 2 min and at pH 7.4 from 2 to 5 min (acidic reperfusion). Regardless of the buffer, controls exhibited a high (92 and 100%) incidence of VF; this was reduced to 42% in both of the acidic reperfusion groups (P < 0.05). There were no intergroup differences in heart rate, coronary flow, or size of ischemic zone. Thus high [H+], rather than low [HCO3-], appears to mediate the antifibrillatory effect of transient acidic reperfusion.

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