Evaluating the possible role of mitochondrial ATP-sensitive potassium channels in the cardioprotective effects of morin in the isolated rat heart

Life Sciences ◽  
2021 ◽  
Vol 264 ◽  
pp. 118659
Author(s):  
Maryam Rameshrad ◽  
Seyedeh Farzaneh Omidkhoda ◽  
Bibi Marjan Razavi ◽  
Hossein Hosseinzadeh
Keyword(s):  
Potassium Channels ◽  
Rat Heart ◽  
Isolated Rat Heart ◽  
Cardioprotective Effects ◽  
Isolated Rat

scholarly journals ROLE OF SDF-1α/CXCR4 AXIS TO THE CARDIOPROTECTIVE EFFECT OF ISCHEMIC POST-CONDITIONING IN ISOLATED RAT HEART

2013 ◽  
Vol 61 (10) ◽  
pp. E217
Author(s):  
Jeong-Su Kim ◽  
Ju-Hyun Park ◽  
Kook-Jin Chun ◽  
Young-Ho Jang ◽  
June-Hong Kim ◽  
...  
Keyword(s):  
Rat Heart ◽  
Isolated Rat Heart ◽  
Cardioprotective Effect ◽  
Cxcr4 Axis ◽  
Isolated Rat

scholarly journals Cardioprotective Effects of 9-Hydroxyellipticine on Ischemia and Reperfusion in Isolated Rat Heart

2002 ◽  
Vol 89 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Kazuhiko Saeki ◽  
Ichiro Obi ◽  
Noriko Ogiku ◽  
Munekazu Shigekawa ◽  
Toshiaki Imagawa ◽  
...  
Keyword(s):  
Rat Heart ◽  
Isolated Rat Heart ◽  
Ischemia And Reperfusion ◽  
Cardioprotective Effects ◽  
Isolated Rat

Mechanisms of antifibrillatory effect of acidic reperfusion: role of perfusate bicarbonate concentration

1993 ◽  
Vol 264 (3) ◽  
pp. H783-H790 ◽  
Author(s):  
C. Ibuki ◽  
D. J. Hearse ◽  
M. Avkiran
Keyword(s):  
Heart Rate ◽  
Ventricular Fibrillation ◽  
Rat Heart ◽  
Coronary Flow ◽  
Isolated Rat Heart ◽  
Acidic Ph ◽  
Bicarbonate Concentration ◽  
Left And Right ◽  
Isolated Rat

Transient (2 min) acidic (pH 6.6) reperfusion with low [HCO3-] solution suppresses reperfusion-induced ventricular fibrillation (VF) in the isolated rat heart. Using this preparation, we tested whether the effect was mediated by the high [H+] or the low [HCO3-] of perfusate. Left and right coronary beds were independently perfused with HCO3(-)-containing (25.0 mmol/l) solution at pH 7.4. Regional ischemia was then induced by stopping flow to the left coronary bed for 10 min. Hearts were subsequently assigned to four groups (n = 12 hearts/group), and the left coronary bed was reperfused with either HCO3(-)-containing (25.0 or 4.0 mmol/l) or HCO3(-)-free (5.0 mmol/l HEPES) solution, at pH 7.4 throughout (control reperfusion) or at pH 6.6 for the first 2 min and at pH 7.4 from 2 to 5 min (acidic reperfusion). Regardless of the buffer, controls exhibited a high (92 and 100%) incidence of VF; this was reduced to 42% in both of the acidic reperfusion groups (P < 0.05). There were no intergroup differences in heart rate, coronary flow, or size of ischemic zone. Thus high [H+], rather than low [HCO3-], appears to mediate the antifibrillatory effect of transient acidic reperfusion.

scholarly journals Glycemia and the cardioprotective effects of insulin pre-conditioning in the isolated rat heart

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Yosuke Nakadate ◽  
Hiroaki Sato ◽  
Takeshi Oguchi ◽  
Tamaki Sato ◽  
Akiko Kawakami ◽  
...  
Keyword(s):  
Rat Heart ◽  
Isolated Rat Heart ◽  
Cardioprotective Effects ◽  
Isolated Rat

CARDIOPROTECTIVE EFFECTS OF ADENOSINE A1AND A2ARECEPTOR AGONISTS IN THE ISOLATED RAT HEART

1997 ◽  
Vol 35 (1) ◽  
pp. 57-64 ◽  
Author(s):  
GIANLUCA LOZZA ◽  
ANNAMARIA CONTI ◽  
ENNIO ONGINI ◽  
ANGELA MONOPOLI
Keyword(s):  
Rat Heart ◽  
Isolated Rat Heart ◽  
Cardioprotective Effects ◽  
Isolated Rat

scholarly journals Acute reoxygenation injury in the isolated rat heart: role of resident cardiac mast cells.

1988 ◽  
Vol 63 (6) ◽  
pp. 1044-1052 ◽  
Author(s):  
A M Keller ◽  
R M Clancy ◽  
M L Barr ◽  
C C Marboe ◽  
P J Cannon
Keyword(s):  
Mast Cells ◽  
Rat Heart ◽  
Isolated Rat Heart ◽  
Reoxygenation Injury ◽  
Isolated Rat

scholarly journals Modulation ofN-methyl-d-aspartate receptors in isolated rat heart

2017 ◽  
Vol 95 (11) ◽  
pp. 1327-1334 ◽  
Author(s):  
Ivan Srejovic ◽  
Vladimir Zivkovic ◽  
Tamara Nikolic ◽  
Nevena Jeremic ◽  
Isidora Stojic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Heart ◽  
Isolated Rat Heart ◽  
Albino Rats ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Combined Application ◽  
Wistar Albino Rats ◽  
Isolated Rat

Considering the limited data on the role of NMDA-Rs in the cardiovascular system, the aim of the present study was to examine the effects of NMDA and DL-Hcy TLHC, alone and in combination with glycine, memantine, and ifenprodil, in the isolated rat heart. The hearts of Wistar albino rats were retrogradely perfused according to the Langendorff technique at a constant perfusion pressure. The experimental protocol for all experimental groups included the stabilization period, application of estimated substance for 5 min, followed by a washout period of 10 min. Using a sensor placed in the left ventricle, we registered the following parameters of myocardial function: dp/dtmax, dp/dtmin, SLVP, DVLP, HR; CF was measured using flowmetry). We estimated the following oxidative stress biomarkers in the coronary venous effluent using spectrophotometry: TBARS, NO2−, O2−, and H2O2. NMDA alone did not induce any change in any of the observed parameters, while DL-Hcy TLHC alone, as well as a combined application of NMDA and DL-Hcy TLHC with glycine, induced a reduction of most cardiodynamic parameters. Memantine and ifenprodil induced a reduction of cardiodynamic parameters and CF, as well as some oxidative stress biomarkers.

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