Signaling mechanism of cell adhesion molecules in breast cancer metastasis: potential therapeutic targets

2011 ◽  
Vol 128 (1) ◽  
pp. 7-21 ◽  
Author(s):  
Dong-Mei Li ◽  
Yu-Mei Feng
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Cancer Metastasis ◽  
Therapeutic Targets ◽  
Breast Cancer Metastasis ◽  
Signaling Mechanism

scholarly journals miR-19b promotes breast cancer metastasis through targeting MYLIP and its related cell adhesion molecules

Oncotarget ◽  
2017 ◽  
Vol 8 (38) ◽  
pp. 64330-64343 ◽  
Author(s):  
Luqing Zhao ◽  
Yuelong Zhao ◽  
Yanong He ◽  
Yitao Mao
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Related Cell

scholarly journals The Interplay Between the Cell Adhesion Molecules CD44 and CD146 in Breast Cancer Metastasis

2014 ◽  
Vol 25 ◽  
pp. i23
Author(s):  
I. Gupta ◽  
M.E. Abdraboh ◽  
A.D. Hollenbach ◽  
S. Shanmuganathan ◽  
H. Al-Riyami ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis

Dietary Lipids, Cell Adhesion and Breast Cancer Metastasis

2002 ◽  
Author(s):  
Michael J. Toborek ◽  
Bernard Hennig ◽  
Larry W. Robertson
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Dietary Lipids

MicroRNAs as therapeutic targets in breast cancer metastasis

2021 ◽  
Author(s):  
Fahima Danesh Pouya ◽  
Yousef Rasmi ◽  
Maria Gazouli ◽  
Eleni Zografos ◽  
Mohadeseh Nemati
Keyword(s):  
Breast Cancer ◽  
Cancer Metastasis ◽  
Therapeutic Targets ◽  
Breast Cancer Metastasis

scholarly journals The Role of Immunoglobulin Superfamily Cell Adhesion Molecules in Cancer Metastasis

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Chee Wai Wong ◽  
Danielle E. Dye ◽  
Deirdre R. Coombe
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cancer Progression ◽  
Cell Adhesion Molecules ◽  
Cancer Metastasis ◽  
Clinical Problem ◽  
Metastatic Lesion ◽  
Immunoglobulin Superfamily ◽  
Metastatic Pathway ◽  
Cell Cell

Metastasis is a major clinical problem and results in a poor prognosis for most cancers. The metastatic pathway describes the process by which cancer cells give rise to a metastatic lesion in a new tissue or organ. It consists of interconnecting steps all of which must be successfully completed to result in a metastasis. Cell-cell adhesion is a key aspect of many of these steps. Adhesion molecules belonging to the immunoglobulin superfamily (Ig-SF) commonly play a central role in cell-cell adhesion, and a number of these molecules have been associated with cancer progression and a metastatic phenotype. Surprisingly, the contribution of Ig-SF members to metastasis has not received the attention afforded other cell adhesion molecules (CAMs) such as the integrins. Here we examine the steps in the metastatic pathway focusing on how the Ig-SF members, melanoma cell adhesion molecule (MCAM), L1CAM, neural CAM (NCAM), leukocyte CAM (ALCAM), intercellular CAM-1 (ICAM-1) and platelet endothelial CAM-1 (PECAM-1) could play a role. Although much remains to be understood, this review aims to raise the profile of Ig-SF members in metastasis formation and prompt further research that could lead to useful clinical outcomes.

Sign in / Sign up

Export Citation Format

Share Document