Dietary Lipids, Cell Adhesion and Breast Cancer Metastasis

2002 ◽  
Author(s):  
Michael J. Toborek ◽  
Bernard Hennig ◽  
Larry W. Robertson
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Dietary Lipids

scholarly journals The Laminin-α1 Chain-Derived Peptide, AG73, Binds to Syndecans on MDA-231 Breast Cancer Cells and Alters Filopodium Formation

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Madhavi Puchalapalli ◽  
Liang Mu ◽  
Chevaunne Edwards ◽  
Benjamin Kaplan-Singer ◽  
Pearl Eni ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Cancer Cells ◽  
Cancer Progression ◽  
Breast Cancer Cells ◽  
Cancer Metastasis ◽  
The United States ◽  
Breast Cancer Metastasis ◽  
Tumor Cell Adhesion ◽  
Tumor Environment

Breast cancer is one of the most common forms of cancer affecting women in the United States, second only to skin cancers. Although treatments have been developed to combat primary breast cancer, metastasis remains a leading cause of death. An early step of metastasis is cancer cell invasion through the basement membrane. However, this process is not yet well understood. AG73, a synthetic laminin-α1 chain peptide, plays an important role in cell adhesion and has previously been linked to migration, invasion, and metastasis. Thus, we aimed to identify the binding partner of AG73 on breast cancer cells that could mediate cancer progression. We performed adhesion assays using MCF10A, T47D, SUM1315, and MDA-231 breast cell lines and found that AG73 binds to syndecans (Sdcs) 1, 2, and 4. This interaction was inhibited when we silenced Sdcs 1 and/or 4 in MDA-231 cells, indicating the importance of these receptors in this relationship. Through actin staining, we found that silencing of Sdc 1, 2, and 4 expression in MDA-231 cells exhibits a decrease in the length and number of filopodia bound to AG73. Expression of mouse Sdcs 1, 2, and 4 in MDA-231 cells provides rescue in filopodia, and overexpression of Sdcs 1 and 2 leads to increased filopodium length and number. Our findings demonstrate an intrinsic interaction between AG73 in the tumor environment and the Sdcs on breast cancer cells in supporting tumor cell adhesion and invasion through filopodia, an important step in cancer metastasis.

Breast cancer metastasis: Putative therapeutic role of vascular cell adhesion molecule-1

2017 ◽  
Vol 40 (3) ◽  
pp. 199-208 ◽  
Author(s):  
Rohit Sharma ◽  
Rohini Sharma ◽  
Tejinder Pal Khaket ◽  
Chanchala Dutta ◽  
Bornisha Chakraborty ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Vascular Cell Adhesion ◽  
Vascular Cell ◽  
Cell Adhesion Molecule 1

scholarly journals miR-19b promotes breast cancer metastasis through targeting MYLIP and its related cell adhesion molecules

Oncotarget ◽  
2017 ◽  
Vol 8 (38) ◽  
pp. 64330-64343 ◽  
Author(s):  
Luqing Zhao ◽  
Yuelong Zhao ◽  
Yanong He ◽  
Yitao Mao
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Related Cell

scholarly journals Transcriptional suppression of AMPKα1 promotes breast cancer metastasis upon oncogene activation

2020 ◽  
Vol 117 (14) ◽  
pp. 8013-8021 ◽  
Author(s):  
Yong Yi ◽  
Deshi Chen ◽  
Juan Ao ◽  
Wenhua Zhang ◽  
Jianqiao Yi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Cancer Metastasis ◽  
Kinase Activity ◽  
Critical Role ◽  
Breast Cancer Metastasis ◽  
Transcription Control ◽  
Cell Cell

AMP-activated protein kinase (AMPK) functions as an energy sensor and is pivotal in maintaining cellular metabolic homeostasis. Numerous studies have shown that down-regulation of AMPK kinase activity or protein stability not only lead to abnormality of metabolism but also contribute to tumor development. However, whether transcription regulation of AMPK plays a critical role in cancer metastasis remains unknown. In this study, we demonstrate that AMPKα1 expression is down-regulated in advanced human breast cancer and is associated with poor clinical outcomes. Transcription of AMPKα1 is inhibited on activation of PI3K and HER2 through ΔNp63α. Ablation of AMPKα1 expression or inhibition of AMPK kinase activity leads to disruption of E-cadherin-mediated cell–cell adhesion in vitro and increased tumor metastasis in vivo. Furthermore, restoration of AMPKα1 expression significantly rescues PI3K/HER2-induced disruption of cell–cell adhesion, cell invasion, and cancer metastasis. Together, these results demonstrate that the transcription control is another layer of AMPK regulation and suggest a critical role for AMPK in regulating cell–cell adhesion and cancer metastasis.

Dietary Lipids, Cells Adhesion and Breast Cancer Metastasis

2000 ◽  
Author(s):  
Michal Toborek ◽  
Bernard Benning ◽  
Larry W. Robertson
Keyword(s):  
Breast Cancer ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Dietary Lipids

scholarly journals FER kinase promotes breast cancer metastasis by regulating α6- and β1-integrin-dependent cell adhesion and anoikis resistance

Oncogene ◽  
2013 ◽  
Vol 32 (50) ◽  
pp. 5582-5592 ◽  
Author(s):  
I A Ivanova ◽  
J F Vermeulen ◽  
C Ercan ◽  
J M Houthuijzen ◽  
F A Saig ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Β1 Integrin ◽  
Anoikis Resistance ◽  
Dependent Cell
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