Selection and evolution in the genomic landscape of copy number alterations in ductal carcinoma in situ (DCIS) and its progression to invasive carcinoma of ductal/no special type: a meta-analysis

2015 ◽  
Vol 153 (1) ◽  
pp. 101-121 ◽  
Author(s):  
Swapnil Ulhas Rane ◽  
Hasan Mirza ◽  
Anita Grigoriadis ◽  
Sarah E. Pinder
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Copy Number ◽  
Carcinoma In Situ ◽  
Invasive Carcinoma ◽  
Ductal Carcinoma ◽  
Meta Analysis ◽  
Type A ◽  
Copy Number Alterations ◽  
Genomic Landscape

Chromosomal copy number alterations (CNAs) for risk assessment of ductal carcinoma in situ (DCIS).

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 565-565
Author(s):  
Anosheh Afghahi ◽  
Erna Forgo ◽  
Aya Mitani ◽  
Manisha Desai ◽  
Sushama Varma ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Ductal Carcinoma In Situ ◽  
Copy Number ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Copy Number Alterations ◽  
Chromosomal Copy Number ◽  
Chromosomal Copy

Axillary staging in ductal carcinoma in situ with microinvasion: A meta-analysis

2021 ◽  
pp. 101557
Author(s):  
Byung Choi ◽  
Lavandan Jegatheeswaran ◽  
Maria Nakhoul ◽  
Payal Haria ◽  
Reya Srivastava ◽  
...  
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Meta Analysis ◽  
Axillary Staging

Advocating Nonsurgical Management of Patients With Small, Incidental Radial Scars at the Time of Needle Core Biopsy: A Study of 77 Cases

2015 ◽  
Vol 139 (9) ◽  
pp. 1137-1142 ◽  
Author(s):  
Cathleen Matrai ◽  
Timothy M. D'Alfonso ◽  
Lindsay Pharmer ◽  
Michele B. Drotman ◽  
Rache M. Simmons ◽  
...  
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Core Biopsy ◽  
Carcinoma In Situ ◽  
Invasive Carcinoma ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Radial Scar ◽  
Needle Core Biopsy ◽  
Ductal Hyperplasia

Context Radial scars are benign sclerosing lesions that are routinely excised when diagnosed in a needle core biopsy. Optimal management for patients with incidental and small (≤5 mm) radial scars is uncertain. Objective To assess pathologic upgrade of radial scars diagnosed in needle core biopsy samples and identify a subset of patients who could benefit from conservative management. Design Patients with a diagnosis of radial scar in a needle core biopsy who underwent excision of the biopsied area were identified. Radial scars greater than 5 mm in size and those with coexisting atypia, carcinoma, and papillary lesions were excluded. After histologic-radiographic correlation, rates of pathologic upgrade were assessed. Results Seventy-seven radial scars diagnosed in 66 patients were included. Overall, 9 of 77 (12%) showed upgrade to a high-risk lesion (6 lobular carcinoma in situ, 2 atypical ductal hyperplasia, 1 atypical lobular hyperplasia), while none (0%) showed upgrade to invasive carcinoma or ductal carcinoma in situ. One of 22 incidental radial scars (4.5%) showed upgrade on excision versus 6 of 36 (16.7%) for radial scars considered to be the radiographic target (P = .23). Older age was associated with upgrade (P < .001). Conclusions No incidental or small (≤5 mm) radial scars excised revealed invasive carcinoma or ductal carcinoma in situ on excision. Provided there is good pathologic-radiologic concordance, it appears reasonable for these patients to be managed conservatively.

Do Eligibility Criteria for Ductal Carcinoma In Situ (DCIS) Active Surveillance Trials Identify Patients at Low Risk for Upgrade to Invasive Carcinoma?

2020 ◽  
Vol 27 (11) ◽  
pp. 4459-4465 ◽  
Author(s):  
Tawakalitu O. Oseni ◽  
Barbara L. Smith ◽  
Constance D. Lehman ◽  
Charmi A. Vijapura ◽  
Niveditha Pinnamaneni ◽  
...  
Keyword(s):  
Active Surveillance ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Invasive Carcinoma ◽  
Ductal Carcinoma ◽  
Low Risk ◽  
Eligibility Criteria
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