Coronary computed tomography angiography (CCTA) in patients with suspected stable coronary artery disease (CAD): diagnostic impact and clinical consequences in the German Cardiac CT Registry depending on stress test results

2018 ◽  
Vol 35 (4) ◽  
pp. 741-748 ◽  
Author(s):  
Sebastian Barth ◽  
Mohamed Marwan ◽  
Jörg Hausleiter ◽  
Werner Moshage ◽  
Grigorios Korosoglou ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cardiac Ct ◽  
Coronary Computed Tomography Angiography ◽  
Stress Test ◽  
Stable Coronary Artery Disease ◽  
Test Results ◽  
Clinical Consequences ◽  
Artery Disease

scholarly journals NON-INVASIVE FFR DERIVED FROM STANDARD ACQUIRED CORONARY COMPUTED TOMOGRAPHY ANGIOGRAPHY (CTA) DATASETS (FFRCT) FOR THE DIAGNOSIS OF MYOCARDIAL ISCHEMIA IN PATIENTS WITH CORONARY ARTERY DISEASE (CAD): FIRST DATA OF CLINICAL USE. COMPARISON WITH INVASIVE MEASUREMENT

2018 ◽  
pp. 47-55 ◽  
Author(s):  
E. S. Pershina ◽  
V. E. Sinitsin ◽  
E. A. Mershina ◽  
I. M. Arkhipova ◽  
S. P. Semitko ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Myocardial Ischemia ◽  
Computed Tomography Angiography ◽  
Coronary Computed Tomography Angiography ◽  
Stable Coronary Artery Disease ◽  
Coronary Computed Tomography ◽  
Non Invasive ◽  
Artery Disease

Objectives: to determine the diagnostic performance of non-invasive FFR derived from standard acquired coronary computed tomography angiography (CTA) datasets (FFRCT) for the diagnosis of myocardial ischemia in patients with suspected stable coronary artery disease (CAD).Methods.Prospective study included 16 patients ((m/f – 13/3 mean age 47.8 ± 2.3 years) with CAD and coronary stenosis 40–75% lumen reduction. Coronary CTA was performed prior to ICA with invasive FFR measurement. FFRCT was calculated and interpreted in a blinded fashion by an independent Core Laboratory (HeartFlow, USA). Results were compared to invasively measured FFR, with ischemia defined as FFRCT or FFR ≤ 0.80.Results. The area under the receiver operating characteristic curve (95% CI) for FFCT was 0.90. Per-vessel sensitivity and specificity to identify myocardial ischemia were 91% and 89% for FFRCT.Conclusion.FFRCT provides high diagnostic accuracy, and discrimination for the diagnosis of hemodynamically significant CAD with invasive FFR as the reference standard. 

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