A case of lung and mediastinal and hilar lymph node metastasis in a patient with cancer of unknown primary site

Background: Mammary analogue secretory carcinoma (MASC) is a pathological entity arising in the salivary glands first described by Skalova et al. [Am J Surg Pathol 2010;34: 599–608]. Here, we report the ﬁrst case of MASC presenting as a cervical lymph node metastasis of unknown primary site together with a brief review of the literature. Case Report: We present a 74-year-old male with a painless lump in his left neck. Based on the fine-needle aspiration cytological findings, a possible malignant tumor was suspected. No evidence of a primary lesion was observed using imaging modalities including positron emission tomography/computed tomography. The patient underwent an ipsilateral modified radical neck dissection. Immunohistochemical staining showed that the neoplastic cells were positive for S100 protein and GATA3. A rearrangement of the ETV6 gene was noted during ﬂuorescence in situ hybridization, and the final histopathological diagnosis was MASC. Conclusion: We encountered a MASC presenting as a cervical lymph node metastasis of unknown primary site. No adjuvant therapy was administered, and no local recurrence or metastatic disease has been detected during a follow-up period of 9 months. This is the first case report of MASC presenting as a cervical lymph node metastasis of unknown primary site and suggests the new properties of MASC.

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Cervical lymph node metastasis from an unknown primary site

Toukeibu Gan ◽

10.5981/jjhnc.34.459 ◽

2008 ◽

Vol 34 (3) ◽

pp. 459-463

Author(s):

Hajime Ishinaga ◽

Kazuya Otsu ◽

Masayoshi Kobayashi ◽

Atsushi Yuta ◽

Kazuhiko Takeuchi

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Cervical Lymph Node ◽

Cervical Lymph Node Metastasis ◽

Primary Site ◽

Unknown Primary ◽

Unknown Primary Site ◽

Node Metastasis

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A Case of Long-term Survival with Cervical Mediastinal Lymph Node Metastasis from an Unknown Primary Site

Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) ◽

10.3919/jjsa.74.2724 ◽

2013 ◽

Vol 74 (10) ◽

pp. 2724-2728

Author(s):

Tsuyoshi OKADA ◽

Masafumi KATAOKA ◽

Toshinori OHARA ◽

Souichiro NOSE

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Mediastinal Lymph Node ◽

Primary Site ◽

Unknown Primary ◽

Mediastinal Lymph Node Metastasis ◽

Unknown Primary Site ◽

Term Survival ◽

Node Metastasis

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Colorectal Cancer Presenting as Single Pulmonary Hilar Lymph Node Metastasis

Case Reports in Surgery ◽

10.1155/2018/5474919 ◽

2018 ◽

Vol 2018 ◽

pp. 1-3

Author(s):

Ahmed M. Habib ◽

Xenophon Kassianides ◽

Samuel Chan ◽

Mahmoud Loubani ◽

Syed Qadri

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Mediastinal Lymph Node ◽

Lymph Node Involvement ◽

Pulmonary Metastasectomy ◽

Hilar Lymph Node ◽

Node Metastasis ◽

Mediastinal Metastasis ◽

Node Involvement ◽

Hilar Lymph Node Metastasis

Colorectal carcinoma is the second biggest cancer responsible for mortality. Lung metastasis is the commonest, following the liver. It is not uncommon to perform pulmonary metastasectomy and identify mediastinal metastasis. Previous studies have identified incidental lymph node involvement following routine mediastinal lymph node clearance in 20–50% of cases. However, solitary intrathoracic lymph node metastasis is exceedingly rare. Even when present, it is usually metachronous. In our case, we present an exceedingly rare case whereby the intrathoracic lymph node metastasis is solitary, not accompanying pulmonary disease and with no liver metastasis. We also review the evidence for mediastinal lymphadenectomy in the literature.

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