Synthesis and anti-hepatitis B virus activity of new pyrimidine peptide nucleic acid analogs

2012 ◽  
Vol 47 (10) ◽  
pp. 1290-1297 ◽  
Author(s):  
R. A. K. Al-Harbi ◽  
A. A.-H. Abdel-Rahman
Keyword(s):  
Hepatitis B Virus ◽  
Nucleic Acid ◽  
Hepatitis B ◽  
Peptide Nucleic Acid ◽  
Nucleic Acid Analogs ◽  
Virus Activity ◽  
B Virus

Anti-Hepatitis B Virus Activity of New Pyrimidine and Adenine Peptide Nucleic Acid Analogues

2009 ◽  
Vol 64 (1-2) ◽  
pp. 6-10 ◽  
Author(s):  
Wafaei A. Zayat ◽  
Wael A. El-Sayed ◽  
Adel A.-H. Abdel-Rahman
Keyword(s):  
Hepatitis B Virus ◽  
Nucleic Acid ◽  
Hepatitis B ◽  
Peptide Nucleic Acid ◽  
Coupling Reaction ◽  
Infectivity Assay ◽  
Virus Activity ◽  
B Virus ◽  
Nucleic Acid Analogues ◽  
Adenine Derivatives

A number of N-substituted thymine and adenine derivatives, 2a, b and 3a, b, were synthesized by the coupling reaction of 1-bromo-2,2-diethoxyethane with the corresponding base. The corresponding peptide nucleic acid (PNA) analogues, N-substituted ethylamino-3-hydroxypropanoate derivatives 5a, b and ethylamino-3-hydroxybutanoate derivatives 6a, b, were synthesized from the corresponding 2-[3,4-dihydro-5-methyl-2,4-dioxopyrimidin-1(2H)- yl]-acetaldehyde (3a) and 2-[6-amino-4H-purin-9(5H)-yl]-acetaldehyde (3b), respectively. The synthesized compounds were tested for their antiviral activity against hepatitis B virus (HBV). The plaque reduction infectivity assay was used to determine the virus count reduction as a result of the treatment with the tested compounds.

Hybridization assay of hepatitis B virus by QCM peptide nucleic acid biosensor

2008 ◽  
Vol 23 (6) ◽  
pp. 879-885 ◽  
Author(s):  
Chunyan Yao ◽  
Tangyou Zhu ◽  
Jin Tang ◽  
Rong Wu ◽  
Qinghai Chen ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Nucleic Acid ◽  
Hepatitis B ◽  
Peptide Nucleic Acid ◽  
Hybridization Assay ◽  
B Virus

Identification of rare polymerase variants of hepatitis B virus using a two-stage PCR with peptide nucleic acid clamping

2004 ◽  
Vol 72 (4) ◽  
pp. 558-565 ◽  
Author(s):  
Waka Ohishi ◽  
Hiroo Shirakawa ◽  
Yoshiiku Kawakami ◽  
Sonoko Kimura ◽  
Masaya Kamiyasu ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Nucleic Acid ◽  
Hepatitis B ◽  
Peptide Nucleic Acid ◽  
Two Stage ◽  
B Virus

Evaluation of peptide nucleic acid array for the detection of hepatitis B virus mutations associated with antiviral resistance

2011 ◽  
Vol 156 (9) ◽  
pp. 1517-1524 ◽  
Author(s):  
Young Jin Choi ◽  
Hong Soo Kim ◽  
Sae Hwan Lee ◽  
Joon Soo Park ◽  
Hae Seon Nam ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Nucleic Acid ◽  
Hepatitis B ◽  
Peptide Nucleic Acid ◽  
Antiviral Resistance ◽  
B Virus

Synthesis and Anti-Hepatitis B Virus Activity of Some 2,3-Dihydroxyprop-1-yl Unnatural Hetaryls

1999 ◽  
Vol 332 (9) ◽  
pp. 327-330 ◽  
Author(s):  
El Sayed H. El Ashry ◽  
Adel A.-H. Abdel-Rahman ◽  
Nagwa Rashed ◽  
Hanaa A. Rasheed
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Activity ◽  
B Virus
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