Application of the Glucose Hydrogen Breath Test for the Detection of Bacterial Overgrowth in Patients with Cystic Fibrosis––A Reliable Method?

2008 ◽  
Vol 54 (8) ◽  
pp. 1730-1735 ◽  
Author(s):  
Arne R. J. Schneider ◽  
Stefanie Klueber ◽  
Hans-Georg Posselt ◽  
Benjamin Funk ◽  
Lydia Murzynski ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Breath Test ◽  
Reliable Method ◽  
Bacterial Overgrowth ◽  
Hydrogen Breath Test

scholarly journals Small intestine bacterial overgrowth is frequent in cystic fibrosis: combined hydrogen and methane measurements are required for its detection.

1970 ◽  
Vol 56 (4) ◽  
Author(s):  
Aleksandra Lisowska ◽  
Jerzy Wójtowicz ◽  
Jarosław Walkowiak
Keyword(s):  
Cystic Fibrosis ◽  
Small Intestine ◽  
Breath Test ◽  
Gastrointestinal Symptoms ◽  
Bacterial Overgrowth ◽  
Additional Measurement ◽  
Hydrogen Breath Test ◽  
Small Intestine Bacterial Overgrowth ◽  
Comparative Group ◽  
Methane Measurement

Hydrogen breath test (BT) is commonly used as a diagnostic tool for the detection of small intestine bacterial overgrowth (SIBO). It was reported that colonic methane production is far more frequent in cystic fibrosis (CF) patients than in other subjects. Therefore, measuring exclusively hydrogen in the diagnostic breath test for diagnosing SIBO might be of limited value. We aimed to assess the usefulness of combined measurement of hydrogen and methane expiration for the diagnosis of SIBO in CF. The study comprised 62 CF patients aged 5 to 18 years. Three-hundred-ninety subjects assessed due to gastrointestinal symptoms for the presence of SIBO served as a comparative group. In all subjects hydrogen/methane BT using glucose was performed. A positive BT was defined as fasting hydrogen > or = 20 ppm or fasting methane > or = 10 ppm or a rise of > or = 12 ppm hydrogen or > or = 6 ppm methane over baseline during the test. In 23 (37.1%) CF patients and in 52 (13.3%) subjects from the comparative group abnormal BT results were found. In seven (11.3%) CF patients and 29 (7.4%) of the other subjects studied methane measurement allowed diagnosis of SIBO. Small intestine bacterial overgrowth is frequent in cystic fibrosis. For its detection in cystic fibrosis and other gastrointestinal patients, combined hydrogen and methane measurement instead of hydrogen breath test should be applied. Without the additional measurement of methane a significant percentage of SIBO will be missed.

scholarly journals Lactulose Hydrogen Breath Test Result Is Associated with Age and Gender

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Carolyn Newberry ◽  
Ann Tierney ◽  
Octavia Pickett-Blakely
Keyword(s):  
Breath Test ◽  
Bacterial Overgrowth ◽  
Gastrointestinal Diseases ◽  
Small Intestinal Bacterial Overgrowth ◽  
Cross Sectional Study ◽  
Hydrogen Breath Test ◽  
Cross Sectional ◽  
Lactulose Hydrogen Breath Test ◽  
Significant Difference ◽  
And Gender

Small intestinal bacterial overgrowth (SIBO) is associated with chronic gastrointestinal diseases and structural/functional abnormalities of the gastrointestinal tract. SIBO’s association with clinical characteristics is unclear. This study investigates the association between clinical factors and SIBO according to lactulose hydrogen breath test (LHBT) result.Methods. A cross-sectional study in a university-based gastroenterology practice was performed. Data was abstracted from the medical records of subjects undergoing LHBT from 6/1/2009 to 6/1/2013. Logistic regression analysis was performed to determine the association between predictor variables: age, sex, body mass index (BMI), and positive LHBT, the outcome of interest.Results. LHBT was performed in 791 subjects. Fifty-four percent had a positive LHBT. There was no statistically significant difference between the LHBT results according to age or BMI. In females, the likelihood of a positive LHBT increased with age (OR 1.02; 95% CI: 1.01–1.03). In males, the likelihood of a positive LHBT result decreased with age (OR 0.98; 95% CI: 0.97–1.00).Conclusion. There was an association between age, with respect to sex, and a positive LHBT. With increased age in females, the odds of a positive LHBT increased, while, in men, the odds of a positive LHBT decreased with age.

Sign in / Sign up

Export Citation Format

Share Document