Limbal stem cell deficiency in patients with inherited stem cell disorder of dyskeratosis congenita

2012 ◽  
Vol 32 (6) ◽  
pp. 615-622 ◽  
Author(s):  
Deniz Aslan ◽  
Rustu F. Akata ◽  
Harriet Holme ◽  
Tom Vulliamy ◽  
Inderjeet Dokal
Keyword(s):  
Stem Cell ◽  
Dyskeratosis Congenita ◽  
Limbal Stem Cell Deficiency ◽  
Limbal Stem Cell ◽  
Cell Disorder

scholarly journals Corneal Epithelial Stem Cells–Physiology, Pathophysiology and Therapeutic Options

Cells ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 2302
Author(s):  
Yue Ruan ◽  
Subao Jiang ◽  
Aytan Musayeva ◽  
Norbert Pfeiffer ◽  
Adrian Gericke
Keyword(s):  
Stem Cell ◽  
Vision Loss ◽  
Ex Vivo ◽  
Dyskeratosis Congenita ◽  
Limbal Stem Cell Deficiency ◽  
Therapeutic Options ◽  
Human Cornea ◽  
Epithelial Stem Cells ◽  
Allogenic Stem Cell Transplantation ◽  
Limbal Stem Cell

In the human cornea, regeneration of the epithelium is regulated by the stem cell reservoir of the limbus, which is the marginal region of the cornea representing the anatomical and functional border between the corneal and conjunctival epithelium. In support of this concept, extensive limbal damage, e.g., by chemical or thermal injury, inflammation, or surgery, may induce limbal stem cell deficiency (LSCD) leading to vascularization and opacification of the cornea and eventually vision loss. These acquired forms of limbal stem cell deficiency may occur uni- or bilaterally, which is important for the choice of treatment. Moreover, a variety of inherited diseases, such as congenital aniridia or dyskeratosis congenita, are characterized by LSCD typically occurring bilaterally. Several techniques of autologous and allogenic stem cell transplantation have been established. The limbus can be restored by transplantation of whole limbal grafts, small limbal biopsies or by ex vivo-expanded limbal cells. In this review, the physiology of the corneal epithelium, the pathophysiology of LSCD, and the therapeutic options will be presented.

scholarly journals Efficacy and outcome of simple limbal epithelial transplantation for limbal stem cell deficiency verified by epithelial phenotypes integrated with clinical evaluation

2021 ◽  
Author(s):  
Pinnita Prabhasawat ◽  
Chareenun Chirapapaisan ◽  
Panotsom Ngowyutagon ◽  
Pattama Ekpo ◽  
Wimolwan Tangpagasit ◽  
...  
Keyword(s):  
Stem Cell ◽  
Clinical Evaluation ◽  
Limbal Stem Cell Deficiency ◽  
Limbal Stem Cell

Photochemical tissue bonding: A potential strategy for treating limbal stem cell deficiency

2011 ◽  
Vol 43 (5) ◽  
pp. 433-442 ◽  
Author(s):  
Chuan Gu ◽  
Tao Ni ◽  
Erol E. Verter ◽  
Robert W. Redmond ◽  
Irene E. Kochevar ◽  
...  
Keyword(s):  
Stem Cell ◽  
Limbal Stem Cell Deficiency ◽  
Limbal Stem Cell ◽  
Potential Strategy

Limbal Stem Cell Deficiency and Corneal Neovascularization

2009 ◽  
Vol 24 (3) ◽  
pp. 139-148 ◽  
Author(s):  
Pauline Lim ◽  
Thomas A. Fuchsluger ◽  
Ula V. Jurkunas
Keyword(s):  
Stem Cell ◽  
Corneal Neovascularization ◽  
Limbal Stem Cell Deficiency ◽  
Limbal Stem Cell
Sign in / Sign up

Export Citation Format

Share Document