Systematic review and meta-analysis investigating autograft versus allograft cultivated limbal epithelial transplantation in limbal stem cell deficiency

2019 ◽  
Vol 39 (11) ◽  
pp. 2685-2696 ◽  
Author(s):  
Mohammad Amir Mishan ◽  
Mehdi Yaseri ◽  
Alireza Baradaran-Rafii ◽  
Mozhgan Rezaei Kanavi
Keyword(s):  
Systematic Review ◽  
Stem Cell ◽  
Meta Analysis ◽  
Limbal Stem Cell Deficiency ◽  
Limbal Stem Cell ◽  
Cultivated Limbal Epithelial Transplantation

Unilateral Partial Limbal Stem Cell Deficiency: Contralateral Versus Ipsilateral Autologous Cultivated Limbal Epithelial Transplantation

2014 ◽  
Vol 157 (3) ◽  
pp. 584-590.e2 ◽  
Author(s):  
Jayesh Vazirani ◽  
Sayan Basu ◽  
Hemal Kenia ◽  
Md Hasnat Ali ◽  
Santhosh Kacham ◽  
...  
Keyword(s):  
Stem Cell ◽  
Limbal Stem Cell Deficiency ◽  
Limbal Stem Cell ◽  
Cultivated Limbal Epithelial Transplantation

scholarly journals Midterm outcomes of penetrating keratoplasty following allogeneic cultivated limbal epithelial transplantation in patients with bilateral limbal stem cell deficiency

2021 ◽  
Vol 14 (11) ◽  
pp. 1690-1699
Author(s):  
Jun-Fa Xue ◽  
◽  
Ya-Ni Wang ◽  
Chen Chen ◽  
Ru-Fei Yang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Graft Survival ◽  
Graft Rejection ◽  
Ocular Surface ◽  
Penetrating Keratoplasty ◽  
Limbal Stem Cell Deficiency ◽  
Time Interval ◽  
Case Series Study ◽  
Limbal Stem Cell ◽  
Cultivated Limbal Epithelial Transplantation

AIM: To evaluate the midterm outcomes of penetrating keratoplasty (PK) following allogeneic cultivated limbal epithelial transplantation (CLET) for bilateral total limbal stem cell deficiency (LSCD). METHODS: Ten patients (10 eyes) with bilateral LSCD were enrolled in this prospective noncomparative case series study. Each participant underwent PK approximately 6mo after a CLET. Topical tacrolimus, topical and systemic steroids, and oral ciclosporin were administered postoperatively. Best-corrected visual acuity (BCVA), intraocular pressure (IOP), ocular surface grading scores (OSS), corneal graft epithelial rehabilitation, persistent epithelial defect (PED), immunological rejection, and graft survival rate were assessed. RESULTS: The time interval between PK and allogeneic CLET was 6.90±1.29 (6-10)mo. BCVA improved from 2.46±0.32 logMAR preoperatively to 0.77±0.55 logMAR post-PK (P<0.001). Kaplan-Meier analysis of mean graft survival revealed graft survival rates of 100% at 12 and 24mo and 80.0% at 36mo. PEDs appeared in 5 eyes at different periods post-PK, and graft rejection occurred in 4 eyes. The total OSS decreased from 12.4±4.4 before allogeneic CLET to 1.4±1.51 after PK. CONCLUSION: A sequential therapy design of PK following allogeneic CLET can maintain a stable ocular surface with improved BCVA despite the relatively high graft rejection rate.

Keratolimbal allograft for limbal stem cell deficiency after severe corneal chemical injury: a systematic review

2017 ◽  
Vol 102 (8) ◽  
pp. 1114-1121 ◽  
Author(s):  
Swapna S Shanbhag ◽  
Hajirah N Saeed ◽  
Eleftherios I Paschalis ◽  
James Chodosh
Keyword(s):  
Systematic Review ◽  
Stem Cell ◽  
Best Practice ◽  
Limbal Stem Cell Deficiency ◽  
Cochrane Library ◽  
Systematic Review Methodology ◽  
Chemical Injury ◽  
Keratolimbal Allograft ◽  
Limbal Stem Cell

PurposeTo review the published literature on outcomes of keratolimbal allograft (KLAL) for the surgical treatment of limbal stem cell deficiency (LSCD) and corneal blindness after severe corneal chemical injury.MethodsLiterature searches were conducted in the following electronic databases: MEDLINE, EMBASE, Science Citation Index, CINAHL, LILACS and the Cochrane Library. Standard systematic review methodology was applied. The main outcome measure was the proportion of eyes with best-corrected visual acuity (BCVA) ≥20/200 at last follow-up. Other measures of allograft success were also collected.ResultsWe identified six reports in which KLAL outcomes in the eyes after chemical injury could be distinguished. There were no randomised controlled studies. The outcomes of KLAL in 36 eyes of 33 patients were analysed. One study with seven eyes did not specify KLAL follow-up specific to chemical injury. Median postoperative follow-up for the other 29 eyes in 26 patients was 42 months (range 6.2–114 months). In the same 29 eyes, 69% (20/29) had BCVA ≥20/200 at the last follow-up examination. Eighty-nine per cent of all eyes (32/36) underwent penetrating keratoplasty simultaneous or subsequent to KLAL.ConclusionsThe number of studies where outcomes of KLAL in eyes with severe corneal chemical injury could be discerned was limited, and variability was observed in outcome reporting. The quality of evidence to support the use of KLAL in LSCD in severe chemical corneal burns was low. Standardisation and longer follow-up are needed to better define evidence-based best practice when contemplating surgical intervention for blindness after corneal chemical injury.PROSPERO registration numberCRD42017054733.

Central corneal basal cell density and nerve parameters in ocular surface disease and limbal stem cell deficiency: a review and meta-analysis

2020 ◽  
Vol 104 (12) ◽  
pp. 1633-1639
Author(s):  
Pradipta Bhattacharya ◽  
Katie Edwards ◽  
Damien Harkin ◽  
Katrina L Schmid
Keyword(s):  
Stem Cell ◽  
Cell Density ◽  
Basal Cell ◽  
Ocular Surface ◽  
Meta Analysis ◽  
Limbal Stem Cell Deficiency ◽  
Ocular Surface Disease ◽  
Significant Difference ◽  
Corneal Nerve ◽  
Limbal Stem Cell

ObjectiveTo conduct a review and meta-analysis for investigating the relative reduction of central corneal basal cell density (BCD) and nerve parameters in ocular surface disease (OSD) and limbal stem cell deficiency (LSCD).MethodsA systematic literature search using the terms ((1) “ocular surface disease” or “ocular surface disorder”; (2) “in vivo confocal microscopy”; (3) “limbal stem cell deficiency”; (4) “basal cell density” or “corneal basal cell density” or “central corneal basal cell density”; (5) “corneal nerves” or “corneal nerve parameters” or “central corneal nerve parameters”) was performed. The results are presented as weighted mean difference (WMD) with corresponding 95% CI.Results16 studies that reported the central corneal BCD and 21 studies that reported the central corneal nerve parameters in OSD (including LSCD) were included. A significant reduction in central corneal BCD was observed in patients with various OSDs (WMD=−9.50, 95% CI −14.04 to −4.97, p<0.01) as well as in patients with LSCD (WMD=−22.14, 95% CI −37.91 to −6.37, p<0.01) compared with healthy controls, however, no significant difference in BCD was observed between the two groups (WMD=−11.61, 95% CI −15.96 to −7.26, p=0.13). There was no conclusive difference in various central corneal nerve parameters between OSDs and LSCD.ConclusionCentral corneal BCD and nerve parameters are reduced in LSCD, there is a similar reduction in other OSDs.

Clinical outcomes of xeno-free allogeneic cultivated limbal epithelial transplantation for bilateral limbal stem cell deficiency

2012 ◽  
Vol 96 (12) ◽  
pp. 1504-1509 ◽  
Author(s):  
Sayan Basu ◽  
Mark M Fernandez ◽  
Sujata Das ◽  
Subhash Gaddipati ◽  
Geeta K Vemuganti ◽  
...  
Keyword(s):  
Stem Cell ◽  
Clinical Outcomes ◽  
Limbal Stem Cell Deficiency ◽  
Limbal Stem Cell ◽  
Cultivated Limbal Epithelial Transplantation

scholarly journals Evaluating the clinical translational relevance of animal models for limbal stem cell deficiency: A systematic review

2021 ◽  
Author(s):  
Naomi C. Delic ◽  
Jessie R. Cai ◽  
Stephanie L. Watson ◽  
Laura E. Downie ◽  
Nick Di Girolamo
Keyword(s):  
Systematic Review ◽  
Stem Cell ◽  
Animal Models ◽  
Limbal Stem Cell Deficiency ◽  
Limbal Stem Cell

Boston keratoprosthesis type 1 for limbal stem cell deficiency after severe chemical corneal injury: A systematic review

2018 ◽  
Vol 16 (3) ◽  
pp. 272-281 ◽  
Author(s):  
Swapna S. Shanbhag ◽  
Hajirah N. Saeed ◽  
Eleftherios I. Paschalis ◽  
James Chodosh
Keyword(s):  
Systematic Review ◽  
Stem Cell ◽  
Limbal Stem Cell Deficiency ◽  
Boston Keratoprosthesis ◽  
Corneal Injury ◽  
Limbal Stem Cell
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