Long-term effects of trabeculectomy in primary open-angle glaucoma on segmented macular ganglion cell complex alterations

2021 ◽  
Author(s):  
Atılım Armağan Demirtaş ◽  
Mine Karahan ◽  
Seyfettin Erdem ◽  
Adar Aslan Kaya ◽  
Uğur Keklikçi
Keyword(s):  
Ganglion Cell ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Cell Complex ◽  
Ganglion Cell Complex ◽  
Open Angle ◽  
Long Term Effects

scholarly journals Macular vessel density versus ganglion cell complex thickness for detection of early primary open-angle glaucoma

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yiwei Wang ◽  
Chen Xin ◽  
Meng Li ◽  
David L. Swain ◽  
Kai Cao ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Case Series ◽  
Cell Complex ◽  
Vessel Density ◽  
Ganglion Cell Complex ◽  
Open Angle ◽  
Percent Reduction ◽  
Healthy Eyes

Abstract Background To evaluate the macular vessel density (VD) and ganglion cell complex (GCC) thickness in pre-perimetric (PPG) and early perimetric primary open-angle glaucoma (PG) eyes, and to compare the diagnostic ability of the two measurements to discriminate PPG and early PG eyes from healthy eyes. Methods Seventy-nine eyes in 72 subjects (31 normal, 26 PPG, and 22 early PG eyes) were included in the consecutive case series. Macular VD and GCC thickness were acquired simultaneously using the 6 × 6 mm2 high-density AngioRetina scanning mode. Diagnostic abilities were assessed using the area under the receiver operating characteristic curve (AUROC). Results Compared to healthy eyes, whole image VD (wiVD) and GCC thickness were significantly lower in PPG and early PG eyes (all P < 0.025). The percent reduction of wiVD was lower than that of GCC thickness in early PG eyes (P < 0.05), while they were similar in PPG eyes (P > 0.05). Regionally, greater VD attenuation and GCC thinning were identified in the perifovea than in the parafovea in both groups (all P < 0.05). Moreover, the percent reduction of VD was less than that of GCC thickness in the perifoveal region in PPG eyes (P < 0.05). The AUROCs for wiVD and GCC thickness were 0.824 and 0.881, respectively, in PPG eyes (P > 0.05), and 0.918 and 0.977, respectively, in early PG eyes (P > 0.05). Conclusions Macular VD and GCC thickness significantly decreased in PPG and early PG eyes. The perifoveal region appeared to be more vulnerable to macular VD attenuation and GCC thinning in early glaucoma. Our results showed that macular VD measurements may be helpful for detecting and understanding early glaucomatous damage.

Diagnostic accuracy of ganglion cell complex substructures in different stages of primary open-angle glaucoma

2017 ◽  
Vol 52 (4) ◽  
pp. 355-360 ◽  
Author(s):  
Amal M. Elbendary ◽  
Mohamed Hafez Abd El-latef ◽  
Hisham I. Elsorogy ◽  
Kamal M. Enaam
Keyword(s):  
Diagnostic Accuracy ◽  
Ganglion Cell ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Cell Complex ◽  
Ganglion Cell Complex ◽  
Open Angle

scholarly journals Ganglion Cell Complex Thickness and Macular Vessel Density Loss in Primary Open-Angle Glaucoma

Ophthalmology ◽  
2020 ◽  
Vol 127 (8) ◽  
pp. 1043-1052 ◽  
Author(s):  
Huiyuan Hou ◽  
Sasan Moghimi ◽  
James A. Proudfoot ◽  
Elham Ghahari ◽  
Rafaella C. Penteado ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Cell Complex ◽  
Vessel Density ◽  
Ganglion Cell Complex ◽  
Open Angle

Relationship of macular ganglion cell complex thickness to choroidal microvasculature drop-out in primary open-angle glaucoma

2022 ◽  
pp. bjophthalmol-2021-320621
Author(s):  
Eleonora Micheletti ◽  
Sasan Moghimi ◽  
Nevin El-Nimri ◽  
Takashi Nishida ◽  
Min Hee Suh ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Cell Complex ◽  
Drop Out ◽  
Mean Deviation ◽  
Ganglion Cell Complex ◽  
Open Angle ◽  
Mean Differences ◽  
Relationship Of

Background/aimsTo investigate the rate of ganglion cell complex (GCC) thinning in primary open-angle glaucoma (POAG) patients with and without deep-layer microvasculature drop-out (MvD).MethodsPOAG patients who had at least 1.5 years of follow-up and a minimum of three visits were included from the Diagnostic Innovations in Glaucoma Study. MvD was detected at baseline by optical coherence tomography angiography (OCT-A). Area and angular circumference of MvD were evaluated on en face choroidal vessel density images and horizontal B-scans. Rates of global and hemisphere GCC thinning were compared in MvD and non-MvD eyes using linear mixed-effects models.ResultsThirty-six eyes with MvD and 37 eyes without MvD of 63 patients were followed for a mean of 3.3 years. In 30 out of 36 eyes, MvD was localised in the inferotemporal region. While mean baseline visual field mean deviation was similar between the two groups (p=0.128), global GCC thinning was significantly faster in eyes with MvD than in those without MvD (mean differences: −0.50 (95% CI −0.83 to –0.17) µm/year; p=0.003)). Presence of MvD, area and angular circumference of MvD were independently associated with a faster rate of thinning (p=0.002, p=0.031 and p=0.013, respectively).ConclusionIn POAG eyes, GCC thinning is faster in eyes with MvD. Detection of MvD in OCT-A images can assist clinicians to identify patients who are at higher risk for central macula thinning and glaucomatous progression and may require more intensive management.

scholarly journals The Effects of Trabeculectomy on Pseudoexfoliation Glaucoma and Primary Open-Angle Glaucoma

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Fan Li ◽  
Guangxian Tang ◽  
Hengli Zhang ◽  
Xiaowei Yan ◽  
Lihua Ma ◽  
...  
Keyword(s):  
Medical Treatment ◽  
Success Rate ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Success Rates ◽  
Pseudoexfoliation Glaucoma ◽  
Long Term Effects ◽  
Surgical Success

Purpose. To compare long-term effects of trabeculectomy on pseudoexfoliation glaucoma (PXG) and primary open-angle glaucoma (POAG). Methods. This retrospective case-control study included 53 eyes of PXG and 76 eyes of POAG. Intraocular pressure (IOP), number of antiglaucoma medications used, surgical success rate, and occurrence of complications were observed and statistically analyzed in both groups at 3 and 6 months and at 1, 3, and 5 years after trabeculectomy. Surgical success was defined according to the following 3 criteria: (1) IOP ≤ 21 mmHg; (2) IOP ≤ 18 mmHg; (3) IOP ≤ 15 mmHg. Complete success is defined as patients met these criteria without medical treatment, and qualified success is defined as patients met these criteria with medical treatment (≤3 medications). Cumulative probabilities of success were compared using the Kaplan–Meier survival analysis. Results. For the 3 criteria, there were no statistically significant differences in complete and qualified success rates between the two groups at 3 and 6 months after trabeculectomy (P>0.05). For criterion A, complete success rates in PXG at 3 and 5 years after surgery were lower than those in POAG; for criterion B, complete and qualified success rates in PXG at 3 and 5 years after surgery were lower than those in POAG; for criterion C, complete and qualified success rates in PXG at 1, 3, and 5 years after surgery were lower than those in POAG, the differences were statistically significant (P<0.05). Conclusions. The short-term success rates of both types of glaucoma were similar; however, the long-term success rate of PXG was significantly lower, and it was difficult to achieve long-term control of IOP at a low target level.

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