Improving the Diagnosis of Autism Spectrum Disorder in Fragile X Syndrome by Adapting the Social Communication Questionnaire and the Social Responsiveness Scale-2

2019 ◽  
Vol 50 (9) ◽  
pp. 3276-3295 ◽  
Author(s):  
Sharon A. Kidd ◽  
Elizabeth Berry-Kravis ◽  
Tse Hwei Choo ◽  
Chen Chen ◽  
Amy Esler ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Fragile X Syndrome ◽  
Social Communication ◽  
Fragile X ◽  
Autism Spectrum ◽  
Social Responsiveness Scale ◽  
Spectrum Disorder ◽  
Social Responsiveness ◽  
Social Communication Questionnaire ◽  
The Social

The utility of parent-report screening tools in differentiating autism versus attention-deficit/hyperactivity disorder in school-age children

Autism ◽  
2021 ◽  
pp. 136236132110300
Author(s):  
Sara Guttentag ◽  
Somer Bishop ◽  
Rebecca Doggett ◽  
Rebecca Shalev ◽  
Megan Kaplan ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Social Communication ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Social Responsiveness ◽  
School Age ◽  
Social Communication Questionnaire ◽  
Hyperactivity Disorder ◽  
The Social

Symptoms of autism spectrum disorder and attention-deficit/hyperactivity disorder often co-occur, challenging timely, and accurate diagnosis. We assessed the performance of three parent-report measures in discriminating autism spectrum disorder from attention-deficit/hyperactivity disorder without autism spectrum disorder (ADHDw/oASD) in school-age verbally fluent children. We examined the Autism Symptom Interview – School-Age and two widely used parent questionnaires: Social Responsiveness Scale – 2nd Edition and Social Communication Questionnaire – Lifetime. Receiver operating characteristic curves assessed each instrument’s performance against the best-estimate clinician Diagnostic and Statistical Manual of Mental Disorders, 5th Edition diagnosis of autism spectrum disorder or of ADHDw/oASD ( n = 74, n = 102, respectively; 6–11 years). These yielded moderate accuracies: area under the curve = 0.85, 0.79, and 0.78 for Social Communication Questionnaire – Lifetime, Autism Symptom Interview, and Social Responsiveness Scale – 2nd Edition, respectively. Area under the curve pairwise comparisons reached our statistical significance ( p < 0.01) for the Social Communication Questionnaire – Lifetime versus the Social Responsiveness Scale – 2nd Edition. Within instruments, sensitivity and specificity varied across autism spectrum disorder cutoffs. Along with the between-instrument variability, this indicates that clinicians and researchers have valid options, depending on the settings and their goals. Comparing children correctly and incorrectly classified as autism spectrum disorder showed no differences in demographics, intellectual abilities, or in any specific clinical profile(s), except for the degree of parent concerns across autism spectrum disorder and comorbid psychopathology-related symptoms. Together, results suggest that complementing parent screeners with multiple sources may be needed to best differentiate school-age verbally fluent children with autism spectrum disorder versus ADHDw/oASD. Lay abstract We tested the ability of a short, recently developed parent interview and two widely used parent-report questionnaires to discriminate school-age verbal children with autism spectrum disorder from those with attention-deficit/hyperactivity disorder without autism spectrum disorder (ADHDw/oASD). These measures included the Autism Symptom Interview – School-Age, the Social Responsiveness Scale – 2nd Edition, and the Social Communication Questionnaire – Lifetime. The classification accuracy of all three parent screeners fell in the moderate range. Accuracy varied by instrument, and the Social Communication Questionnaire – Lifetime questionniare showed the highest accuracy. Children with autism spectrum disorder who were incorrectly classified by all parent screeners did not differ from those correctly classified in regard to demographics, intellectual abilities, nor in any specific clinical area beyond general parent concerns. These findings showed that there are valid screening options for assessing school-age verbal children with autism spectrum disorder versus ADHDw/oASD. They also underscore the need to assess multiple sources of information for increased accuracy.

How useful is the Social Communication Questionnaire in toddlers at risk of autism spectrum disorder?

2010 ◽  
Vol 51 (11) ◽  
pp. 1260-1268 ◽  
Author(s):  
Iris Oosterling ◽  
Nanda Rommelse ◽  
Maretha de Jonge ◽  
Rutger Jan van der Gaag ◽  
Sophie Swinkels ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
At Risk ◽  
Social Communication ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Social Communication Questionnaire ◽  
The Social

Validity of the Social Communication Questionnaire in Adults With Intellectual Disabilities and Suspected Autism Spectrum Disorder

2015 ◽  
Vol 120 (3) ◽  
pp. 203-214 ◽  
Author(s):  
Tanja Sappok ◽  
Albert Diefenbacher ◽  
Isabell Gaul ◽  
Sven Bölte
Keyword(s):  
Autism Spectrum Disorder ◽  
Intellectual Disabilities ◽  
Social Communication ◽  
Pervasive Developmental Disorders ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Current Version ◽  
Social Communication Questionnaire ◽  
The Social ◽  
Adults With Intellectual Disabilities

Abstract This study examined the validity of the Social Communication Questionnaire (SCQ) to identify autism spectrum disorder (ASD) in 151 adults with intellectual disabilities (ID) in Germany. Sensitivities and specificities for ASD were 98/47% for the SCQ-current version and 92/22% for the SCQ-lifetime version. Sensitivities and specificities were increased to 89/66% and 78/48% by adjusting the recommended cut-points. The SCQ-current score correlated with the Scale for Pervasive Developmental Disorders in Mentally Retarded Persons and the Autism Diagnostic Observation Schedule, whereas the SCQ-lifetime score correlated with the Autism Diagnostic Interview-Revised. Our findings support the use of the SCQ-current version for ASD screening in adults with ID, although the SCQ-lifetime version should be used with caution in this population.

Differentiating Autism Spectrum Disorder From ADHD Using the Social Communication Questionnaire

2018 ◽  
Vol 23 (8) ◽  
pp. 828-837 ◽  
Author(s):  
Anissa Mouti ◽  
Rachel Dryer ◽  
Michael Kohn
Keyword(s):  
Autism Spectrum Disorder ◽  
Social Communication ◽  
Area Under The Curve ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Typically Developing ◽  
Optimal Cutoff ◽  
Social Communication Questionnaire ◽  
The Social ◽  
Dual Diagnoses

Objective: This study examined the ability of the Social Communication Questionnaire (SCQ) to differentiate between autism spectrum disorder (ASD), ADHD, and typically developing (TD) children. Method: Children ( Mage = 11.27 years, SDage = 3.28) identified with ASD Severity Levels “1” and/or “2” ( n = 28), ADHD ( n = 44), dual diagnoses of ADHD and ASD ( n = 29), and TD ( n = 61) were assessed using the SCQ. Results: The SCQ differentiated between ASD and non-ASD groups. Children with ASD had higher total and domain scores on the SCQ than ADHD and TD children. The optimal cutoff total score of 13 was identified for differentiating between ASD and ADHD groups (area under the curve [AUC] = .96). Twenty eight of the 39 items were identified as significant in differentiating between ASD and ADHD. Conclusion: The SCQ continues to be a well-validated screening tool for ASD and is suitable for determining whether further ASD assessment is warranted in children with ADHD symptoms.

scholarly journals Validation of the Arabic version of the Social Communication Questionnaire

Autism ◽  
2019 ◽  
Vol 23 (7) ◽  
pp. 1655-1662 ◽  
Author(s):  
Mohammed Aldosari ◽  
Eric Fombonne ◽  
Hesham Aldhalaan ◽  
Mohammed Ouda ◽  
Saba Elhag ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Confidence Interval ◽  
Social Communication ◽  
Area Under The Curve ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Typically Developing ◽  
Typically Developing Children ◽  
Social Communication Questionnaire ◽  
The Social

Validated screening and diagnostic tools for autism spectrum disorder for use in Arabic-speaking individuals are scarce. This study validated the Arabic version of the Social Communication Questionnaire. The total study sample included 206 children with autism spectrum disorder and 206 typically developing children (73.8% male; mean age: 8.5 (standard deviation = 2.6) years). The mean Social Communication Questionnaire total score was significantly higher in autism spectrum disorder children than in typically developing children ( p < 0.0001). Scores on the three Social Communication Questionnaire subscales also differed significantly between the groups ( p < 0.001). Of the 39 items, 37 were endorsed significantly more often in the autism spectrum disorder group. The total Social Communication Questionnaire score did not vary by age or gender. Internal consistency was excellent (alpha = 0.92). In the receiver operating characteristic analysis, the area under the curve for the total score showed excellent discrimination between autism spectrum disorder and typically developing children (area under the curve = 0.95; 95% confidence interval: 0.93–0.97). The areas under the curve for the scale subscores were 0.923 (95% confidence interval: 0.898–0.949) for the social interaction score, 0.872 (95% confidence interval: 0.838–0.905) for the communication score, and 0.856 (95% confidence interval: 0.819–0.893) for the repetitive behaviors score. The findings support the use of the Arabic Social Communication Questionnaire to successfully differentiate children with clinically diagnosed autism spectrum disorder using the established cutoff value for the English version.

Delineating the Profile of Autism Spectrum Disorder Characteristics in Cornelia de Lange and Fragile X Syndromes

2013 ◽  
Vol 118 (1) ◽  
pp. 55-73 ◽  
Author(s):  
Joanna Moss ◽  
Chris Oliver ◽  
Lisa Nelson ◽  
Caroline Richards ◽  
Scott Hall
Keyword(s):  
Autism Spectrum Disorder ◽  
Fragile X Syndrome ◽  
Fragile X ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Cornelia De Lange Syndrome ◽  
Genetic Syndromes ◽  
The Social ◽  
Cornelia De Lange ◽  
Atypical Autism

Abstract An atypical presentation of autism spectrum disorder is noted in Cornelia de Lange and Fragile X syndromes, but there are few detailed empirical descriptions. Participants in this study were individuals with Cornelia de Lange syndrome (n  =  130, M age  =  17.19), Fragile X syndrome (n  =  182, M age  =  16.94), and autism spectrum disorder (n  =  142, M age  =  15.19), who were comparable on chronological age. Using the Social Communication Questionnaire, the proportion meeting cutoff for autism spectrum disorder and autism was 78.6%, and 45.6%, respectively, in Cornelia de Lange syndrome and 83.6% and 48.6% in Fragile X syndrome. Domain and item analyses indicate differing, atypical autism spectrum disorder profiles in Fragile X and Cornelia de Lange syndromes. A limited association between adaptive behavior and autism spectrum disorder was identified in all groups. The findings have implications for intervention in genetic syndromes and conceptualization of autism spectrum disorder in the wider population.

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