scholarly journals Glutathione S-transferase A1 polymorphism and the risk of recurrent spontaneous abortion in Chinese Han population

2014 ◽  
Vol 31 (3) ◽  
pp. 379-382
Author(s):  
Chen Zong ◽  
Yanwei Sha ◽  
Huifen Xiang ◽  
Jing Wang ◽  
Dawei Chen ◽  
...  
Keyword(s):  
Spontaneous Abortion ◽  
Chinese Han Population ◽  
Recurrent Spontaneous Abortion ◽  
Glutathione S Transferase ◽  
Chinese Han ◽  
Han Population

scholarly journals Association between Functional Polymorphisms of Foxp3 Gene and the Occurrence of Unexplained Recurrent Spontaneous Abortion in a Chinese Han Population

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Zaigui Wu ◽  
Zeshan You ◽  
Cai Zhang ◽  
Zhuyu Li ◽  
Xiumei Su ◽  
...  
Keyword(s):  
Spontaneous Abortion ◽  
Treg Cells ◽  
Chinese Han Population ◽  
Recurrent Spontaneous Abortion ◽  
Regulatory Function ◽  
Chinese Han ◽  
Han Population ◽  
Foxp3 Gene ◽  
Functional Polymorphisms ◽  
Unexplained Recurrent Spontaneous Abortion

Unexplained recurrent spontaneous abortion (URSA) is an alloimmune disease associated with the failure of fetal-maternal immunologic tolerance in which the regulatory T lymphocytes (Treg) play a pivotal role. It is well known that Forkhead box P3 (Foxp3) is a crucial regulatory factor for the development and function of Treg cells. It has also been established that deficiency of the Foxp3 gene suppresses the regulatory function of Treg cells. To determine if functional polymorphisms at the Foxp3 loci are associated with URSA in humans, we genotyped four common polymorphisms of Foxp3 gene in 146 unrelated URSA patients and 112 healthy women. The results showed that rs3761548A/C and rs2232365A/G polymorphisms were significantly associated with URSA. Additionally, we found that the allelic distribution of rs5902434 del/ATT in URSA group was slightly different from that in the control group. We conclude that functional polymorphisms of the Foxp3 gene may confer an important susceptibility to URSA in the Chinese Han population, probably by altering Foxp3 function and/or its expression.

HLA-G polymorphism in a Chinese Han population with recurrent spontaneous abortion

2006 ◽  
Vol 33 (1) ◽  
pp. 55-58 ◽  
Author(s):  
W. H. Yan ◽  
L. A. Fan ◽  
J. Q. Yang ◽  
L. D. Xu ◽  
Y. Ge ◽  
...  
Keyword(s):  
Spontaneous Abortion ◽  
Chinese Han Population ◽  
Recurrent Spontaneous Abortion ◽  
Chinese Han ◽  
Han Population

scholarly journals Association Between Glutathione S-Transferase (GST) Polymorphisms and Schizophrenia in a Chinese Han Population

2020 ◽  
Vol Volume 16 ◽  
pp. 479-487
Author(s):  
Ci Yan ◽  
Li Duan ◽  
Chunfeng Fu ◽  
Chunsheng Tian ◽  
Bihui Zhang ◽  
...  
Keyword(s):  
Chinese Han Population ◽  
Glutathione S Transferase ◽  
Chinese Han ◽  
Han Population ◽  
Gst Polymorphisms
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