scholarly journals Transcription profile of the insulin-like growth factor signaling pathway during human ovarian follicular development

2019 ◽  
Vol 36 (5) ◽  
pp. 889-903 ◽  
Author(s):  
Jane Alrø Bøtkjær ◽  
Susanne Elisabeth Pors ◽  
Tonny Studsgaard Petersen ◽  
Stine Gry Kristensen ◽  
Janni Vikkelsø Jeppesen ◽  
...  
Keyword(s):  
Growth Factor ◽  
Signaling Pathway ◽  
Follicular Development ◽  
Growth Factor Signaling ◽  
Insulin Like Growth Factor ◽  
Transcription Profile ◽  
Ovarian Follicular Development ◽  
Growth Factor Signaling Pathway

Abstract P5-11-05: Pregnancy-induced epigenetic changes in the insulin-like growth factor signaling pathway

2015 ◽  
Author(s):  
Tiffany A Katz ◽  
Serena G Liao ◽  
Thushangi Pathiraja ◽  
Robert K Dearth ◽  
George C Tseng ◽  
...  
Keyword(s):  
Growth Factor ◽  
Signaling Pathway ◽  
Growth Factor Signaling ◽  
Insulin Like Growth Factor ◽  
Epigenetic Changes ◽  
Growth Factor Signaling Pathway

scholarly journals Genetic manipulation of insulin/insulin-like growth factor signaling pathway activity has sex-biased effects on Drosophila body size

2020 ◽  
Author(s):  
Jason W. Millington ◽  
George P. Brownrigg ◽  
Paige J. Basner-Collins ◽  
Ziwei Sun ◽  
Elizabeth J. Rideout
Keyword(s):  
Body Size ◽  
Growth Factor ◽  
Signaling Pathway ◽  
Larval Growth ◽  
Growth Factor Signaling ◽  
Insulin Like Growth Factor ◽  
Male Body ◽  
Pathway Activity ◽  
Specific Regulation ◽  
Growth Factor Signaling Pathway

ABSTRACTIn Drosophila, female body size is approximately 30% larger than male body size due to an increased rate of larval growth. While the mechanisms that control this sex difference in body size remain incompletely understood, recent studies suggest that the insulin/insulin-like growth factor signaling pathway (IIS) plays a role in the sex-specific regulation of growth during development. In larvae, IIS activity differs between the sexes, and there is evidence of sex-specific regulation of IIS ligands. Yet, we lack knowledge of how changes to IIS activity impact growth in each sex, as the majority of studies on IIS and body size use single- or mixed-sex groups of larvae and/or adult flies. The goal of our current study was to clarify the requirement for IIS activity in each sex during the larval growth period. To achieve this goal we used established genetic approaches to enhance, or inhibit, IIS activity, and quantified body size in male and female larvae. Overall, genotypes that inhibited IIS activity caused a female-biased decrease in body size, whereas genotypes that augmented IIS activity caused a male-specific increase in body size. This data extends our current understanding of larval growth by showing that most changes to IIS pathway activity have sex-biased effects on body size, and highlights the importance of analyzing data by sex in larval growth studies.

scholarly journals Genetic manipulation of insulin/insulin-like growth factor signaling pathway activity has sex-biased effects on Drosophila body size

2021 ◽  
Author(s):  
Jason W Millington ◽  
George P Brownrigg ◽  
Paige J Basner-Collins ◽  
Ziwei Sun ◽  
Elizabeth J Rideout
Keyword(s):  
Body Size ◽  
Growth Factor ◽  
Signaling Pathway ◽  
The Body ◽  
Growth Factor Signaling ◽  
Insulin Like Growth Factor ◽  
Male Body ◽  
Pathway Activity ◽  
Specific Regulation ◽  
Growth Factor Signaling Pathway

Abstract In Drosophila raised in nutrient-rich conditions female body size is approximately 30% larger than male body size due to an increased rate of growth and differential weight loss during the larval period. While the mechanisms that control this sex difference in body size remain incompletely understood, recent studies suggest that the insulin/insulin-like growth factor signaling pathway (IIS) plays a role in the sex-specific regulation of processes that influence body size during development. In larvae, IIS activity differs between the sexes, and there is evidence of sex-specific regulation of IIS ligands. Yet, we lack knowledge of how changes to IIS activity impact body size in each sex, as the majority of studies on IIS and body size use single- or mixed-sex groups of larvae and/or adult flies. The goal of our current study was to clarify the body size requirement for IIS activity in each sex. To achieve this goal we used established genetic approaches to enhance, or inhibit, IIS activity, and quantified pupal size in males and females. Overall, genotypes that inhibited IIS activity caused a female-biased decrease in body size, whereas genotypes that augmented IIS activity caused a male-specific increase in body size. This data extends our current understanding of body size regulation by showing that most changes to IIS pathway activity have sex-biased effects, and highlights the importance of analyzing body size data according to sex.

The Sirt1 deacetylase modulates the insulin-like growth factor signaling pathway in mammals

2005 ◽  
Vol 126 (10) ◽  
pp. 1097-1105 ◽  
Author(s):  
M.E. Lemieux ◽  
X. Yang ◽  
K. Jardine ◽  
X. He ◽  
K.X. Jacobsen ◽  
...  
Keyword(s):  
Growth Factor ◽  
Signaling Pathway ◽  
Growth Factor Signaling ◽  
Insulin Like Growth Factor ◽  
Growth Factor Signaling Pathway

Insulin-like Growth Factor Signaling Pathway Involved in Regulating Longevity of Rotifers

Hydrobiologia ◽  
2005 ◽  
Vol 546 (1) ◽  
pp. 347-352 ◽  
Author(s):  
Tatsuki Yoshinaga ◽  
Gen Kaneko ◽  
Shigeharu Kinoshita ◽  
Satoshi Furukawa ◽  
Katsumi Tsukamoto ◽  
...  
Keyword(s):  
Growth Factor ◽  
Signaling Pathway ◽  
Growth Factor Signaling ◽  
Insulin Like Growth Factor ◽  
Growth Factor Signaling Pathway

Insulin-like growth factor signaling pathway involved in regulating longevity of rotifers

2006 ◽  
pp. 347-352
Author(s):  
Tatsuki Yoshinaga ◽  
Gen Kaneko ◽  
Shigeharu Kinoshita ◽  
Satoshi Furukawa ◽  
Katsumi Tsukamoto ◽  
...  
Keyword(s):  
Growth Factor ◽  
Signaling Pathway ◽  
Growth Factor Signaling ◽  
Insulin Like Growth Factor ◽  
Growth Factor Signaling Pathway

scholarly journals Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway

2008 ◽  
Vol 29 (7) ◽  
pp. 1319-1326 ◽  
Author(s):  
Wei Cheng ◽  
Chia-Jen Tseng ◽  
Tom T.C. Lin ◽  
I. Cheng ◽  
Hung-Wei Pan ◽  
...  
Keyword(s):  
Growth Factor ◽  
Signaling Pathway ◽  
Growth Factor Signaling ◽  
Insulin Like Growth Factor ◽  
Growth Factor Signaling Pathway
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