Nasal in situ gel containing hydroxy propyl β-cyclodextrin inclusion complex of artemether: development and in vitro evaluation

2010 ◽  
Vol 70 (1-2) ◽  
pp. 49-58 ◽  
Author(s):  
Hitendra S. Mahajan ◽  
Saurabh K. Shah ◽  
Sanjay J. Surana
Keyword(s):  
Inclusion Complex ◽  
In Situ Gel ◽  
In Vitro Evaluation ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex

Characterization of a new TiF4 and β-cyclodextrin inclusion complex and its in vitro evaluation on inhibiting enamel demineralization

2013 ◽  
Vol 58 (3) ◽  
pp. 239-247 ◽  
Author(s):  
Camila Nassur ◽  
Adílis Kalina Alexandria ◽  
Luciana Pomarico ◽  
Valeria Pereira de Sousa ◽  
Lúcio Mendes Cabral ◽  
...  
Keyword(s):  
Inclusion Complex ◽  
In Vitro Evaluation ◽  
Enamel Demineralization ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex

BEHAVIOURAL STUDY OF CYCLODEXTRIN INCLUSION COMPLEX ON ENHANCEMENT OF SOLUBILITY OF ACECLOFENAC

INDIAN DRUGS ◽  
2015 ◽  
Vol 52 (11) ◽  
pp. 19-23
Author(s):  
J Shaikh ◽  
◽  
S. V. Deshmane ◽  
R. N Purohit ◽  
K. R. Biyani
Keyword(s):  
Inclusion Complex ◽  
Solid Dispersion ◽  
Water Soluble ◽  
In Vitro Dissolution ◽  
Phase Solubility ◽  
Solubility Study ◽  
Cyclodextrin Inclusion ◽  
Poorly Water Soluble ◽  
Cyclodextrin Inclusion Complex

The main objective of the present study was to enhance the solubility and dissolution rate of poorly water soluble aceclofenac using its solid dispersion with β-cyclodextrin. FTIR and DSC study was carried out to find out any incompatibility. The phase solubility of drug was carried out in 1, 2, 5, and 10% of β-cyclodextrin in distilled water. Kneading method and solvent evaporation method was use to prepared solid dispersion of aceclofenac and β-cyclodextrin. Different evaluation tests like solubility study in different solvents, PXRD and in vitro dissolution study of aceclofenac- β-cyclodextrin inclusion complex were carried out. The overall finding indicated that β-cyclodextrin is a desirable water soluble carrier, that helps in increasing solubility of drug. Due to its structural feature, β-cyclodextrin forms a good inclusion complex that decreases contact angle of drug with water molecules by increasing wetting properties. Hence, it can be concluded that, β-cyclodextrin is better water soluble carrier molecule in terms of its compatibility and increasing solubility behavior of poorly water soluble drug aceclofenac.

scholarly journals Delineating the behavior of Berberis anthocyanin/β-cyclodextrin inclusion complex in vitro: A molecular dynamics approach

LWT ◽  
2022 ◽  
pp. 113090
Author(s):  
Prakash Chandra Pradhan ◽  
Abhishek Mandal ◽  
Anirban Dutta ◽  
Rohan Sarkar ◽  
Aditi Kundu ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Inclusion Complex ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex

FORMULATION AND IN-VITRO EVALUATION OF ZOLMITRIPTAN IN SITU GEL FOR NASAL ADMINISTRATION

INDIAN DRUGS ◽  
2013 ◽  
Vol 50 (12) ◽  
pp. 54-58
Author(s):  
P. H Patil ◽  
◽  
V. S Belgamwar ◽  
D. A Patel ◽  
S. J. Surana
Keyword(s):  
Evaluation Studies ◽  
Methyl Cellulose ◽  
Nasal Delivery ◽  
Nasal Administration ◽  
Histopathological Study ◽  
In Situ Gel ◽  
In Vitro Evaluation ◽  
Effective Delivery

The aim of present investigation was formulation and in-vitro evaluation of in situ gel for the nasal delivery of zolmitriptan. The in situ gel was prepared by temperature induced gelation technique using Pluronic with mucoadhesive polymer hydroxy propyl methyl cellulose K4 M in different ratios. The in situ gels so prepared were characterized and from the evaluation studies, batch PH2 was optimized and further subjected for stability studies at 30±2°C and 60±5% RH for 90 days. These formulations retained good stability at accelerated conditions and also did not show any remarkable damage to nasal mucosa in histopathological study. Owing to these properties it can be used as an effective delivery system for the nasal route.

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