Recyclable heparin and chitosan conjugated magnetic nanocomposites for selective removal of low-density lipoprotein from plasma

2014 ◽  
Vol 25 (4) ◽  
pp. 1055-1064 ◽  
Author(s):  
Jinghua Li ◽  
Yanhua Hou ◽  
Xiuyong Chen ◽  
Xingwei Ding ◽  
Yun Liu ◽  
...  
2016 ◽  
Vol 31 (suppl_1) ◽  
pp. i229-i229
Author(s):  
Liu Qiang ◽  
Sun Si ◽  
Yang Tingting ◽  
Han Mei ◽  
Lin Liping ◽  
...  

2004 ◽  
Vol 32 (2) ◽  
pp. 303-313 ◽  
Author(s):  
Guoqi Fu ◽  
Haofeng Yu ◽  
Zhi Yuan ◽  
Bin Liu ◽  
Bin Shen ◽  
...  

1995 ◽  
Vol 114 (2) ◽  
pp. 203-211 ◽  
Author(s):  
Daniel M. Lane ◽  
Walter J. McConathy ◽  
L.O. Laughlin ◽  
Philip C. Comp ◽  
Beat von Albertini ◽  
...  

Author(s):  
Dean A. Handley ◽  
Cynthia M. Arbeeny ◽  
Larry D. Witte

Low density lipoproteins (LDL) are the major cholesterol carrying particles in the blood. Using cultured cells, it has been shown that LDL particles interact with specific surface receptors and are internalized via a coated pit-coated vesicle pathway for lysosomal catabolism. This (Pathway has been visualized using LDL labeled to ferritin or colloidal gold. It is now recognized that certain lysomotropic agents, such as chloroquine, inhibit lysosomal enzymes that degrade protein and cholesterol esters. By interrupting cholesterol ester hydrolysis, chloroquine treatment results in lysosomal accumulation of cholesterol esters from internalized LDL. Using LDL conjugated to colloidal gold, we have examined the ultrastructural effects of chloroquine on lipoprotein uptake by normal cultured fibroblasts.


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