Dual Threat of Epstein-Barr Virus: an Autopsy Case Report of HIV-Positive Plasmablastic Lymphoma Complicating EBV-Associated Hemophagocytic Lymphohistiocytosis

2018 ◽  
Vol 38 (4) ◽  
pp. 478-483 ◽  
Author(s):  
Yusuke Koizumi ◽  
Ken-Ichi Imadome ◽  
Yasunori Ota ◽  
Hitoshi Minamiguchi ◽  
Yoshinori Kodama ◽  
...  
Keyword(s):  
Case Report ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Epstein Barr Virus ◽  
Plasmablastic Lymphoma ◽  
Hiv Positive ◽  
Autopsy Case ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Epstein–Barr Virus Primary Infection Complicated by Hemophagocytic Lymphohistiocytosis and Plasmablastic Lymphoma in a HIV-Negative Patient

2019 ◽  
Vol 2019 ◽  
pp. 1-4 ◽  
Author(s):  
Nan Chen ◽  
Mike Perez ◽  
Martha Mims
Keyword(s):  
Bone Marrow ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Epstein Barr Virus ◽  
Killer Cell ◽  
High Volume ◽  
Immune Dysregulation ◽  
Gastric Biopsy ◽  
Plasmablastic Lymphoma ◽  
Barr Virus ◽  
Epstein Barr

EBV (Epstein–Barr virus) viremia causes immune dysregulation through various mechanisms, and we are understanding more that mutations in B, T, and NK (natural killer) cell signaling pathways allow EBV complications such as HLH (hemophagocytic lymphohistiocytosis) and lymphomas to arise. Here, we report a 20-year-old previously healthy, HIV- (human immunodeficiency virus-) negative male who presented with fevers, sore throat, and lymphadenopathy (LAD). He was found to have EBV viremia, pancytopenia, and elevated LFTs (liver function tests) suspicious for HLH. Bone marrow biopsy and elevated IL-2 (interleukin) receptor confirmed this diagnosis. Additionally, gastric biopsy confirmed diagnosis of plasmablastic lymphoma (PBL), a rare, aggressive HIV- and EBV-associated lymphoma. Both bone marrow and gastric biopsy showed evidence of EBV. Patients with EBV complications should have a rigorous workup to characterize the full extent of immune dysregulation including genetic testing at a high-volume center.

scholarly journals The efficacy of HA330-II column hemoadsorption in Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis combined with liver failure: a case report

2021 ◽  
Author(s):  
Qian Gao ◽  
Xiaowei Xin ◽  
Chun Zhao ◽  
Yujuan Wang ◽  
Wei Wang ◽  
...  
Keyword(s):  
Case Report ◽  
Liver Failure ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Epstein Barr Virus ◽  
Multiple Organ ◽  
Clinical Experiences ◽  
Organ Function ◽  
Barr Virus ◽  
Ifn Γ ◽  
Epstein Barr

BACKGROUND Hemophagocytic lymphohistiocytosis (HLH) is a severe and potentially deadly condition associated with extensive inflammation and immune activation. Cytokine adsorption may serve as a supportive treatment that can stabilize organ function in affected patients by reducing their circulating cytokines levels. To date, no descriptions of clinical experiences associated with the use of HA330-II column hemoadsorption for the treatment of HLH children have been published. CASE SUMMARY We describe a 11-year-old children with Epstein-Barr virus (EBV)-associated HLH combined with liver failure. She underwent HA330-II column hemoadsorption and chemotherapy, and developed a decreased inflammatory cytokines including interleukin (IL)-6, IL-8, IL-10, and interferon (IFN)-γ. The patient’ condition and laboratory parameters gradually improved. CONCLUSION Hemoadsorption may play an important role in eliminating cytokines storm in children with Hemophagocytic lymphohistiocytosis combined with liver failure and consequent multiple organ failure. Keywords: hemoadsorption; HA330-II column; Hemophagocytic lymphohistiocytosis; Pediatric; Liver failure; Case report

scholarly journals PLasmablastic lymphoma with coinfection by Epstein Barr Virus and Herpes Human Virus 8: a case report

2019 ◽  
Vol 104 (808) ◽  
pp. 188-190
Author(s):  
Juan Daniel Díaz-García ◽  
◽  
Juan Pablo Venzor-Castellanos ◽  
Karen Hopf-Estandia ◽  
Eunice Rojas-Zaldívar ◽  
...  
Keyword(s):  
Case Report ◽  
Epstein Barr Virus ◽  
Plasmablastic Lymphoma ◽  
Human Virus ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Successful Use of Etoposide for Severe Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis in an Adult：A Case Report

2019 ◽  
Vol 39 (5) ◽  
pp. 504-509
Author(s):  
Mari OTSUJI ◽  
Motoki FUJITA ◽  
Ichiko MIZUGUCHI ◽  
Takeshi YAGI ◽  
Kotaro KANEDA ◽  
...  
Keyword(s):  
Case Report ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr

Fistulizing Epstein-Barr virus-positive plasmablastic lymphoma in an HIV-positive man

2015 ◽  
Vol 174 (2) ◽  
pp. 398-401 ◽  
Author(s):  
J. Rangel ◽  
R. Novoa ◽  
C. Morrison ◽  
D. Frank ◽  
C. Kovarik
Keyword(s):  
Epstein Barr Virus ◽  
Plasmablastic Lymphoma ◽  
Hiv Positive ◽  
Barr Virus ◽  
Epstein Barr
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