Activation of PPARδ up-regulates the expression of insulin gene transcription factor MafA and ameliorates glucose-induced insulin secretion impaired by palmitate

2012 ◽  
Vol 366 (1-2) ◽  
pp. 183-189 ◽  
Author(s):  
Mingming Cao ◽  
Yang Long ◽  
Yuzhen Tong ◽  
Jun Wan ◽  
Nanwei Tong
Keyword(s):  
Transcription Factor ◽  
Insulin Secretion ◽  
Gene Transcription ◽  
Insulin Gene ◽  
Insulin Gene Transcription

Short-term regulation of insulin gene transcription

2002 ◽  
Vol 30 (2) ◽  
pp. 312-317 ◽  
Author(s):  
B. Leibiger ◽  
T. Moede ◽  
S. Uhles ◽  
P.-O. Berggren ◽  
I. B. Leibiger
Keyword(s):  
Insulin Secretion ◽  
Gene Transcription ◽  
Insulin Gene ◽  
Current View ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Short Term ◽  
Major Nutrient ◽  
Glucose Metabolites ◽  
Insulin Gene Transcription

Short-term regulation of insulin gene transcription is still a matter of debate. However, an increasing body of evidence shows that insulin gene transcription is affected by signals, such as incretins, glucose metabolites, intracellular Ca2+, and by insulin secreted from pancreatic β-cells, all supporting the concept of an immediate response resulting in insulin gene transcription following food-uptake. The present review aims to summarize the current view on the mechanisms underlying the up-regulation of insulin gene transcription in response to glucose, the major nutrient factor in insulin secretion and biosynthesis.

scholarly journals XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor.

1994 ◽  
Vol 8 (6) ◽  
pp. 806-816
Author(s):  
M Peshavaria ◽  
L Gamer ◽  
E Henderson ◽  
G Teitelman ◽  
C V Wright ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Gene Transcription ◽  
Insulin Gene ◽  
Homeodomain Protein ◽  
Insulin Gene Transcription
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