Memory impairment of chewing-side preference mice is associated with 5-HT-BDNF signal pathway

2020 ◽  
Author(s):  
Hua Jiang ◽  
Hong Yin ◽  
Lin Wang ◽  
Chunzhen Feng ◽  
Yang Bai ◽  
...  
Keyword(s):  
Memory Impairment ◽  
Signal Pathway ◽  
Side Preference

The Effects and Regulative Mechanism of Scutellaria Baicalensis Georgi Stems and Leaves Flavonoids in Promoting Neurogenesis and Improving Memory Impairment Mediated by BDNF-ERK-CREB Signal Pathway in Rats

2021 ◽  
Vol 20 ◽  
Author(s):  
Yazhen Shang ◽  
Shengkai Ding ◽  
Qianqian Liu
Keyword(s):  
Cerebral Cortex ◽  
Protein Expression ◽  
Signaling Pathway ◽  
Memory Impairment ◽  
Signal Pathway ◽  
Scutellaria Baicalensis ◽  
Scutellaria Baicalensis Georgi ◽  
Mrna And Protein Expression ◽  
Stems And Leaves ◽  
Regulative Mechanism

Background: It is well known that Alzheimer's disease (AD) is a degenerative disease, and accompanied by memory impairment and main pathological changes of the extracellular senile plaque (SP) and intracellular neurofibrillary tangles (NFTs). However, there are many evidences showing that the disorders of neurogenesis are also regarded as a new opinion in AD. Objective: To investigate the effects and regulative mechanism of Scutellaria baicalensis Georgi stems and leaves flavonoids in promoting neurogenesis and improving memory impairment mediated by BDNF-ERK-CREB signal pathway in rats. Methods: Male Wistar rats were intracerebroventricularly injected with amyloid-beta protein 25-35 (Aβ25-35) in combination with aluminum trichloride (AlCl3) and recombinant human transforming growth factor-β1 (RHTGF-β1) (composited Aβ), to establish an AD model. Morris water maze was used to screen AD model of rats and measure the rats’ learning and memory ability. The expression of cell neurogenesis related molecule Ki67 protein in the hippocampal gyrus of rats was detected by the immunohistochemical method. The expression of mRNA and protein of Grb2, SOS1, Ras, ERK and BDNF in the BDNF-ERK-CREB signaling pathway, in the hippocampus and cerebral cortex were assayed by the Quantitative real-time PCR (qPCR) and Western blotting methods, respectively. Results: Intracerebroventricular injection of composited Aβ could produce the rats’ memory impairment, decrease the protein expression of Ki67 in the hippocampal gyrus, and increase the mRNA and protein expression levels of Grb2, SOS1, Ras, ERK and BDNF in the hippocampus and cerebral cortex. However, SSF could significantly ameliorate the rats’ memory impairment, lower the reduction of Ki67 protein expression in the hippocampal gyrus and regulate the mRNA and protein expression abnormal levels of Grb2, SOS1, Ras, ERK and BDNF in the hippocampus and cerebral cortex induced by composited Aβ. Conclusion: Composited Aβ can result in memory impairment, decrease neurogenesis and regulate the mRNA and protein abnormal expression of Grb2, SOS1, Ras, ERK and BDNF in BDNF-ERK-CREB signaling pathway. The effects of SSF in promoting neurogenesis and improving memory impairment may be related to the regulation in Grb2, SOS1, Ras, ERK and BDNF molecules’ expression of the BDNF-ERK-CREB signaling pathway.

Rosiglitazone Attenuates Memory Impairment in Aged Rat with Diabetes by Inhibiting NF-kappa B Signal Pathway Activation

2015 ◽  
Vol 123 (09) ◽  
pp. 536-542 ◽  
Author(s):  
L. Fei ◽  
H. Yong-Jun ◽  
M. Zhang-Min ◽  
X. Bing ◽  
W. Shuang ◽  
...  
Keyword(s):  
Memory Impairment ◽  
Signal Pathway ◽  
Nf Kappa B ◽  
Aged Rat ◽  
Pathway Activation

Assessment of Memory Impairment Associated With Aging

1989 ◽  
Vol 34 (1) ◽  
pp. 69-70
Author(s):  
Marion Perlmutter
Keyword(s):  
Memory Impairment

Ethanol-Induced Memory Impairment and Post-Intoxication Facilitation of Memory

2003 ◽  
Author(s):  
Patricia L. Moulton ◽  
Thomas V. Petros ◽  
Kathryn J. Apostal ◽  
Ronald V. Park ◽  
Elizabeth A. Ronning ◽  
...  
Keyword(s):  
Memory Impairment

Older age exacerbates prospective memory impairment in HIV

2008 ◽  
Author(s):  
Steven P. Woods ◽  
◽  
Catherine L. Carey ◽  
Matthew S. Dawson ◽  
Lisa M. Moran ◽  
...  
Keyword(s):  
Prospective Memory ◽  
Memory Impairment ◽  
Older Age ◽  
Prospective Memory Impairment

The Role of Attention in Episodic Memory Impairment During Nicotine Withdrawal

2007 ◽  
Author(s):  
Paul S. Merritt ◽  
Adam Cobb ◽  
Luke Moissinac ◽  
Corpus Christi ◽  
Elliot Hirshman
Keyword(s):  
Episodic Memory ◽  
Memory Impairment ◽  
Nicotine Withdrawal
Sign in / Sign up

Export Citation Format

Share Document