Large-scale structure-activity relationship study of hepatitis C virus NS5B polymerase inhibition using SMILES-based descriptors

2015 ◽  
Vol 19 (4) ◽  
pp. 955-964 ◽  
Author(s):  
Apilak Worachartcheewan ◽  
Virapong Prachayasittikul ◽  
Alla P. Toropova ◽  
Andrey A. Toropov ◽  
Chanin Nantasenamat
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Large Scale ◽  
Large Scale Structure ◽  
Structure Activity Relationship ◽  
Scale Structure ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Study ◽  
Ns5b Polymerase

Structure–Activity Relationship (SAR) Development and Discovery of Potent Indole-Based Inhibitors of the Hepatitis C Virus (HCV) NS5B Polymerase

2012 ◽  
Vol 55 (2) ◽  
pp. 754-765 ◽  
Author(s):  
Kevin X. Chen ◽  
Bancha Vibulbhan ◽  
Weiying Yang ◽  
Mousumi Sannigrahi ◽  
Francisco Velazquez ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Hcv Ns5b ◽  
Ns5b Polymerase

Structure−Activity Relationship of Purine Ribonucleosides for Inhibition of Hepatitis C Virus RNA-Dependent RNA Polymerase

2004 ◽  
Vol 47 (9) ◽  
pp. 2283-2295 ◽  
Author(s):  
Anne B. Eldrup ◽  
Charles R. Allerson ◽  
C. Frank Bennett ◽  
Sanjib Bera ◽  
Balkrishen Bhat ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Rna Polymerase ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Hepatitis C Virus Rna ◽  
Rna Dependent Rna Polymerase ◽  
Structure Activity ◽  
Virus Rna ◽  
Relationship Of

Imidazopyridazine Hepatitis C Virus Polymerase Inhibitors. Structure–Activity Relationship Studies and the Discovery of a Novel, Traceless Prodrug Mechanism

2013 ◽  
Vol 57 (5) ◽  
pp. 1964-1975 ◽  
Author(s):  
Martin Leivers ◽  
John F. Miller ◽  
Stephanie A. Chan ◽  
Ryan Lauchli ◽  
Sebastian Liehr ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Polymerase Inhibitors ◽  
Structure Activity
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