Benzimidazole Derivatives Bearing Substituted Biphenyls as Hepatitis C Virus NS5B RNA-Dependent RNA Polymerase Inhibitors:  Structure−Activity Relationship Studies and Identification of a Potent and Highly Selective Inhibitor JTK-109

2006 ◽  
Vol 49 (15) ◽  
pp. 4721-4736 ◽  
Author(s):  
Shintaro Hirashima ◽  
Takayoshi Suzuki ◽  
Tomio Ishida ◽  
Satoru Noji ◽  
Shinji Yata ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Rna Polymerase ◽  
Structure Activity Relationship ◽  
Selective Inhibitor ◽  
Activity Relationship ◽  
Benzimidazole Derivatives ◽  
Rna Dependent Rna Polymerase ◽  
Polymerase Inhibitors ◽  
Structure Activity

Large-scale structure-activity relationship study of hepatitis C virus NS5B polymerase inhibition using SMILES-based descriptors

2015 ◽  
Vol 19 (4) ◽  
pp. 955-964 ◽  
Author(s):  
Apilak Worachartcheewan ◽  
Virapong Prachayasittikul ◽  
Alla P. Toropova ◽  
Andrey A. Toropov ◽  
Chanin Nantasenamat
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Large Scale ◽  
Large Scale Structure ◽  
Structure Activity Relationship ◽  
Scale Structure ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Study ◽  
Ns5b Polymerase
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