Benzimidazole Derivatives Bearing Substituted Biphenyls as Hepatitis C Virus NS5B RNA-Dependent RNA Polymerase Inhibitors:  Structure−Activity Relationship Studies and Identification of a Potent and Highly Selective Inhibitor JTK-109

2006 ◽  
Vol 49 (15) ◽  
pp. 4721-4736 ◽  
Author(s):  
Shintaro Hirashima ◽  
Takayoshi Suzuki ◽  
Tomio Ishida ◽  
Satoru Noji ◽  
Shinji Yata ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Rna Polymerase ◽  
Structure Activity Relationship ◽  
Selective Inhibitor ◽  
Activity Relationship ◽  
Benzimidazole Derivatives ◽  
Rna Dependent Rna Polymerase ◽  
Polymerase Inhibitors ◽  
Structure Activity

Structure−Activity Relationship of Purine Ribonucleosides for Inhibition of Hepatitis C Virus RNA-Dependent RNA Polymerase

2004 ◽  
Vol 47 (9) ◽  
pp. 2283-2295 ◽  
Author(s):  
Anne B. Eldrup ◽  
Charles R. Allerson ◽  
C. Frank Bennett ◽  
Sanjib Bera ◽  
Balkrishen Bhat ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Rna Polymerase ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Hepatitis C Virus Rna ◽  
Rna Dependent Rna Polymerase ◽  
Structure Activity ◽  
Virus Rna ◽  
Relationship Of

Imidazopyridazine Hepatitis C Virus Polymerase Inhibitors. Structure–Activity Relationship Studies and the Discovery of a Novel, Traceless Prodrug Mechanism

2013 ◽  
Vol 57 (5) ◽  
pp. 1964-1975 ◽  
Author(s):  
Martin Leivers ◽  
John F. Miller ◽  
Stephanie A. Chan ◽  
Ryan Lauchli ◽  
Sebastian Liehr ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Polymerase Inhibitors ◽  
Structure Activity

Structure-Activity Relationships in the Development of Allosteric Hepatitis C Virus RNA-Dependent RNA Polymerase Inhibitors: Ten Years of Research

2012 ◽  
Vol 33 (5) ◽  
pp. 934-984 ◽  
Author(s):  
Romain Haudecoeur ◽  
Marine Peuchmaur ◽  
Abdelhakim Ahmed-Belkacem ◽  
Jean-Michel Pawlotsky ◽  
Ahcène Boumendjel
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Rna Polymerase ◽  
Hepatitis C Virus Rna ◽  
Rna Dependent Rna Polymerase ◽  
Structure Activity Relationships ◽  
Polymerase Inhibitors ◽  
Structure Activity ◽  
Virus Rna

Large-scale structure-activity relationship study of hepatitis C virus NS5B polymerase inhibition using SMILES-based descriptors

2015 ◽  
Vol 19 (4) ◽  
pp. 955-964 ◽  
Author(s):  
Apilak Worachartcheewan ◽  
Virapong Prachayasittikul ◽  
Alla P. Toropova ◽  
Andrey A. Toropov ◽  
Chanin Nantasenamat
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Large Scale ◽  
Large Scale Structure ◽  
Structure Activity Relationship ◽  
Scale Structure ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Study ◽  
Ns5b Polymerase
Sign in / Sign up

Export Citation Format

Share Document