Accelerating near-field 3D imaging approach for joint high-resolution imaging and phase error correction

2017 ◽  
Vol 30 (1) ◽  
pp. 69-92
Author(s):  
Yang Fang ◽  
Baoping Wang ◽  
Chao Sun ◽  
Zuxun Song ◽  
Shuzhen Wang
1995 ◽  
pp. 123-132 ◽  
Author(s):  
Th. Lacoste ◽  
Th. Huser ◽  
H. Heinzelmann ◽  
H.-J. Güntherodt

2017 ◽  
Vol 65 (2) ◽  
pp. 989-994 ◽  
Author(s):  
Kai Tan ◽  
Shiyou Wu ◽  
Youcheng Wang ◽  
Shengbo Ye ◽  
Jie Chen ◽  
...  

Cell ◽  
2015 ◽  
Vol 163 (1) ◽  
pp. 246-255 ◽  
Author(s):  
Michael W. Linhoff ◽  
Saurabh K. Garg ◽  
Gail Mandel

2004 ◽  
Vol 93 (20) ◽  
Author(s):  
Heinrich G. Frey ◽  
Susanne Witt ◽  
Karin Felderer ◽  
Reinhard Guckenberger

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Mirela Balan ◽  
Marta Trusohamn ◽  
Frank Chenfei Ning ◽  
Stefan Jacob ◽  
Kristian Pietras ◽  
...  

Abstract Preclinical trials of cancer drugs in animal models are important for drug development. The Rip1Tag2 (RT2) transgenic mouse, a model of pancreatic neuroendocrine tumours (PNET), has provided immense knowledge about PNET biology, although tumour progression occurs in a location inaccessible for real-time monitoring. To overcome this hurdle we have developed a novel platform for intravital 3D imaging of RT2 tumours to facilitate real-time studies of cancer progression. Pre-oncogenic islets retrieved from RT2 mice were implanted into the anterior chamber of the eye (ACE) of host mice, where they engrafted on the iris, recruited blood vessels and showed continuous growth. Noninvasive confocal and two-photon laser-scanning microscopy through the transparent cornea facilitated high-resolution imaging of tumour growth and angiogenesis. RT2 tumours in the ACE expanded up to 8-fold in size and shared hallmarks with tumours developing in situ in the pancreas. Genetically encoded fluorescent reporters enabled high-resolution imaging of stromal cells and tumour cell migration. Sunitinib treatment impaired RT2 tumour angiogenesis and growth, while overexpression of the vascular endothelial growth factor (VEGF)-B increased tumour angiogenesis though tumour growth was impaired. In conclusion, we present a novel platform for intravital high-resolution and 3D imaging of PNET biology and cancer drug assessment.


2017 ◽  
Vol 56 (11) ◽  
pp. 3132 ◽  
Author(s):  
Sandeep Inampudi ◽  
Jierong Cheng ◽  
Hossein Mosallaei

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