Theranostic multimodal potential of magnetic nanoparticles actuated by non-heating low frequency magnetic field in the new-generation nanomedicine

2017 ◽  
Vol 19 (2) ◽  
Author(s):  
Yuri I. Golovin ◽  
Natalia L. Klyachko ◽  
Alexander G. Majouga ◽  
Marina Sokolsky ◽  
Alexander V. Kabanov

The main objective of this article is to develop the basic technological principles of production of the magnetosensitive layer based on nematic liquid crystals with magnetic nanoparticles as the main component of the system, which allows obtaining a two-dimensional picture of the inhomogeneous distribution of low-frequency magnetic field and to identify the object creating this field. In work are described physical methods which allow to increase sensitivity and to expand a working frequency range of the magneto-sensitive layer based on such liquid crystals. By us it has been shown, that the time of reorientation of director in oriented liquid crystals with magnetic nanoparticles is less than the analogous reorientation time in nonoriented crystals. In work also it is shown, that to significantly increase the speed of reorientation in a magnetic field of the director of liquid crystals with magnetic nanoparticles is possible if submitting an additional magnetic field with given amplitude. This method allows to increase sensitivity to a magnetic field and to receive parametrical amplification of signals in liquid crystals with magnetic nanoparticles. In the conclusion on the basis of liquid crystals with magnetic nanoparticles the scheme of system of detection of inhomogeneous magnetic field is described.


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