Logarithmic decrease of serum alpha-fetoprotein or human chorionic gonadotropin in response to chemotherapy can distinguish a subgroup with better prognosis among highly malignant intracranial non-germinomatous germ cell tumors

2011 ◽  
Vol 104 (3) ◽  
pp. 779-787 ◽  
Author(s):  
Tomohiro Kawaguchi ◽  
Toshihiro Kumabe ◽  
Masayuki Kanamori ◽  
Ryuta Saito ◽  
Yoji Yamashita ◽  
...  
Keyword(s):  
Germ Cell ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Germ Cell Tumors ◽  
Alpha Fetoprotein ◽  
Response To Chemotherapy ◽  
Serum Alpha Fetoprotein

Serum and Cerebrospinal Fluid Human Chorionic Gonadotropin (hCG) and alpha-fetoprotein (AFP) in Intracranial Germ Cell Tumors

2002 ◽  
Vol 17 (2) ◽  
pp. 112-118 ◽  
Author(s):  
E. Seregni ◽  
M. Massimino ◽  
S. Nerini Molteni ◽  
F. Pallotti ◽  
B. van der Hiel ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Germ Cell ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Germ Cell Tumors ◽  
High Serum ◽  
Response To Therapy ◽  
Alpha Fetoprotein ◽  
Intracranial Germ Cell Tumors

We report a retrospective study on serum and cerebrospinal fluid (CSF) alpha-fetoprotein (AFP) and β-human chorionic gonadotropin (βhCG) determination in a series of 30 patients bearing intracranial germ cell tumors. At diagnosis five patients had high serum and CSF AFP levels. No patient had positive serum AFP and negative CSF AFP or vice versa. Twelve of 30 patients had serum βhCG levels above 5 mIU/mL, eight had high βhCG only in CSF, and ten were completely negative. During treatment and follow-up both markers were accurate indicators of the response to therapy, decreasing rapidly and often becoming normal already after the first phase of treatment. We conclude that these two markers, and mostly βhCG, may be useful in the diagnosis and monitoring of the response to therapy of patients with intracranial germ cell tumors.

Hyperthyroidism in men with germ cell tumors and high levels of beta-human chorionic gonadotropin

Cancer ◽  
2010 ◽  
Vol 69 (5) ◽  
pp. 1286-1290 ◽  
Author(s):  
Sergio A. Giralt ◽  
Francisco Dexeus ◽  
Robert Amato ◽  
Avishay Sella ◽  
Christopher Logothetis
Keyword(s):  
Germ Cell ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Germ Cell Tumors ◽  
Beta Human Chorionic Gonadotropin

Affinity chromatography used in distinguishing alpha-fetoprotein in serum from patients with tumors of hepatic parenchyma and of germ cells.

1984 ◽  
Vol 30 (7) ◽  
pp. 1257-1258 ◽  
Author(s):  
P K Buamah ◽  
C Cornell ◽  
A W Skillen
Keyword(s):  
Germ Cell ◽  
Affinity Chromatography ◽  
Germ Cells ◽  
Concanavalin A ◽  
Primary Liver Cancer ◽  
Germ Cell Tumors ◽  
Alpha Fetoprotein ◽  
Hepatic Parenchyma ◽  
Liver Cancers ◽  
Serum Alpha Fetoprotein

Abstract We used affinity chromatography on concanavalin A Sepharose to study the serum alpha-fetoprotein of 10 patients with histologically proven germ-cell tumors and 12 patients with primary liver cancer. Less than 50% of the fetoprotein from germ-cell tumors bound to concanavalin A, as compared with more than 80% of the alpha-fetoprotein from primary liver cancers.

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