Hyperbaric Oxygen Therapy Ameliorates Local Brain Metabolism, Brain Edema and Inflammatory Response in a Blast-Induced Traumatic Brain Injury Model in Rabbits

2014 ◽  
Vol 39 (5) ◽  
pp. 950-960 ◽  
Author(s):  
Yongming Zhang ◽  
Yanyan Yang ◽  
Hong Tang ◽  
Wenjiang Sun ◽  
Xiaoxing Xiong ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Inflammatory Response ◽  
Brain Edema ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Brain Metabolism ◽  
Traumatic Brain Injury Model ◽  
Injury Model ◽  
Local Brain

Effect of Ultrasound Treatment on Brain Edema in a Traumatic Brain Injury Model with the Weight Drop Method

2012 ◽  
Vol 48 (2) ◽  
pp. 102-108 ◽  
Author(s):  
Soo Han Yoon ◽  
Soon Keun Kwon ◽  
So Ra Park ◽  
Byoung-Hyun Min
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Edema ◽  
Ultrasound Treatment ◽  
Drop Method ◽  
Traumatic Brain Injury Model ◽  
Injury Model ◽  
Weight Drop

Primary Explosive Blast-induced Traumatic Brain Injury Model in PC12 Cell Culture

BIO-PROTOCOL ◽  
2016 ◽  
Vol 6 (16) ◽  
Author(s):  
Thuvan Piehler ◽  
Nicole Zander ◽  
Richard Benjamin
Keyword(s):  
Traumatic Brain Injury ◽  
Cell Culture ◽  
Brain Injury ◽  
Pc12 Cell ◽  
Traumatic Brain Injury Model ◽  
Injury Model

scholarly journals Effect Sizes for Symptomatic and Cognitive Improvements in Traumatic Brain Injury Following Hyperbaric Oxygen Therapy

2021 ◽  
Author(s):  
Adam Thomas Biggs ◽  
Hugh M. Dainer ◽  
Lanny F Littlejohn
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Brain Injuries ◽  
Statistical Significance ◽  
Traumatic Brain Injuries ◽  
Therapeutic Benefit ◽  
Effect Sizes

Hyperbaric oxygen therapy has been proposed as a method to treat traumatic brain injuries. The combination of pressure and increased oxygen concentration produces a higher content of dissolved oxygen in the bloodstream, which could generate a therapeutic benefit for brain injuries. This dissolved oxygen penetrates deeper into damaged brain tissue than otherwise possible and promotes healing. The result includes improved cognitive functioning and an alleviation of symptoms. However, randomized controlled trials have failed to produce consistent conclusions across multiple studies. There are numerous explanations that might account for the mixed evidence, although one possibility is that prior evidence focuses primarily on statistical significance. The current analyses explored existing evidence by calculating an effect size from each active treatment group and each control group among previous studies. An effect size measure offers several advantages when comparing across studies as it can be used to directly contrast evidence from different scales, and it provides a proximal measure of clinical significance. When exploring the therapeutic benefit through effect sizes, there was a robust and consistent benefit to individuals who underwent hyperbaric oxygen therapy. Placebo effects from the control condition could account for approximately one-third of the observed benefits, but there appeared to be a clinically significant benefit to using hyperbaric oxygen therapy as a treatment intervention for traumatic brain injuries. This evidence highlights the need for design improvements when exploring interventions for traumatic brain injury as well as the importance of focusing on clinical significance in addition to statistical significance.

scholarly journals Probabilistic Matching of Deidentified Data From a Trauma Registry and a Traumatic Brain Injury Model System Center

2018 ◽  
Vol 97 (4) ◽  
pp. 236-241 ◽  
Author(s):  
Raj G. Kumar ◽  
Zhensheng Wang ◽  
Matthew R. Kesinger ◽  
Mark Newman ◽  
Toan T. Huynh ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Trauma Registry ◽  
Model System ◽  
Traumatic Brain Injury Model ◽  
Injury Model

scholarly journals Baicalin Protects Mice Brain From Apoptosis in Traumatic Brain Injury Model Through Activation of Autophagy

2019 ◽  
Vol 12 ◽  
Author(s):  
Jiang Fang ◽  
Yihao Zhu ◽  
Handong Wang ◽  
Bailu Cao ◽  
Maoxing Fei ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Traumatic Brain Injury Model ◽  
Injury Model ◽  
Mice Brain
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