Peroxisome Proliferator-Activated Receptor-Gamma (PPAR-ɣ): Molecular Effects and Its Importance as a Novel Therapeutic Target for Cerebral Ischemic Injury

2021 ◽  
Author(s):  
Ashi Mannan ◽  
Nikhil Garg ◽  
Thakur Gurjeet Singh ◽  
Harmeet Kaur Kang
Keyword(s):  
Therapeutic Target ◽  
Ischemic Injury ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Molecular Effects ◽  
Cerebral Ischemic Injury ◽  
Cerebral Ischemic ◽  
Novel Therapeutic

scholarly journals Peroxisome proliferator-activated receptor α as a novel therapeutic target for schizophrenia

EBioMedicine ◽  
2020 ◽  
Vol 62 ◽  
pp. 103130
Author(s):  
Yuina Wada ◽  
Motoko Maekawa ◽  
Tetsuo Ohnishi ◽  
Shabeesh Balan ◽  
Shigeru Matsuoka ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Novel Therapeutic

scholarly journals NOX5 as a therapeutic target in cerebral ischemic injury

2019 ◽  
Vol 129 (4) ◽  
pp. 1530-1532
Author(s):  
Luciana Simão do Carmo ◽  
Bradford C. Berk ◽  
David G. Harrison
Keyword(s):  
Therapeutic Target ◽  
Ischemic Injury ◽  
Cerebral Ischemic Injury ◽  
Cerebral Ischemic

Biochemical indices of cerebral ischemic injury

1983 ◽  
Vol 43 (3) ◽  
pp. 261-265 ◽  
Author(s):  
T. Bohmer ◽  
J. Kjekshus ◽  
P. Vaagenes
Keyword(s):  
Ischemic Injury ◽  
Cerebral Ischemic Injury ◽  
Cerebral Ischemic ◽  
Biochemical Indices

scholarly journals Intradialytic Cerebral Hypoperfusion as Mechanism for Cognitive Impairment in Patients on Hemodialysis

2019 ◽  
Vol 30 (11) ◽  
pp. 2052-2058 ◽  
Author(s):  
Dawn F. Wolfgram
Keyword(s):  
Cognitive Impairment ◽  
Cerebral Perfusion ◽  
Ischemic Injury ◽  
Hemodialysis Patients ◽  
Cognitive Outcomes ◽  
Cerebral Injury ◽  
Cerebral Hypoperfusion ◽  
Increased Risk ◽  
Cerebral Ischemic Injury ◽  
Cerebral Ischemic

The high frequency of cognitive impairment in individuals on hemodialysis is well characterized. In-center hemodialysis patients are disproportionately affected by cognitive impairment compared with other dialysis populations, identifying hemodialysis itself as a possible factor. The pathophysiology of cognitive impairment has multiple components, but vascular-mediated cerebral injury appears to contribute based on studies demonstrating increased cerebral ischemic lesions and atrophy in brain imaging of patients on hemodialysis. Patients on hemodialysis may be at increased risk for cerebral ischemic injury disease due to vasculopathy associated with ESKD and from their comorbid diseases, such as hypertension and diabetes. This review focuses on the intradialytic cerebral hypoperfusion that can occur during routine hemodialysis due to the circulatory stress of hemodialysis. This includes a review of current methods used to monitor intradialytic cerebral perfusion and the structural and functional cognitive outcomes that have been associated with changes in intradialytic cerebral perfusion. Monitoring of intradialytic cerebral perfusion may become clinically relevant as nephrologists try to avoid the cognitive complications seen with hemodialysis. Identifying the appropriate methods to assess risk for cerebral ischemic injury and the relationship of intradialytic cerebral hypoperfusion to cognitive outcomes will help inform the decision to use intradialytic cerebral perfusion monitoring in the clinical setting as part of a strategy to prevent cognitive decline.

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