TT2014 meeting report on the 12th Transgenic Technology meeting in Edinburgh: new era of transgenic technologies with programmable nucleases in the foreground

AbstractThe 16th transgenic technology (TT) meeting of the International Society of Transgenic technology (ISTT) took place on October 26–29th 2020 and was quite unique as it was the first-ever virtual meeting in the history of ISTT events. Dr. Rebecca Haffner-Krausz at Weizmann Institute of Science, Israel, was the local organizer of the meeting, which attracted 756 registered participants from 32 different countries.

Download Full-text

9th transgenic technology meeting (TT2010) in Berlin, Germany: a meeting report

Transgenic Research ◽

10.1007/s11248-010-9397-2 ◽

2010 ◽

Vol 19 (6) ◽

pp. 1145-1148

Author(s):

Thomas L. Saunders ◽

Peter Sobieszczuk

Keyword(s):

Meeting Report ◽

Transgenic Technology ◽

Transgenic Technology Meeting

Download Full-text

6th Transgenic Technology Meeting Report (http://www.cnb.uam.es/~tt2005)

Transgenic Research ◽

10.1007/s11248-005-5025-y ◽

2006 ◽

Vol 15 (2) ◽

pp. 267-269

Author(s):

Elizabeth Williams

Keyword(s):

Meeting Report ◽

Transgenic Technology ◽

Transgenic Technology Meeting

Download Full-text

Transgenic technologies for enhanced molecular breeding of white clover (Trifolium repens L.)

Crop and Pasture Science ◽

10.1071/cp12184 ◽

2013 ◽

Vol 64 (1) ◽

pp. 26 ◽

Cited By ~ 6

Author(s):

J. W. Forster ◽

S. Panter ◽

A. Mouradov ◽

J. Mason ◽

G. C. Spangenberg

Keyword(s):

White Clover ◽

Molecular Breeding ◽

Agronomic Traits ◽

Insect Pests ◽

Current Status ◽

Aluminium Tolerance ◽

Transgenic Technology ◽

Environmental Benefit ◽

Pasture Grass ◽

Transgenic Technologies

White clover is an important pasture legume of temperate regions, generally through co-cultivation with a pasture grass in a mixed-sward setting. White clover provides herbage with high nutritional quality to grazing animals, along with the environmental benefit of biological nitrogen fixation. Several key agronomic traits are amenable to modification in white clover through use of transgenic technology. Efficient methods for Agrobacterium-mediated transformation of white clover have been developed. The current status of transgenic research is reviewed for the following traits: resistance to viruses and insect pests; aluminium tolerance and phosphorus acquisition efficiency; control of leaf senescence and seed yield; biosynthesis of flavonoids and rumen bypass proteins for bloat safety and enhanced ruminant nutrition; cyanogenesis; and drought tolerance. Future prospects for transgenic technology in molecular breeding in white clover are also discussed.

Download Full-text

AMA Interim Meeting report: Sammons' retirement announced for 1991; AMA board, delegates prepare for a new era

JAMA ◽

10.1001/jama.262.24.3467 ◽

1989 ◽

Vol 262 (24) ◽

pp. 3467-3468

Author(s):

D. L. Breo

Keyword(s):

Meeting Report ◽

New Era

Download Full-text

Therapeutic genome editing with engineered nucleases

Hämostaseologie ◽

10.5482/hamo-16-09-0035 ◽

2017 ◽

Vol 37 (01) ◽

pp. 45-52 ◽

Cited By ~ 6

Author(s):

Simone Haas ◽

Viviane Dettmer ◽

Toni Cathomen

Keyword(s):

Gene Therapy ◽

Genome Editing ◽

Genetic Disorders ◽

Zinc Finger Nucleases ◽

New Era ◽

Engineered Nucleases ◽

Genetic Interventions ◽

Type Gene ◽

Programmable Nucleases ◽

Cancer Immunotherapies

SummaryTargeted genome editing with designer nucleases, such as zinc finger nucleases, TALE nucleases, and CRISPR-Cas nucleases, has heralded a new era in gene therapy. Genetic disorders, which have not been amenable to conventional gene-addition-type gene therapy approaches, such as disorders with dominant inheritance or diseases caused by mutations in tightly regulated genes, can now be treated by precise genome surgery. Moreover, engineered nucleases enable novel genetic interventions to fight infectious diseases or to improve cancer immunotherapies. Here, we review the development of the different classes of programmable nucleases, discuss the challenges and improvements in translating gene editing into clinical use, and give an outlook on what applications can expect to enter the clinic in the near future.

Download Full-text