scholarly journals Tetramethylpyrazine induces heme oxygenase-1 expression and attenuates myocardial ischemia/reperfusion injury in rats

2006 ◽  
Vol 13 (5) ◽  
pp. 731-740 ◽  
Author(s):  
Shu-Ying Chen ◽  
George Hsiao ◽  
Hwong-Ru Hwang ◽  
Pao-Yun Cheng ◽  
Yen-Mei Lee
Keyword(s):  
Myocardial Ischemia ◽  
Reperfusion Injury ◽  
Heme Oxygenase ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Heme Oxygenase 1 ◽  
Myocardial Ischemia Reperfusion Injury ◽  
Myocardial Ischemia Reperfusion

scholarly journals Inhibition of IL-1β secretion and mitochondria respiration by arsenite which acts on myocardial ischemia-reperfusion injury

2019 ◽  
Author(s):  
Min Li ◽  
Yingwu Mei ◽  
Jingeng Liu ◽  
Kaikai Fan ◽  
Xinyue Gu ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
In Vivo Model ◽  
Heme Oxygenase 1 ◽  
Biological Target ◽  
Myocardial Ischemia Reperfusion Injury ◽  
Myocardial Ischemia Reperfusion

ABSTRACTArsenite (NaAsO2) is a potent toxin that significantly contributes to human pathogenesis. Chronic exposure to arsenite results in various diseases. The physiologically important biological target(s) of arsenite exposure is largely unknown. Here we found that transient sodium arsenite treatment (1) blocks nigericin or Rotenone induced IL-1β secretion; (2) inhibits mitochondrial respiration with complex I–linked substrate; (3) induces Heme oxygenase-1 (HO-1) in myocardial tissue. (4) attenuates the myocardial ischemia-reperfusion injury in an in vivo model of rats. The causal relationship among these activities needs further investigation.

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