scholarly journals Regulation of intestinal stem cell fate specification

2015 ◽  
Vol 58 (6) ◽  
pp. 570-578 ◽  
Author(s):  
Zhen Qi ◽  
Ye-Guang Chen
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Intestinal Stem Cell ◽  
Cell Fate Specification ◽  
Stem Cell Fate ◽  
Fate Specification

Stem Cell Fate Specification: Role of Master Regulatory Switch Transcription Factor PU.1 in Differential Hematopoiesis

2005 ◽  
Vol 14 (2) ◽  
pp. 140-152 ◽  
Author(s):  
Gurudutta U. Gangenahalli ◽  
Pallavi Gupta ◽  
Daman Saluja ◽  
Yogesh K. Verma ◽  
Vimal Kishore ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Stem Cell ◽  
Cell Fate ◽  
Cell Fate Specification ◽  
Stem Cell Fate ◽  
Fate Specification

scholarly journals Stem cell fate in hypoxic root apical meristems is influenced by phytoglobin expression

2019 ◽  
Author(s):  
Mohammed M Mira ◽  
Eman A El-Khateeb ◽  
Reda M Gaafar ◽  
Abir U Igamberdiev ◽  
Robert D Hill ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Cell Fate Specification ◽  
Stem Cell Fate ◽  
Fate Specification ◽  
Apical Meristems ◽  
And Function

Overexpression of phytoglobin retains stem cell fate specification and function in hypoxic root apical meristems

scholarly journals MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling

Cell Reports ◽  
2021 ◽  
Vol 35 (7) ◽  
pp. 109124
Author(s):  
Hideyuki Nakashima ◽  
Keita Tsujimura ◽  
Koichiro Irie ◽  
Takuya Imamura ◽  
Cleber A. Trujillo ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Neural Stem Cell ◽  
Cell Fate Specification ◽  
Stem Cell Fate ◽  
Smad Signaling ◽  
Fate Specification

scholarly journals A complex of the ubiquitin ligase TRIM32 and the deubiquitinase USP7 balances the level of c-Myc ubiquitination and thereby determines neural stem cell fate specification

2018 ◽  
Vol 26 (4) ◽  
pp. 728-740 ◽  
Author(s):  
Sarah Nicklas ◽  
Anna-Lena Hillje ◽  
Satoshi Okawa ◽  
Ina-Maria Rudolph ◽  
Franziska Melanie Collmann ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Neural Stem Cell ◽  
Ubiquitin Ligase ◽  
Cell Fate Specification ◽  
Stem Cell Fate ◽  
Fate Specification

scholarly journals Intracellular pH dynamics regulates intestinal stem cell fate

2021 ◽  
Author(s):  
Diane L. Barber ◽  
Yi Liu ◽  
Efren Reyes ◽  
David Castillo-Azofeifa ◽  
Ophir D Klein ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Intracellular Ph ◽  
Paneth Cell ◽  
Cell Lineage ◽  
Adult Stem Cell ◽  
Intestinal Stem Cell ◽  
Cell Fate Specification ◽  
Stem Cell Fate ◽  
Stem Cell Lineage

Emerging evidence is revealing critical roles of intracellular pH (pHi) in development, but it remains unclear whether pHi regulates stem cell fate specification. We find that pHi dynamics is a key regulator of cell fate in the mouse intestinal stem cell lineage. We identify a pHi gradient along the intestinal crypt axis and find that dissipating this gradient inhibits crypt budding due to loss Paneth cell differentiation. Mechanistically, decreasing pHi biases intestinal stem cell fate toward the absorptive and away from the secretory lineage, by regulating the activity of the lineage transcription factor Atoh1. Our findings reveal a previously unrecognized role for pHi dynamics in the specification of cell fate within an adult stem cell lineage.

scholarly journals LKB1 Represses ATOH1 via PDK4 and Energy Metabolism and Regulates Intestinal Stem Cell Fate

2020 ◽  
Vol 158 (5) ◽  
pp. 1389-1401.e10 ◽  
Author(s):  
Yajing Gao ◽  
Yan Yan ◽  
Sushil Tripathi ◽  
Nalle Pentinmikko ◽  
Ana Amaral ◽  
...  
Keyword(s):  
Stem Cell ◽  
Energy Metabolism ◽  
Cell Fate ◽  
Intestinal Stem Cell ◽  
Stem Cell Fate

Regulation of Intestinal Stem Cell Fate

2014 ◽  
Vol 44 (10) ◽  
pp. 975-984
Author(s):  
YeGuang CHEN ◽  
Zhen QI
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Intestinal Stem Cell ◽  
Stem Cell Fate

scholarly journals Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate

Cell ◽  
2009 ◽  
Vol 136 (5) ◽  
pp. 903-912 ◽  
Author(s):  
Laurens G. van der Flier ◽  
Marielle E. van Gijn ◽  
Pantelis Hatzis ◽  
Pekka Kujala ◽  
Andrea Haegebarth ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Stem Cell ◽  
Cell Fate ◽  
Intestinal Stem Cell ◽  
Stem Cell Fate
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