scholarly journals Overexpression of Ran GTPase Components Regulating Nuclear Export, but not Mitotic Spindle Assembly, Marks Chromosome Instability and Poor Prognosis in Breast Cancer

2016 ◽  
Vol 11 (5) ◽  
pp. 677-686 ◽  
Author(s):  
Srividya Vaidyanathan ◽  
Pulari U. Thangavelu ◽  
Pascal H. G. Duijf
Keyword(s):  
Breast Cancer ◽  
Mitotic Spindle ◽  
Nuclear Export ◽  
Poor Prognosis ◽  
Chromosome Instability ◽  
Spindle Assembly ◽  
Ran Gtpase ◽  
Mitotic Spindle Assembly

scholarly journals Leishmania donovani Ran-GTPase interacts at the nuclear rim with linker histone H1

2009 ◽  
Vol 424 (3) ◽  
pp. 367-374 ◽  
Author(s):  
Despina Smirlis ◽  
Haralabia Boleti ◽  
Maria Gaitanou ◽  
Manuel Soto ◽  
Ketty Soteriadou
Keyword(s):  
Mitotic Spindle ◽  
Leishmania Donovani ◽  
Spindle Assembly ◽  
Histone H1 ◽  
Linker Histone ◽  
Core Histone ◽  
Ran Gtpase ◽  
Linker Histone H1 ◽  
Mitotic Spindle Assembly ◽  
Mammalian Counterpart

Ran-GTPase regulates multiple cellular processes such as nucleocytoplasmic transport, mitotic spindle assembly, nuclear envelope assembly, cell-cycle progression and the mitotic checkpoint. The leishmanial Ran protein, in contrast with its mammalian counterpart which is predominately nucleoplasmic, is localized at the nuclear rim. The aim of the present study was to characterize the LdRan (Leishmania donovani Ran) orthologue with an emphasis on the Ran–histone association. LdRan was found to be developmentally regulated, expressed 3-fold less in the amastigote stage. LdRan overexpression caused a growth defect linked to a delayed S-phase progression in promastigotes as for its mammalian counterpart. We report for the first time that Ran interacts with a linker histone, histone H1, in vitro and that the two proteins co-localize at the parasite nuclear rim. Interaction of Ran with core histones H3 and H4, creating in metazoans a chromosomal Ran-GTP gradient important for mitotic spindle assembly, is speculative in Leishmania spp., not only because this parasite undergoes a closed mitosis, but also because the main localization of LdRan is different from that of core histone H3. Interaction of Ran with the leishmanial linker histone H1 (LeishH1) suggests that this association maybe involved in modulation of pathways other than those documented for the metazoan Ran–core histone association.

scholarly journals The Ran GTPase regulates mitotic spindle assembly

1999 ◽  
Vol 9 (9) ◽  
pp. 481-484 ◽  
Author(s):  
Petr Kalab ◽  
Robert T. Pu ◽  
Mary Dasso
Keyword(s):  
Mitotic Spindle ◽  
Spindle Assembly ◽  
Ran Gtpase ◽  
Mitotic Spindle Assembly

scholarly journals PO-466 PI3K-C2A regulates mitotic spindle assembly and chemotherapy response in breast cancer

2018 ◽  
Author(s):  
M Martini ◽  
MC De Santis ◽  
F Gulluni ◽  
D Di Salvatore ◽  
F Montemurro ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mitotic Spindle ◽  
Spindle Assembly ◽  
Chemotherapy Response ◽  
Mitotic Spindle Assembly

scholarly journals Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function

Cancer Cell ◽  
2017 ◽  
Vol 32 (4) ◽  
pp. 444-459.e7 ◽  
Author(s):  
Federico Gulluni ◽  
Miriam Martini ◽  
Maria Chiara De Santis ◽  
Carlo Cosimo Campa ◽  
Alessandra Ghigo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mitotic Spindle ◽  
Genomic Stability ◽  
Spindle Assembly ◽  
Mitotic Spindle Assembly

scholarly journals Novel insights into the mechanisms of mitotic spindle assembly by NEK kinases

2016 ◽  
Vol 3 (3) ◽  
pp. e1062952 ◽  
Author(s):  
Suzanna L. Prosser ◽  
Laura O'Regan ◽  
Andrew M. Fry
Keyword(s):  
Mitotic Spindle ◽  
Spindle Assembly ◽  
Mitotic Spindle Assembly
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