Changes of high mobility group box 1 in serum of pig acute hepatic failure model and significance

2008 ◽  
Vol 28 (1) ◽  
pp. 52-55 ◽  
Author(s):  
Fan Zhang ◽  
Yongwen He ◽  
Zhongping Duan
Keyword(s):  
Hepatic Failure ◽  
High Mobility ◽  
Acute Hepatic Failure ◽  
High Mobility Group ◽  
Failure Model

793 An Increased Serum Level of High-Mobility Group Box 1 in the Pig Fulminant Hepatic Failure Model

2008 ◽  
Vol 134 (4) ◽  
pp. A-772
Author(s):  
Kiminori Takano ◽  
Masahiro Shinoda ◽  
Minoru Tanabe ◽  
Yasushi Fuchimoto ◽  
Taku Miyasho ◽  
...  
Keyword(s):  
Serum Level ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
High Mobility ◽  
High Mobility Group ◽  
Failure Model

929 GENE TRANSFER OF THE HIGH MOBILITY GROUP BOX 1 INHIBITOR IN RAT ACUTE LIVER FAILURE MODEL

2011 ◽  
Vol 54 ◽  
pp. S371-S372 ◽  
Author(s):  
M. Shinoda ◽  
M. Tanabe ◽  
A. Takayanagi ◽  
R. Nishiyama ◽  
G. Oshima ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
High Mobility ◽  
High Mobility Group ◽  
Failure Model

Gene transfer of high-mobility group box 1 box-A domain in a rat acute liver failure model

2015 ◽  
Vol 194 (2) ◽  
pp. 571-580 ◽  
Author(s):  
Masayuki Tanaka ◽  
Masahiro Shinoda ◽  
Atsushi Takayanagi ◽  
Go Oshima ◽  
Ryo Nishiyama ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
High Mobility ◽  
High Mobility Group ◽  
Failure Model

832 SERUM HIGH-MOBILITY GROUP BOX 1 LEVEL IN THE PATIENTS WITH FULMINANT HEPATIC FAILURE AND ITS BLOCKADE EFFECT IN RAT MODEL

2010 ◽  
Vol 52 ◽  
pp. S325
Author(s):  
G. Oshima ◽  
M. Shinoda ◽  
M. Tanabe ◽  
A. Takayanagi ◽  
T. Miyasho ◽  
...  
Keyword(s):  
Fulminant Hepatic Failure ◽  
Rat Model ◽  
Hepatic Failure ◽  
High Mobility ◽  
High Mobility Group

scholarly journals Effects of Lipo prostaglandin E1 in an experimentally-induced acute hepatic failure model.

Ensho ◽  
1990 ◽  
Vol 10 (2) ◽  
pp. 115-118
Author(s):  
Yasuhiro Mizoguchi ◽  
Hiroshi Kuboi ◽  
Norifumi Kawada ◽  
Kenzo Kobayashi ◽  
Seiji Morisawa
Keyword(s):  
Hepatic Failure ◽  
Prostaglandin E1 ◽  
Acute Hepatic Failure ◽  
Failure Model ◽  
Experimentally Induced

S1001 Anti-High Mobility Group Box Chromosomal Protein 1 Antibodies Improve Survival of Rats with Fulminant Hepatic Failure

2009 ◽  
Vol 136 (5) ◽  
pp. A-810
Author(s):  
Kiminori Takano ◽  
Masahiro Shinoda ◽  
Minoru Tanabe ◽  
Shigeshi Ono ◽  
Go Oshima ◽  
...  
Keyword(s):  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
High Mobility ◽  
High Mobility Group ◽  
Chromosomal Protein

Hemoadsorption of high-mobility-group box 1 using a porous polymethylmethacrylate fiber in a swine acute liver failure model

2018 ◽  
Vol 41 (4) ◽  
pp. 190-200
Author(s):  
Ryusuke Amemiya ◽  
Masahiro Shinoda ◽  
Masayuki Yamada ◽  
Yoshiyuki Ueno ◽  
Kaoru Shimada ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Adsorption Capacity ◽  
High Mobility ◽  
High Mobility Group ◽  
Chromosomal Protein ◽  
Failure Model ◽  
In Vitro Incubation ◽  
Control Column

Background: High-mobility-group box chromosomal protein 1 has been identified as an important mediator of various kinds of acute and chronic inflammation. In this study, we aimed to develop a column that effectively adsorbs high-mobility-group box chromosomal protein 1 by altering the pore size of the fiber. Materials and methods: First, we produced three types of porous polymethylmethacrylate fiber by altering the concentration of polymethylmethacrylate dissolved in dimethylsulfoxide. We then selected a fiber based on the results of an in vitro incubation test of high-mobility-group box chromosomal protein 1 adsorption. Using the selected fiber, we constructed a new column and tested its high-mobility-group box chromosomal protein 1 adsorption capacity during 4-h extracorporeal hemoperfusion in a swine acute liver failure model. Results: Electron microscope observation showed that the three types of fibers had different pore sizes on the surface and in cross section, which were dependent on the concentration of polymethylmethacrylate. In the in vitro incubation test, fiber with moderate-sized pores demonstrated the highest adsorption capacity. In the in vivo hemoperfusion study, the ratio of the high-mobility-group box chromosomal protein 1 concentration at the outlet versus the inlet of the column was significantly lower with the new column than with the control column during 4-h extracorporeal hemoperfusion. The normalized plasma level of high-mobility-group box chromosomal protein 1 at 12 h after the completion of hemoperfusion was significantly lower with the new column than with the control column. Conclusion: The newly developed polymethylmethacrylate column adsorbs high-mobility-group box chromosomal protein 1 during hemoperfusion in swine ALF model.

An experimentally-induced acute hepatic failure model in various strains of mice

1989 ◽  
Vol 24 (5) ◽  
pp. 519-522 ◽  
Author(s):  
Yasuhiro Mizoguchi ◽  
Hiroshi Kuboi ◽  
Hiroko Tsutsui ◽  
Shuichi Seki ◽  
Kenzo Kobayashi ◽  
...  
Keyword(s):  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Failure Model ◽  
Experimentally Induced

scholarly journals Effect of Secreted Molecules of Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells on Acute Hepatic Failure Model

2016 ◽  
Vol 25 (24) ◽  
pp. 1898-1908 ◽  
Author(s):  
Majid Lotfinia ◽  
Mehdi Kadivar ◽  
Abbas Piryaei ◽  
Behshad Pournasr ◽  
Soroush Sardari ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Hepatic Failure ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Acute Hepatic Failure ◽  
Failure Model

scholarly journals Evaluation of Effectiveness of Glucocorticoid Treatment using a Rat Acute Hepatic Failure Model.

Kanzo ◽  
1999 ◽  
Vol 40 (4) ◽  
pp. 217-226 ◽  
Author(s):  
Akihiro SATO ◽  
Yasuhiro TAKIKAWA ◽  
Shinichiro SATO ◽  
Kazuyuki SUZUKI
Keyword(s):  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Failure Model ◽  
Glucocorticoid Treatment
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