Externalized Stents for Pancreatoduodenectomy Provide Value Only in High-Risk Scenarios

2016 ◽  
Vol 20 (12) ◽  
pp. 2052-2062 ◽  
Author(s):  
Matthew T. McMillan ◽  
Brett L. Ecker ◽  
Stephen W. Behrman ◽  
Mark P. Callery ◽  
John D. Christein ◽  
...  
Keyword(s):  
High Risk ◽  
Risk Scenarios

High-Risk Scenarios and Future Trends

2009 ◽  
pp. 301-339
Author(s):  
Ophir Falk ◽  
Ofer Israeli ◽  
Shmuel C. Shapira
Keyword(s):  
High Risk ◽  
Future Trends ◽  
Risk Scenarios

Exposure to chemical mixtures in Mexican children: high-risk scenarios

2012 ◽  
Vol 20 (1) ◽  
pp. 351-357 ◽  
Author(s):  
Gabriela Domínguez-Cortinas ◽  
Fernando Díaz-Barriga ◽  
Rebeca Isabel Martínez-Salinas ◽  
Patricia Cossío ◽  
Iván Nelinho Pérez-Maldonado
Keyword(s):  
High Risk ◽  
Chemical Mixtures ◽  
Risk Scenarios ◽  
Mexican Children

scholarly journals External stents for pancreatoduodenectomy provide value only in high risk scenarios

HPB ◽  
2016 ◽  
Vol 18 ◽  
pp. e110-e111
Author(s):  
M. McMillan ◽  
S. Behrman ◽  
M. Callery ◽  
J. Christein ◽  
J. Drebin ◽  
...  
Keyword(s):  
High Risk ◽  
Risk Scenarios

High Risk Scenarios and Extremes

10.4171/035 ◽  
2007 ◽  
Author(s):  
Guus Balkema ◽  
Paul Embrechts
Keyword(s):  
High Risk ◽  
Risk Scenarios

scholarly journals Public support for healthcare-mediated disclosure of hereditary cancer risk information: Results from a population-based survey in Sweden

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Andreas Andersson ◽  
Carolina Hawranek ◽  
Anna Öfverholm ◽  
Hans Ehrencrona ◽  
Kalle Grill ◽  
...  
Keyword(s):  
At Risk ◽  
High Risk ◽  
Cancer Risk ◽  
Hereditary Cancer ◽  
Healthcare Professionals ◽  
Risk Information ◽  
Lifetime Risk ◽  
Targeted Prevention ◽  
Hereditary Risk ◽  
Risk Scenarios

Abstract Background Targeted surveillance of at-risk individuals in families with increased risk of hereditary cancer is an effective prevention strategy if relatives are identified, informed and enrolled in screening programs. Despite the potential benefits, many eligible at-risk relatives remain uninformed of their cancer risk. This study describes the general public’s opinion on disclosure of hereditary colorectal cancer (CRC) risk information, as well as preferences on the source and the mode of information. Methods A random sample of the general public was assessed through a Swedish citizen web-panel. Respondents were presented with scenarios of being an at-risk relative in a family that had an estimated increased hereditary risk of CRC; either 10% (moderate) or 70% (high) lifetime risk. A colonoscopy was presented as a preventive measure. Results were analysed to identify significant differences between groups using the Pearson’s chi-square (χ2) test. Results Of 1800 invited participants, 977 completed the survey (54%). In the moderate and high-risk scenarios, 89.2 and 90.6% respectively, would like to receive information about a potential hereditary risk of CRC (χ2, p = .755). The desire to be informed was higher among women (91.5%) than men (87.0%, χ2, p = .044). No significant differences were found when comparing different age groups, educational levels, place of residence and having children or not. The preferred source of risk information was a healthcare professional in both moderate and high-risk scenarios (80.1 and 75.5%). However, 18.1 and 20.1% respectively would prefer to be informed by a family member. Assuming that healthcare professionals disclosed the information, the favoured mode of information was letter and phone (38.4 and 33.2%). Conclusions In this study a majority of respondents wanted to be informed about a potential hereditary risk of CRC and preferred healthcare professionals to communicate this information. The two presented levels of CRC lifetime risk did not significantly affect the interest in being informed. Our data offer insights into the needs and preferences of the Swedish population, providing a rationale for developing complementary healthcare-assisted communication pathways to realise the full potential of targeted prevention of hereditary CRC.

A mixed-methods examination of the nature and frequency of medical error among junior doctors

2019 ◽  
Vol 95 (1129) ◽  
pp. 583-589
Author(s):  
Paul O'Connor ◽  
Sinéad Lydon ◽  
Orla Mongan ◽  
Fergal Connolly ◽  
Aoibheann Mcloughlin ◽  
...  
Keyword(s):  
Mixed Methods ◽  
High Risk ◽  
Medical Error ◽  
Critical Incident ◽  
Situational Factors ◽  
Contributory Factor ◽  
Junior Doctors ◽  
Risk Scenarios ◽  
High Workload ◽  
Medium Risk

Purpose of the studyTo examine junior doctors’ experience and perceptions of medical errors in which they had been involved.Study designA mixed-methods design, consisting of an error survey and critical incident technique (CIT) interviews, was used. The survey asked doctors in the first year of postgraduate training in Ireland whether they had made a medical error that had ‘played on (their) mind’, and if so, to identify factors that had contributed to the error. The participants in the CIT interviews were asked to describe a medical error in which they had been involved.ResultsA total of 201 out of 332 (60.5%) respondents to the survey reported making an error that ‘played on their mind’. 'Individual factors’ were the most commonly identified group of factors (188/201; 93.5%), with ‘high workload’ (145/201; 72.1%) the most commonly identified contributory factor. Of the 28 CIT interviews which met the criteria for analysis, ‘situational factors’ (team, staff, task characteristics, and service user factors) were the most commonly identified group of contributory factors (24/28; 85.7%). A total of eight of the interviews were judged by subject matter experts (n=8) to be of medium risk to patients, and 20 to be of high-risk to patients. A significantly larger proportion of high-risk scenarios were attributed to ‘local working conditions’ than the medium-risk scenarios.ConclusionsThere is a need to prepare junior doctors to manage, and cope with, medical error and to ensure that healthcare professionals are adequately supported throughout their careers.

scholarly journals Loss of SATB2 Occurs More Frequently Than CDX2 Loss in Colorectal Carcinoma and Identifies Particularly Aggressive Cancers in High-Risk Subgroups

Cancers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 6177
Author(s):  
Maxime Schmitt ◽  
Miguel Silva ◽  
Björn Konukiewitz ◽  
Corinna Lang ◽  
Katja Steiger ◽  
...  
Keyword(s):  
High Risk ◽  
Colorectal Carcinoma ◽  
Multivariate Analyses ◽  
Stage Iii ◽  
Uicc Stage ◽  
Prognostic Relevance ◽  
Risk Scenarios ◽  
Cdx2 Expression ◽  
Univariate Analyses ◽  
Sensitive Marker

Background: Special AT-rich sequence-binding protein 2 (SATB2) has emerged as an alternative immunohistochemical marker to CDX2 for colorectal differentiation. However, the distribution and prognostic relevance of SATB2 expression in colorectal carcinoma (CRC) have to be further elucidated. Methods: SATB2 expression was analysed in 1039 CRCs and correlated with clinicopathological and morphological factors, CDX2 expression as well as survival parameters within the overall cohort and in clinicopathological subgroups. Results: SATB2 loss was a strong prognosticator in univariate analyses of the overall cohort (p < 0.001 for all survival comparisons) and in numerous subcohorts including high-risk scenarios (UICC stage III/high tumour budding). SATB2 retained its prognostic relevance in multivariate analyses of these high-risk scenarios (e.g., UICC stage III: DSS: p = 0.007, HR: 1.95), but not in the overall cohort (DSS: p = 0.1, HR: 1.25). SATB2 loss was more frequent than CDX2 loss (22.2% vs. 10.2%, p < 0.001) and of higher prognostic relevance with only moderate overlap between SATB2/CDX2 expression groups. Conclusions: SATB2 loss is able to identify especially aggressive CRCs in high-risk subgroups. While SATB2 is the prognostically superior immunohistochemical parameter compared to CDX2 in univariate analyses, it appears to be the less sensitive marker for colorectal differentiation as it is lost more frequently.

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