Therapeutic Effect of Chang’an I Recipe (肠安 I 号方) on Irritable Bowel Syndrome with Diarrhea: A Multicenter Randomized Double-Blind Placebo-Controlled Clinical Trial

2016 ◽  
Vol 24 (9) ◽  
pp. 645-652 ◽  
Author(s):  
Xu-dong Tang ◽  
Bin Lu ◽  
Zhen-hua Li ◽  
Wei Wei ◽  
Li-na Meng ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Irritable Bowel Syndrome ◽  
Therapeutic Effect ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Irritable Bowel

scholarly journals Treatment of Irritable Bowel Syndrome with Saccharomyces Cerevisiae: علاج القولون العصبي باستخدام خميرة البيرة

2019 ◽  
Vol 3 (3) ◽  
Author(s):  
Amjad Atef Suliman Al-helo
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Clinical Trial ◽  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Bowel Movement ◽  
Gastrointestinal Symptoms ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Irritable Bowel

Aim: To evaluate the effect of probiotic Saccharomyces Cerevisiae in the treatment of Irritable Bowel Syndrome in a randomized, double-blind placebo-controlled clinical trial. Methods: A randomized, double-blind placebo-controlled clinical trial has been performed in 347 adults, diagnosed with IBS (Rome III criteria). Subjects were randomized to receive 1000 mg BID of Saccharomyces Cerevisiae daily for four-week, product 177, placebo 170. IBS symptoms (abdominal pain/discomfort, bloating/distension, bowel movement difficulty) and changes in stool frequency and consistency were recorded daily by the patients and assessed weekly by the investigator. Result: Improvement of Gastrointestinal symptoms was significantly higher in the product group, compared to the placebo, on (abdominal pain/discomfort, bloating/distension, bowel movement difficulty, with stool modification), p-value < 0.001 in the treated group, and the ratio between groups (130 vs. 47), (73.4% vs. 27.64%). Conclusion: Saccharomyces Cerevisiae significantly improves irritable bowel syndrome symptoms and is well tolerated  

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