Grape skin polyphenols (GSPs) inhibit the migration of mouse mammary carcinoma 4T1 cells in Vitro

2011 ◽  
Vol 8 (1) ◽  
Author(s):  
Qiu-yu Chen ◽  
Zhi-qiang Liang ◽  
Tao Sun ◽  
Xiang-jun Sun
Keyword(s):  
Mammary Carcinoma ◽  
Grape Skin ◽  
Mouse Mammary Carcinoma ◽  
4T1 Cells

Growth inhibitory effect of Scrophularia oxysepala extract on mouse mammary carcinoma 4T1 cells in vitro and in vivo systems

2017 ◽  
Vol 85 ◽  
pp. 718-724 ◽  
Author(s):  
Pooneh Chokhachi Baradaran ◽  
Ali Mohammadi ◽  
Behzad Mansoori ◽  
Sepideh Chokhachi Baradaran ◽  
Behzad Baradaran
Keyword(s):  
Mammary Carcinoma ◽  
Inhibitory Effect ◽  
Growth Inhibitory Effect ◽  
Mouse Mammary Carcinoma ◽  
Growth Inhibitory ◽  
4T1 Cells

Boldine Inhibits Mouse Mammary Carcinoma In Vivo and Human MCF-7 Breast Cancer Cells In Vitro

Planta Medica ◽  
2016 ◽  
Vol 82 (16) ◽  
pp. 1416-1424 ◽  
Author(s):  
Pavel Tomšík ◽  
Stanislav Mičuda ◽  
Darina Muthná ◽  
Eva Čermáková ◽  
Radim Havelek ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Mammary Carcinoma ◽  
Breast Cancer Cells ◽  
Mouse Mammary Carcinoma ◽  
Mcf 7

scholarly journals LyeTx I-b Peptide Attenuates Tumor Burden and Metastasis in a Mouse 4T1 Breast Cancer Model

Antibiotics ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1136
Author(s):  
Mostafa Abdel-Salam ◽  
Bárbara Pinto ◽  
Geovanni Cassali ◽  
Lilian Bueno ◽  
Gabriela Pêgas ◽  
...  
Keyword(s):  
Mammary Carcinoma ◽  
Tumor Burden ◽  
Primary Tumors ◽  
Mouse Mammary Carcinoma ◽  
Anticancer Peptides ◽  
Cell Proliferation Inhibition ◽  
Palpable Tumor ◽  
4T1 Breast Cancer

Cationic anticancer peptides have exhibited potent anti-proliferative and anti-inflammatory effects in neoplastic illness conditions. LyeTx I-b is a synthetic peptide derived from Lycosa erythrognatha spider venom that previously showed antibiotic activity in vitro and in vivo. This study focused on the effects of LyeTxI-b on a 4T1 mouse mammary carcinoma model. Mice with a palpable tumor in the left flank were subcutaneously or intratumorally injected with LyeTx I-b (5 mg/kg), which significantly decreased the tumor volume and metastatic nodules. Histological analyses showed a large necrotic area in treated primary tumors compared to the control. LyeTxI-b reduced tumor growth and lung metastasis in the 4T1 mouse mammary carcinoma model with no signs of toxicity in healthy or cancerous mice. The mechanism of action of LyeTx I-b on the 4T1 mouse mammary carcinoma model was evaluated in vitro and is associated with induction of apoptosis and cell proliferation inhibition. Furthermore, LyeTx I-b seems to be an efficient regulator of the 4T1 tumor microenvironment by modulating several cytokines, such as TGF-β, TNF-α, IL-1β, IL-6, and IL-10, in primary tumor and lung, spleen, and brain. LyeTx I-b also plays a role in leukocytes rolling and adhesion into spinal cord microcirculation and in the number of circulating leukocytes. These data suggest a potent antineoplastic efficacy ofLyeTx I-b.

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