Intraoperative Targeted Temperature Management in Acute Brain and Spinal Cord Injury

Author(s):  
Jacqueline Kraft ◽  
Anna Karpenko ◽  
Fred Rincon
Neurotrauma ◽  
2018 ◽  
pp. 447-460
Author(s):  
W. Dalton Dietrich ◽  
Helen M. Bramlett

Traumatic brain and spinal cord injury are devastating conditions that affect thousands of people each year within the United States. Despite significant research efforts, few successful treatments are available, reflecting the highly complex pathophysiology of neurotrauma. Treatment modalities that target multiple injury pathways may be required to provide robust and long-term improvements in functional recovery. The successful use of therapeutic hypothermia in various patient populations has a rich history, either applied selectively to the nervous tissues or administered systemically. Some recent clinical trials in brain and spinal cord injury have reported benefits with therapeutic hypothermia and targeted temperature management, whereas others have not shown dramatic improvements. This field remains controversial in terms of how and when to use temperature-related therapeutic interventions to maximize protection and repair. This chapter summarizes current knowledge on this evolving field and discusses future directions for research and clinical care.


2018 ◽  
Vol 106 (6) ◽  
pp. 1797-1803
Author(s):  
Nicolas Mongardon ◽  
Matthias Kohlhauer ◽  
Fanny Lidouren ◽  
Mariana Barretto ◽  
Philippe Micheau ◽  
...  

2021 ◽  
pp. 102692
Author(s):  
Lijian Zhang ◽  
Francisco R. López-Picón ◽  
Yingqin Jia ◽  
Yao Chen ◽  
Juan Li ◽  
...  

2018 ◽  
Vol 21 (3) ◽  
pp. 125-136 ◽  
Author(s):  
Raj Putatunda ◽  
John R. Bethea ◽  
Wen-Hui Hu

2020 ◽  
Author(s):  
Geoffrey S.F. Ling ◽  
Mohit Datta

Traumatic brain and spinal cord injuries are significant causes of permanent disability and death. In 2010, 823,000 traumatic brain injuries were reported in the United States alone; in fact, the actual number is likely considerably higher because mild traumatic brain injuries and concussions are underreported. The number of new traumatic spinal cord injuries has been estimated at 12,000 annually. Survival from these injuries has increased due to improvements in medical care. This review covers mild traumatic brain injury and concussion, moderate to severe traumatic brain injury, and traumatic spinal cord injury. Figures include computed tomography scans showing a frontal contusion, diffuse cerebral edema and intracranial air from a gunshot wound, a subdural hematoma, an epidural hematoma, a skull fracture with epidural hematoma, and a spinal fracture from a gunshot wound. Tables list requirements for players with concussion, key guidelines for prehospital management of moderate to severe traumatic brain injury, key guidelines for management of moderate to severe traumatic brain injury, brain herniation brain code, key clinical practice guidelines for managing cervical spine and spinal cord injury, and the American Spinal Injury Association’s neurologic classification of spinal cord injury. This review contains 6 highly rendered figures, 12 tables, and 55 references.


1998 ◽  
Vol 4 (2) ◽  
pp. 71-76 ◽  
Author(s):  
Phillip G. Popovich ◽  
Caroline C. Whitacre ◽  
Bradford T. Stokes

Cross-talk between cells of the nervous and immune systems is an emerging concept in neurotrauma research. Previously, neuroimmunological approaches in brain and spinal cord injury have focused on the functional consequences of macrophage and microglial activation. These cells constitute the natural, or innate, branch of CNS immunity and respond to injury or infection in a nonspecific fashion. Recent evidence, however, has shown that T-lymphocytes may also play a significant role in spinal cord injury. Once activated, T- and B-lymphocytes orchestrate the complex functions of the inflammatory response. Acquired immunity is readily induced against “non-self,” or foreign, antigens, although “self-reactive” lymphocytes are present in normal individuals, providing the potential for the onset of autoimmunity. Trauma to or infection in the CNS may release “self” antigens normally sequestered behind the blood-brain barrier that can trigger lymphocyte activation. This article addresses the potential pathological and physiological implications of lymphocyte activation induced by traumatic spinal cord injury. NEUROSCIENTIST 4:71-76, 1998


2009 ◽  
Vol 26 (3) ◽  
pp. 301-312 ◽  
Author(s):  
W. Dalton Dietrich ◽  
Coleen M. Atkins ◽  
Helen M. Bramlett

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