Therapeutic Hypothermia and Targeted Temperature Management in the Treatment of Traumatic Brain and Spinal Cord Injury

Neurotrauma ◽  
2018 ◽  
pp. 447-460
Author(s):  
W. Dalton Dietrich ◽  
Helen M. Bramlett
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Therapeutic Hypothermia ◽  
Clinical Care ◽  
Targeted Temperature Management ◽  
Temperature Management ◽  
Treatment Modalities ◽  
Cord Injury ◽  
Significant Research ◽  
Brain And Spinal Cord

Traumatic brain and spinal cord injury are devastating conditions that affect thousands of people each year within the United States. Despite significant research efforts, few successful treatments are available, reflecting the highly complex pathophysiology of neurotrauma. Treatment modalities that target multiple injury pathways may be required to provide robust and long-term improvements in functional recovery. The successful use of therapeutic hypothermia in various patient populations has a rich history, either applied selectively to the nervous tissues or administered systemically. Some recent clinical trials in brain and spinal cord injury have reported benefits with therapeutic hypothermia and targeted temperature management, whereas others have not shown dramatic improvements. This field remains controversial in terms of how and when to use temperature-related therapeutic interventions to maximize protection and repair. This chapter summarizes current knowledge on this evolving field and discusses future directions for research and clinical care.

scholarly journals Targeted Temperature Management With Total Liquid Ventilation After Ischemic Spinal Cord Injury

2018 ◽  
Vol 106 (6) ◽  
pp. 1797-1803
Author(s):  
Nicolas Mongardon ◽  
Matthias Kohlhauer ◽  
Fanny Lidouren ◽  
Mariana Barretto ◽  
Philippe Micheau ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Targeted Temperature Management ◽  
Temperature Management ◽  
Liquid Ventilation ◽  
Cord Injury ◽  
Ischemic Spinal Cord Injury

scholarly journals Longitudinal [18F]FDG and [13N]NH3 PET/CT imaging of brain and spinal cord in a canine hemisection spinal cord injury model

2021 ◽  
pp. 102692
Author(s):  
Lijian Zhang ◽  
Francisco R. López-Picón ◽  
Yingqin Jia ◽  
Yao Chen ◽  
Juan Li ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Ct Imaging ◽  
Spinal Cord Injury Model ◽  
Injury Model ◽  
Pet Ct ◽  
Cord Injury ◽  
18F Fdg ◽  
Brain And Spinal Cord

scholarly journals Potential immunotherapies for traumatic brain and spinal cord injury

2018 ◽  
Vol 21 (3) ◽  
pp. 125-136 ◽  
Author(s):  
Raj Putatunda ◽  
John R. Bethea ◽  
Wen-Hui Hu
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cord Injury ◽  
Brain And Spinal Cord

Traumatic Brain and Spinal Cord Injuries

2020 ◽  
Author(s):  
Geoffrey S.F. Ling ◽  
Mohit Datta
Keyword(s):  
Traumatic Brain Injury ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Brain Injury ◽  
Severe Traumatic Brain Injury ◽  
Gunshot Wound ◽  
Brain Injuries ◽  
Spinal Cord Injuries ◽  
Cord Injury ◽  
Brain And Spinal Cord

Traumatic brain and spinal cord injuries are significant causes of permanent disability and death. In 2010, 823,000 traumatic brain injuries were reported in the United States alone; in fact, the actual number is likely considerably higher because mild traumatic brain injuries and concussions are underreported. The number of new traumatic spinal cord injuries has been estimated at 12,000 annually. Survival from these injuries has increased due to improvements in medical care. This review covers mild traumatic brain injury and concussion, moderate to severe traumatic brain injury, and traumatic spinal cord injury. Figures include computed tomography scans showing a frontal contusion, diffuse cerebral edema and intracranial air from a gunshot wound, a subdural hematoma, an epidural hematoma, a skull fracture with epidural hematoma, and a spinal fracture from a gunshot wound. Tables list requirements for players with concussion, key guidelines for prehospital management of moderate to severe traumatic brain injury, key guidelines for management of moderate to severe traumatic brain injury, brain herniation brain code, key clinical practice guidelines for managing cervical spine and spinal cord injury, and the American Spinal Injury Association’s neurologic classification of spinal cord injury. This review contains 6 highly rendered figures, 12 tables, and 55 references.

scholarly journals Neuropathic Pain Related with Spinal Disorders: A Systematic Review

2017 ◽  
Vol 11 (4) ◽  
pp. 661-674 ◽  
Author(s):  
Kwang-Sup Song ◽  
Jae Hwan Cho ◽  
Jae-Young Hong ◽  
Jae Hyup Lee ◽  
Hyun Kang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuropathic Pain ◽  
Disc Herniation ◽  
Treatment Guidelines ◽  
Epidural Block ◽  
Treatment Modalities ◽  
High Quality ◽  
Spinal Disorders ◽  
Cord Injury

<p>Systematic literature review. To review the evidence from high-quality studies regarding the treatment of neuropathic pain originating specifically from spinal disorders. In general, treatment guidelines for neuropathic pain cover all its various causes, including medical disease, peripheral neuropathy, and cancer. However, the natural history of neuropathic pain originating from spinal disorders may differ from that of the pain originating from other causes or lesions. An expert research librarian used terms related to neuropathic pain and spinal disorders, disc herniation, stenosis, and spinal cord injury to search in MEDLINE, Embase, and Cochrane CENTRAL for primary research from January 2000 to October 2015. Among 2,313 potential studies of interest, 25 randomized controlled trials (RCTs) and 21 systematic reviews (SRs) were included in the analysis. The selection was decided based on the agreement of two orthopedic surgeons. There was a lack of evidence about medication for radiculopathy arising from disc herniation and stenosis, but intervention procedures, including epidural block, showed positive efficacy in radiculopathy and also limited efficacy in spinal stenosis. There was some evidence based on the short-term follow-up regarding surgery being superior to conservative treatments for radiculopathy and stenosis. There was limited evidence regarding the efficacy of pharmacological and electric or magnetic stimulation therapies for neuropathic pain after spinal cord injury. This review of RCTs and SRs with high-quality evidence found some evidence regarding the efficacy of various treatment modalities for neuropathic pain related specifically to spinal disorders. However, there is a need for much more supportive evidence.</p>

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