Subtractive Genomics Approach to Identify Putative Drug Targets and Identification of Drug-like Molecules for Beta Subunit of DNA Polymerase III in Streptococcus Species

Applied Biochemistry and Biotechnology ◽

10.1007/s12010-012-9620-0 ◽

2012 ◽

Vol 167 (5) ◽

pp. 1377-1395 ◽

Author(s):

John J. Georrge ◽

V. V. Umrania

Keyword(s):

Dna Polymerase ◽

Drug Targets ◽

Beta Subunit ◽

Dna Polymerase Iii ◽

Streptococcus Species ◽

Subtractive Genomics ◽

Polymerase Iii ◽

Subtractive Genomics Approach

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The beta subunit of the Escherichia coli DNA polymerase III holoenzyme interacts functionally with the catalytic core in the absence of other subunits.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)38427-2 ◽

1986 ◽

Vol 261 (16) ◽

pp. 7550-7557 ◽

Author(s):

R J LaDuca ◽

J J Crute ◽

C S McHenry ◽

R A Bambara

Keyword(s):

Escherichia Coli ◽

Dna Polymerase ◽

Beta Subunit ◽

Dna Polymerase Iii ◽

Catalytic Core ◽

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Excess beta subunit can bypass the ATP requirement for highly processive synthesis by the Escherichia coli DNA polymerase III holoenzyme.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)44423-1 ◽

1983 ◽

Vol 258 (18) ◽

pp. 11344-11349 ◽

Author(s):

J J Crute ◽

R J LaDuca ◽

K O Johanson ◽

C S McHenry ◽

R A Bambara

Keyword(s):

Escherichia Coli ◽

Dna Polymerase ◽

Beta Subunit ◽

Dna Polymerase Iii ◽

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The dnaN gene codes for the beta subunit of DNA polymerase III holoenzyme of escherichia coli.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.78.9.5391 ◽

1981 ◽

Vol 78 (9) ◽

pp. 5391-5395 ◽

Author(s):

P. M. Burgers ◽

A. Kornberg ◽

Y. Sakakibara

Keyword(s):

Escherichia Coli ◽

Dna Polymerase ◽

Beta Subunit ◽

Dna Polymerase Iii ◽

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The beta subunit of the DNA polymerase III holoenzyme becomes inaccessible to antibody after formation of an initiation complex with primed DNA.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)33715-3 ◽

1982 ◽

Vol 257 (20) ◽

pp. 12310-12315 ◽

Author(s):

K O Johanson ◽

C S McHenry

Keyword(s):

Dna Polymerase ◽

Beta Subunit ◽

Dna Polymerase Iii ◽

Initiation Complex ◽

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Chemical characterization and purification of the beta subunit of the DNA polymerase III holoenzyme from an overproducing strain.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)67266-7 ◽

1986 ◽

Vol 261 (25) ◽

pp. 11460-11465 ◽

Author(s):

K O Johanson ◽

T E Haynes ◽

C S McHenry

Keyword(s):

Dna Polymerase ◽

Chemical Characterization ◽

Beta Subunit ◽

Dna Polymerase Iii ◽

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Overproduction of the beta subunit of DNA polymerase III holoenzyme reduces UV mutagenesis in Escherichia coli.

Journal of Bacteriology ◽

10.1128/jb.174.8.2517-2524.1992 ◽

1992 ◽

Vol 174 (8) ◽

pp. 2517-2524 ◽

Author(s):

Y Tadmor ◽

R Ascarelli-Goell ◽

R Skaliter ◽

Z Livneh

Keyword(s):

Escherichia Coli ◽

Dna Polymerase ◽

Beta Subunit ◽

Dna Polymerase Iii ◽

Uv Mutagenesis ◽

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The beta subunit dissociates readily from the Escherichia coli DNA polymerase III holoenzyme.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)75698-1 ◽

1987 ◽

Vol 262 (4) ◽

pp. 1720-1724

Author(s):

R S Lasken ◽

A Kornberg

Keyword(s):

Escherichia Coli ◽

Dna Polymerase ◽

Beta Subunit ◽

Dna Polymerase Iii ◽

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Fluorescence energy transfer between the primer and the beta subunit of the DNA polymerase III holoenzyme.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)50693-7 ◽

1992 ◽

Vol 267 (5) ◽

pp. 3052-3059

Author(s):

M.A. Griep ◽

C.S. McHenry

Keyword(s):

Energy Transfer ◽

Dna Polymerase ◽

Beta Subunit ◽

Fluorescence Energy Transfer ◽

Dna Polymerase Iii ◽

Polymerase Iii ◽

Fluorescence Energy

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Dimer of the .beta. subunit of Escherichia coli DNA polymerase III holoenzyme is dissociated into monomers upon binding magnesium(II)

Biochemistry ◽

10.1021/bi00414a040 ◽

1988 ◽

Vol 27 (14) ◽

pp. 5210-5215 ◽

Author(s):

Mark A. Griep ◽

Charles S. McHenry

Keyword(s):

Escherichia Coli ◽

Dna Polymerase ◽

Beta Subunit ◽

Dna Polymerase Iii ◽

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Purification and characterization of the beta subunit of the DNA polymerase III holoenzyme of Escherichia coli.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)70404-9 ◽

1980 ◽

Vol 255 (22) ◽

pp. 10984-10990 ◽

Author(s):

K.O. Johanson ◽

C.S. McHenry

Keyword(s):

Escherichia Coli ◽

Dna Polymerase ◽

Beta Subunit ◽

Dna Polymerase Iii ◽

Purification And Characterization ◽

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