Effect of Lead Ion on the Function of the Human Ether-À-Go-Go-Related Gene K+ Channel

2010 ◽  
Vol 143 (1) ◽  
pp. 131-142 ◽  
Author(s):  
Jiemin Zhou ◽  
Gang Hu
Keyword(s):  
Lead Ion ◽  
K Channel ◽  
Related Gene

Discovery of a Small Molecule Activator of the Human Ether-a-go-go-Related Gene (HERG) Cardiac K+ Channel

2004 ◽  
Vol 67 (3) ◽  
pp. 827-836 ◽  
Author(s):  
Jiesheng Kang ◽  
Xiao-Liang Chen ◽  
Hongge Wang ◽  
Junzhi Ji ◽  
Hsien Cheng ◽  
...  
Keyword(s):  
Small Molecule ◽  
K Channel ◽  
Related Gene

scholarly journals Mechanistic Insight into Humanether-à-go-go-related Gene (hERG) K+Channel Deactivation Gating from the Solution Structure of the EAG Domain

2010 ◽  
Vol 286 (8) ◽  
pp. 6184-6191 ◽  
Author(s):  
Frederick W. Muskett ◽  
Samrat Thouta ◽  
Steven J. Thomson ◽  
Alexander Bowen ◽  
Phillip J. Stansfeld ◽  
...  
Keyword(s):  
Solution Structure ◽  
K Channel ◽  
Related Gene ◽  
Mechanistic Insight ◽  
Insight Into

scholarly journals Molecular Determinants of Humanether-à-go-go-Related Gene 1 (hERG1) K+Channel Activation by NS1643

2010 ◽  
Vol 79 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Morten Grunnet ◽  
Jennifer Abbruzzese ◽  
Frank B. Sachse ◽  
Michael C. Sanguinetti
Keyword(s):  
K Channel ◽  
Related Gene ◽  
Channel Activation ◽  
Molecular Determinants

Block of the human ether-a-go-go-related gene (hERG) K+ channel by the antidepressant desipramine

2010 ◽  
Vol 394 (3) ◽  
pp. 536-541 ◽  
Author(s):  
Hee-Kyung Hong ◽  
Mi-Hyeong Park ◽  
Byung Hoon Lee ◽  
Su-Hyun Jo
Keyword(s):  
K Channel ◽  
Related Gene

Regulation of the human ether-a-go-go-related gene (hERG) potassium channel by Nedd4 family interacting proteins (Ndfips)

2015 ◽  
Vol 472 (1) ◽  
pp. 71-82 ◽  
Author(s):  
Yudi Kang ◽  
Jun Guo ◽  
Tonghua Yang ◽  
Wentao Li ◽  
Shetuan Zhang
Keyword(s):  
Potassium Channel ◽  
Precursor Cell ◽  
K Channel ◽  
Neural Precursor ◽  
Cardiac Repolarization ◽  
Interacting Proteins ◽  
Neural Precursor Cell ◽  
Related Gene ◽  
Cellular Compartments ◽  
Herg Channels

The human ether-a-go-go-related gene (hERG)-encoded K+ channel is critical for cardiac repolarization. In the present study, we demonstrate that the E3 ubiquitin (Ub) ligase neural precursor cell expressed developmentally down-regulated protein 4-2 (Nedd4-2) is directed to specific cellular compartments by Nedd4 family-interacting proteins (Ndfips) to selectively target the mature hERG channels for degradation.

scholarly journals Structural Basis forEther-a-go-go-Related Gene K+Channel Subtype-Dependent Activation by Niflumic Acid

2008 ◽  
Vol 73 (4) ◽  
pp. 1159-1167 ◽  
Author(s):  
David Fernandez ◽  
John Sargent ◽  
Frank B. Sachse ◽  
Michael C. Sanguinetti
Keyword(s):  
Niflumic Acid ◽  
Structural Basis ◽  
K Channel ◽  
Related Gene
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