Functional Assessment of Adipose Stem Cells for Xenotransplantation Using Myocardial Infarction Immunocompetent Models: Comparison with Bone Marrow Stem Cells

2011 ◽  
Vol 67 (2) ◽  
pp. 263-273 ◽  
Author(s):  
Arghya Paul ◽  
Sapna Srivastava ◽  
Guangyong Chen ◽  
Dominique Shum-Tim ◽  
Satya Prakash
Keyword(s):  
Myocardial Infarction ◽  
Stem Cells ◽  
Bone Marrow ◽  
Functional Assessment ◽  
Bone Marrow Stem Cells ◽  
Adipose Stem Cells ◽  
Models Comparison

scholarly journals Osteoblastogenesis Alters Small RNA Profiles in EVs Derived from Bone Marrow Stem Cells (BMSCs) and Adipose Stem Cells (ASCs)

Biomedicines ◽  
2020 ◽  
Vol 8 (10) ◽  
pp. 387
Author(s):  
Yan Yan ◽  
Clare Chang ◽  
Junyi Su ◽  
Morten T. Venø ◽  
Jørgen Kjems
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Small Rna ◽  
Expression Profiles ◽  
Osteoblastic Differentiation ◽  
Bone Marrow Stem Cells ◽  
Adipose Stem Cells ◽  
Special Focus ◽  
Paracrine Factors ◽  
Specific Subset

Multipotent stem cells (MSCs) are used in various therapeutic applications based on their paracrine secretion activity. Here, we set out to identify and characterize the paracrine factors released during osteoblastogenesis, with a special focus on small non-coding RNAs released in extracellular vesicles (EVs). Bone marrow stem cells (BMSCs) and adipose stem cells (ASCs) from healthy human donors were used as representatives of MSCs. We isolated EVs secreted before and after induction of osteoblastic differentiation and found that the EVs contained a specific subset of microRNAs (miRNAs) and tRNA-derived small RNAs (tsRNA) compared to their parental cells. Osteoblastic differentiation had a larger effect on the small RNA profile of BMSC-EVs relative to ASC-EVs. Our data showed that EVs from different MSC origin exhibited distinct expression profiles of small RNA profiles when undergoing osteoblastogenesis, a factor that should be taken into consideration for stem cell therapy.

scholarly journals Bone Marrow Stem Cells for Myocardial Infarction

2005 ◽  
Vol 96 (1) ◽  
pp. 6-8 ◽  
Author(s):  
Florian P. Limbourg ◽  
Helmut Drexler
Keyword(s):  
Myocardial Infarction ◽  
Stem Cells ◽  
Bone Marrow ◽  
Bone Marrow Stem Cells

scholarly journals Age-Dependent Availability and Functionality of Bone Marrow Stem Cells in an Experimental Model of Acute and Chronic Myocardial Infarction

2011 ◽  
Vol 20 (3) ◽  
pp. 407-419 ◽  
Author(s):  
Ana Ayala-Lugo ◽  
Angela M. V. Tavares ◽  
Ana H. R. Paz ◽  
Ana Alegretti ◽  
Ludmila Miquelito ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cells ◽  
Bone Marrow ◽  
Experimental Model ◽  
Bone Marrow Stem Cells ◽  
Chronic Myocardial Infarction ◽  
Age Dependent
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