scholarly journals Serum Glial Fibrillary Acidic Protein in Acute Stroke

2020 ◽  
Vol 33 (1) ◽  
pp. 35-36
Author(s):  
David B. Seder
Keyword(s):  
Glial Fibrillary Acidic Protein ◽  
Acute Stroke ◽  
Acidic Protein

Glial fibrillary acidic protein in acute stroke: what we know and what we need to know

2018 ◽  
Vol 3 ◽  
pp. 14-14 ◽  
Author(s):  
Michal Rozanski ◽  
Heinrich J. Audebert
Keyword(s):  
Glial Fibrillary Acidic Protein ◽  
Acute Stroke ◽  
Acidic Protein

scholarly journals Diagnostic Accuracy of Plasma Glial Fibrillary Acidic Protein for Differentiating Intracerebral Hemorrhage and Cerebral Ischemia in Patients with Symptoms of Acute Stroke

2012 ◽  
Vol 58 (1) ◽  
pp. 237-245 ◽  
Author(s):  
Christian Foerch ◽  
Marion Niessner ◽  
Tobias Back ◽  
Michael Bauerle ◽  
Gian Marco De Marchis ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Glial Fibrillary Acidic Protein ◽  
Intracerebral Hemorrhage ◽  
Diagnostic Accuracy ◽  
Acute Stroke ◽  
Symptom Onset ◽  
Point Of Care ◽  
Area Under The Curve ◽  
Acidic Protein ◽  
Stroke Mimic

Abstract BACKGROUND Glial fibrillary acidic protein (GFAP) is a biomarker candidate indicative of intracerebral hemorrhage (ICH) in patients with symptoms of acute stroke. GFAP is released rapidly in the presence of expanding intracerebral bleeding, whereas a more gradual release occurs in ischemic stroke. In this study the diagnostic accuracy of plasma GFAP was determined in a prospective multicenter approach. METHODS Within a 1-year recruitment period, patients suspected of having acute (symptom onset <4.5 h before admission) hemispheric stroke were prospectively included into the study in 14 stroke centers in Germany and Switzerland. A blood sample was collected at admission, and plasma GFAP was measured by use of an electrochemiluminometric immunoassay. The final diagnosis, established at hospital discharge, was classified as ICH, ischemic stroke, or stroke mimic. RESULTS The study included 205 patients (39 ICH, 163 ischemic stroke, 3 stroke mimic). GFAP concentrations were increased in patients with ICH compared with patients with ischemic stroke [median (interquartile range) 1.91 μg/L (0.41–17.66) vs 0.08 μg/L (0.02–0.14), P < 0.001]. Diagnostic accuracy of GFAP for differentiating ICH from ischemic stroke and stroke mimic was high [area under the curve 0.915 (95% CI 0.847–0.982), P < 0.001]. A GFAP cutoff of 0.29 μg/L provided diagnostic sensitivity of 84.2% and diagnostic specificity of 96.3% for differentiating ICH from ischemic stroke and stroke mimic. CONCLUSIONS Plasma GFAP analysis performed within 4.5 h of symptom onset can differentiate ICH and ischemic stroke. Studies are needed to evaluate a GFAP point-of-care system that may help optimize the prehospital triage and management of patients with symptoms of acute stroke.

The accuracy of glial fibrillary acidic protein in acute stroke differential diagnosis: A meta-analysis

2013 ◽  
Vol 73 (8) ◽  
pp. 601-606 ◽  
Author(s):  
Yi Sun ◽  
Qin Qin ◽  
Yan-Jun Shang ◽  
Chao-Ping Fang ◽  
Wei-Wei Zhang ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Glial Fibrillary Acidic Protein ◽  
Acute Stroke ◽  
Meta Analysis ◽  
Acidic Protein

scholarly journals THE INFLUENCE OF SAMPLING TIME TO SERUM GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) LEVELS IN ACUTE STROKE

2019 ◽  
Vol 5 (1) ◽  
pp. 30-33
Author(s):  
Neila Raisa ◽  
Hidayat Sujuti ◽  
Hari Purnomo ◽  
Masruroh Rahayu ◽  
Mochamad Dalhar
Keyword(s):  
Glial Fibrillary Acidic Protein ◽  
Acute Stroke ◽  
Sampling Time ◽  
Acidic Protein

Expression of glial fibrillary acidic protein, actin, fibronectin and factor VIII antigen in human astrocytomas

Pathology ◽  
1983 ◽  
Vol 15 (4) ◽  
pp. 373-378 ◽  
Author(s):  
Stephen J. Lolait ◽  
J.H. Harmer ◽  
G. Auteri ◽  
J.S. Pedersen ◽  
B.H. Toh
Keyword(s):  
Glial Fibrillary Acidic Protein ◽  
Factor Viii ◽  
Acidic Protein ◽  
Factor Viii Antigen ◽  
Human Astrocytomas
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